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Immunosuppression and mycobacteria other than Mycobacterium tuberculosis: results from patients with and without HIV infection

Published online by Cambridge University Press:  15 May 2009

M. Peters ,
D. Schürmann ,
A. C. Mayr ,
R. Hetzer ,
H. D. Pohle  and
B. Ruf
M. Peters
Affiliation:
II. Department of Internal Medicine, FRG
D. Schürmann
Affiliation:
II. Department of Internal Medicine, FRG
A. C. Mayr
Affiliation:
Department of Oncology, Rudolf Virchow University Hospital (Wedding), FRG
R. Hetzer
Affiliation:
Freie Universität Berlin; Deutsches Herzzentrum Berlin; FRG
H. D. Pohle
Affiliation:
II. Department of Internal Medicine, FRG
B. Ruf
Affiliation:
II. Department of Internal Medicine, FRG
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Summary

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Infections caused by mycobacteria other than Mycobacterium tuberculosis (MOTT) have often been described as common in AIDS patients. To evaluate whether infections with MOTT are specific for HIV related immunosuppression or are also frequent in patients with immunosuppression of different aetiology, data on the frequency of isolation from immunosuppressed patients with HIV infection are important. Blood, stool and urine specimens from 134 patients with non-HIV related immunosuppression, and from 55 immunocompetent subjects were examined for mycobacteria. MOTT have been isolated from one immunocompetent person but from none of the immunosuppressed patients. Since in AIDS patients an initial colonization of the gastrointestinal tract (GI-tract) with MOTT is common, GI-tract biopsy specimens from an additional 80 patients were examined microscopically and histologically for mycobacteria. Mycobacteria were not isolated from these specimens.

In the same period of time 72 AIDS patients have been examined: 7 (10%) had infections with M. tuberculosis whereas MOTT have been isolated from 16 (22%) of these patients. Mycobacteria have been found only rarely in immunocompetent patients and have not been isolated from patients with non-HIV related immunosuppression. The isolation of MOTT is highly correlated with an HIV-related immunosuppression.

Type
Research Article
Information
Epidemiology & Infection , Volume 103 , Issue 2 , October 1989 , pp. 293 - 300
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

