Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T16:45:41.787Z Has data issue: false hasContentIssue false
  • English
  • Français

The experimental reproduction of enterotoxaemia in piglets

Published online by Cambridge University Press:  15 May 2009

H. I. Field  and
R. F. W. Goodwin
H. I. Field
Affiliation:
Veterinary Investigation CentreMinistry of Agriculture, Fisheries and Food, Cambridge
R. F. W. Goodwin
Affiliation:
Department of Veterinary Clinical Studies, University of Cambridge
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Whole cultures of Clostridium welchii, Type C (organisms plus toxin), produced enterotoxaemia and death when fed to new-born piglets.

2. The disease could rarely be produced by suspensions of washed organisms given in the same way but was readily initiated by feeding bacteria-free toxin from Type C cultures.

3. Piglets dying from enterotoxaemia induced by bacteria-free toxin showed all the extensive pathological changes of the natural disease; their intestines contained Type C organisms and far greater quantities of toxin than had been given by mouth.

4. Type C organisms could not be demonstrated in the intestines of piglets from healthy litters of the same age, although such animals were carriers of the Type A strain.

5. The clinical signs, with particular reference to the development of hypo-glycaemia, and the pathology of both natural and experimentally induced cases of enterotoxaemia are described.

6. In the light of these findings the pathogenesis and epidemiology of enterotoxaemia in the piglet are discussed.

We wish to thank Mrs B. L. Wardale and Mr P. J. D. V. Brett for general assistance. This study was aided financially by a general grant to one of us (R.F.W.G.) from the Agricultural Research Council.

Type
Research Article
Information
Journal of Hygiene , Volume 57 , Issue 1 , March 1959 , pp. 81 - 91
Copyright
Copyright © Cambridge University Press 1959

References

REFERENCES

Brooks, M. E., Sterne, M. & Warrack, G. H. (1957). A re-assessment of the criteria used for type differentiation of Clostridium perfringens. J. Path. Bact. 74, 185.CrossRefGoogle Scholar
Bullen, J. J. (1952). Enterotoxaemia of sheep: Clostridium welchii type D in the alimentary tract of normal animals. J. Path. Bact. 64, 201.CrossRefGoogle ScholarPubMed
Bullen, J. J. & Batty, I. (1957). Experimental enterotoxaemia of sheep: the effect on the permeability of the intestine and the stimulation of antitoxin production in immune animals. J. Path. Bact. 73, 511.CrossRefGoogle Scholar
Bullen, J. J. & Scarisbrick, R. (1957). Enterotoxaemia of sheep: experimental reproduction of the disease. J. Path. Bact. 73, 495.CrossRefGoogle Scholar
Bullen, J. J., Scarisbrick, R. & Maddock, A. (1953). Enterotoxaemia of sheep: the fate of washed suspensions of Clostridium welchii type D introduced into the rumen of normal sheep. J. Path. Bact. 65, 209.CrossRefGoogle ScholarPubMed
Field, H. I. & Gibson, E. A. (1955). Studies on piglet mortality 2. Clostridium welchii infection. Vet. Rec. 67, 31.Google Scholar
Goodwin, R. F. W. (1955). Some common factors in the pathology of the new-born pig. Brit. vet. J. 111, 361.CrossRefGoogle Scholar
Goodwin, R. F. W. (1957). The relationship between the concentration of blood sugar and some vital body functions in the new-born pig. J. Physiol. 136, 208.CrossRefGoogle ScholarPubMed
Gordon, W. S., Stewart, J., Holman, H. H & Taylor, A. W. (1940). Blood changes and post-mortem findings following intravenous inoculation of sheep with culture filtrates of Cl. welchii, types A, C and D. J. Path. Bact. 50, 251.CrossRefGoogle Scholar
Griner, L. A. & Bracken, F. K. (1953). Clostridium perfringens (type C) in acute hemorrhagic enteritis of calves. J. Amer. vet. med. Ass. 122, 99.Google ScholarPubMed
Griner, L. A. & Johnson, H. W. (1954). Clostridium perfringens type C in hemorrhagic enterotoxemia of lambs. J. Amer. vet. med. Ass. 125, 125.Google ScholarPubMed
Sampson, J., Hester, H. R. & Graham, R. (1942). Studies on baby-pig mortality. II. Further observations on acute hypoglycemia in newly born pigs (so-called baby-pig disease). J. Amer. vet. med. Ass. 100, 33.Google Scholar
Smith, L. DS. (1955). Introduction to the Pathogenic Anaerobes, p. 79. Chicago: University of Chicago Press.Google Scholar
Somogyi, M. (1945). A new reagent for the determination of sugars. J. biol. Chem. 160, 61.CrossRefGoogle Scholar
Szent-Iványi, T. & Szabó, I. (1955). A malacok fertözö elhalásos bélgyulladása I. A beteg-ség oktana és kortana. Mag. állator. Lapja. 10, 403.Google Scholar
Szent-Iványi, T. & Szabó, S. (1956). Infectious necrotic enteritis of sucking pigs. I. Etiology and pathology. Acta vet. hung. 6, 217.Google Scholar