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Hypersensitivity in cattle after foot -and -mouth disease vaccination: response to hydroxypropylmethylcellulose

Published online by Cambridge University Press:  15 May 2009

L. Black ,
F. J. R. R. Menard ,
G. G. Beadle  and
T. W. F. Pay
L. Black
Affiliation:
The Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Surrey
F. J. R. R. Menard
Affiliation:
The Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Surrey
G. G. Beadle
Affiliation:
The Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Surrey
T. W. F. Pay
Affiliation:
The Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Surrey
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Summary

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Intravenous provocation (IVP) tests demonstrated that hydroxypropylmethylcellulose (MC) was able to elicit anaphylactic signs in cattle vaccinated with foot-and-mouth disease (FMD) vaccine produced at one centre but not with similar vaccine produced at another. The former vaccine also provoked serum reagins which were demonstrated by passive cutaneous anaphylaxis (PCA) tests in goats.

Reaginic sera which reacted specifically with MC were used in PCA tests to screen samples taken serially from the vaccine production lines. The reactions observed suggested that a substance with MC or similar specificity was present in the antifoaming agent routinely added to vaccines.

Type
Research Article
Information
Journal of Hygiene , Volume 75 , Issue 1 , August 1975 , pp. 79 - 86
Copyright
Copyright © Cambridge University Press 1975

References

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