1.Gottlieb, MS, Schrof, R, Schanker, HM et al. , Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med 1981; 305: 1425–31.CrossRefGoogle ScholarPubMed
2.Masur, H, Michelis, MA, Greene, JB. et al. An outbreak of community acquired Pneumocystis carinii pneumonia. N Engl J Med 1981; 305: 1431–8.CrossRefGoogle ScholarPubMed
3.Macher, EC, Kovacs, JA, Gill, V. et al. Bacteremia due to Mycobacterium avium-intracellulare in the acquired immunodeficiency syndrome. Ann Intern Med 1983; 99: 782–5.CrossRefGoogle ScholarPubMed
4.Wolinski, E.Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis 1979; 107: 119–58.Google Scholar
5.Ahn, CH, Lowell, JR, Onstad, GD, Shuford, EH, Hurst, GA.A demographic study of disease due to Mycobacterium kansasii or M. intracellulare-avium in Texas. Chest 1979; 75: 120–5.CrossRefGoogle ScholarPubMed
6.Young, LS.Mycobacterium avium complex infection. J Infect Dis 1988; 157: 863–7.CrossRefGoogle ScholarPubMed
7.Horsburgh, CR, Mason, UG, Farhi, DC, Iseman, MD.Disseminated infections with Mycobacterium avium-intracellulare. Medicine 1985; 64: 36–48.CrossRefGoogle ScholarPubMed
8.Ortbals, DW, Marr, J.A comparative study of tuberculous and other mycobacterial infections and their associations with malignancy. Am Rev Respir Dis 1978; 117: 39–45.Google ScholarPubMed
9.Feld, R, Bodey, GP, Gröschel, D.Mycobacteriosis in patients with malignant disease. Arch Intern Med 1976; 136: 67–70.CrossRefGoogle ScholarPubMed
10.Horsburgh, CR, Cohn, DL, Robert, RB et al. , Mycobacterium avium-M. intracellulare isolates from patients with or without acquired immunodeficiency syndrome. Antimicrob Agents Chemother 1986; 30: 955–7.CrossRefGoogle ScholarPubMed
11.Armstrong, D, Gold, JWM, Dryanski, J. et al. Treatment of infections in patients with the acquired immunodeficiency syndrome. Ann Int Med 1985; 103: 738–43.CrossRefGoogle ScholarPubMed
12.Young, LS, Inderlied, CB, Berlin, OG, Gottlieb, MS.Mycobacterial infections in AIDS patients, with an emphasis on the Mycobacterium avium complex. Rev Infect Dis 1986; 9: 1024–33.CrossRefGoogle Scholar
13.Collins, FM.Mycobacterium avium complex infections and development of the acquired immunodeficiency syndrome: Casual opportunist or causal cofactor ? Int J Lepr 1986; 54: 458–74.Google ScholarPubMed
14.Good, RC.Opportunistic mycobacteria infections. Adv Exp Med Biol 1986; 202: 73–82.CrossRefGoogle Scholar
15.Kiehn, TE, Cammarata, R.Laboratory diagnosis of mycobacterial infections in patients with acquired immunodeficiency syndrome. J Clin Microbiol 1986; 24: 708–11.CrossRefGoogle ScholarPubMed
16.Centers for Disease Control. Revision of the CDC surveillance. Case definition for acquired immunodeficiency syndrome. MMWR 1987; 36: N 1 (Suppl.).Google Scholar
17.Vestal, AL.Procedures for the isolation of mycobacteria. Atlanta, Georgia: Center for Disease Control, Department of Health, Education and Welfare. 1975 DHEW publication no. 75–8230.Google Scholar
18.Schaefer, WB.Serologic identification and classification of the atypical mycobacteria by their agglutination. Am Rev Respir Dis 1965; 92: (Suppl.): 85–93.Google ScholarPubMed
19.Edwards, LB, Palmer, CE.Isolation of atypical mycobacteria from healthy persons. Am Rev Respir Dis 1959; 80: 747–9.CrossRefGoogle ScholarPubMed
20.Radenbach, KL.Diagnostische und therapeutische Fortschritte bei nichttuberkulösen Mykobakteriosen. Prax Klin Pneumol 1985; 39: 43–9.Google Scholar
21.Pitchenik, AE, Russel, BW, Cleary, T, Pejovic, I, Cole, C, Snider, DE.The prevalence of tuberculosis and drug resistance among Haitians. N Engl J Med 1982; 307: 162–5.CrossRefGoogle ScholarPubMed
22.Edwards, LB, Acquaviva, FA, Livesay, VT, Cross, FW, Palmer, CE.An atlas of sensitivity to tuberculin, PPD-B and histoplasmin in the United States. Am Rev Respir Dis 1969; 99: 1–18.Google ScholarPubMed
23.Pitchenik, AE, Cole, C, Russel, BW, Fischl, MA, Spira, TJ, Snider, DE.Tuberculosis, atypical mycobacteriosis, and the acquired immunodeficiency syndrome among Haitian and non- Haitian patients in south Florida. Ann Intern Med 1984; 101: 641–5.CrossRefGoogle ScholarPubMed
24.Pitchenik, AE, Burr, J, Cole, CH.Tuberculin testing for persons with positive serologic studies for HTLV-III. N Engl J Med 1986; 314: 447.Google ScholarPubMed
25.Hawkins, CC, Gold, JWM, Whimbey, E. et al. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1986; 105: 184–8.CrossRefGoogle ScholarPubMed
26.Damsker, B, Buttone, EJ.Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: Concepts regarding acquisition and pathogenesis. J Infect Dis 1985; 151: 179–81.CrossRefGoogle ScholarPubMed
27.Dworkin, B, Wormser, GP, Rosenthal, WS et al. , Gastrointestinal manifestations of the acquired immunodeficiency syndrome. Am J Gastroenterol 1985; 80: 774–8.Google ScholarPubMed
28.Kehrein, B, Ruf, B, Thalmann, U. et al. Mykobakteriosen bei AIDS. Patholge 1988; 9: 218–27.Google ScholarPubMed
29.Kiehn, TE, Edwards, FF, Brannon, P. et al. Infections caused by Mycobacterium avium complex in immunocompromised patients: Diagnosis by blood culture and fecal examination, antimicrobial susceptibility tests, and morphological and seroagglutination characteristics. J Clin Microbiol 1985; 21: 168–73.CrossRefGoogle ScholarPubMed
30.Gangadharam, PRJ, Edwards, CK.Release of superoxide anion from resident and activated mouse peritoneal macrophages infected with Mycobacterium intracellulare.Am Rev Respir Dis 1984; 151: 179–81.Google Scholar
31.Meissner, G, Anz, W.Sources of Mycobacterium avium complex infection resulting in human diseases. Ann Rev Respir Dis 1977; 116: 1057–64.Google ScholarPubMed
32.Fauci, AS.Acquired immunodeficiency syndrome: epidemiologic, immunologic and therapeutic considerations. Ann Intern Med 1984; 110: 92–106.CrossRefGoogle Scholar
33.Murray, JF, Felton, CP, Garay, SM. et al. Pulmonary complications of the acquired immunodeficiency syndrome. N Engl J Med 1984; 310: 1682–8.CrossRefGoogle ScholarPubMed
34.Gill, VJ, Park, CH, Stock, F, Gosey, LL, Witebsky, FG, Masur, H.Use of lysis-centrifugation (Isolator) and Radiometric (BACTEC) blood culture systems for the detection of mycobacteremia. J Clin Microbiol 1985; 22: 543–5.CrossRefGoogle ScholarPubMed
35.Winter, SM, Bernard, EM, Gold, JWM, Armstrong, D.Humoral response to disseminated infections by Mycobacterium avium-Mycobacterium intracellulare in the acquired immunodeficiency syndrome and hairy cell leukemia. J Infect Dis 1985; 151: 523–7.CrossRefGoogle ScholarPubMed
36.Ruf, B, Schürmann, D, Matos-Marques, B. et al. Bedeutung und Diagnostik der Mykobakterien bei Patienten mit HIV-Infektion: Ergebnisse einer prospektiven Studie über zwei Jahre (Abstract). Deutscher ATDS-Kongreβ. Programm und Abstracts 1988.Google Scholar