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The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunization

Published online by Cambridge University Press:  19 October 2009

R. M. Anderson ,
J. A. Crombie  and
B. T. Grenfell
R. M. Anderson
Affiliation:
Parasite Epidemiology Research Group, Department of Pure and Applied Biology, Imperial College, University of London, London SW7 2BB
J. A. Crombie
Affiliation:
Parasite Epidemiology Research Group, Department of Pure and Applied Biology, Imperial College, University of London, London SW7 2BB
B. T. Grenfell
Affiliation:
Parasite Epidemiology Research Group, Department of Pure and Applied Biology, Imperial College, University of London, London SW7 2BB
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Mathematical models and statistical analyses of epidemiological data are employed to assess the potential impact of mass vaccination on the incidences of cases of mumps infection and cases of mumps related complications. The analyses reveal that in the United Kingdom the average age at infection with the mumps virus is currently between 6–7 years and that the inter-epidemic period of the infection is approximately 3 years. The critical level of vaccine uptake to eliminate mumps virus transmission is predicted to be approximately 85% of each cohort of boys and girls by the age of 2 years. Analyses of published data show that the risk of complication arising from mumps infection is markedly age- and sex-related. Model predictions suggest that the incidence of orchitis will be increased, over the level pertaining prior to mass vaccination, by levels of vaccine uptake (by 2 years of age) that are less than 70% of each yearly cohort of boys and girls. Moderate (over 00%) to high (75%) levels of vaccine uptake, however, are predicted to reduce the overall incidence of cases of mumps related complications (especially those with CNS involvement).

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 1 , August 1987 , pp. 65 - 84
Copyright
Copyright © Cambridge University Press 1987

References

REFERENCES

Anderson, R. M. & Grenfell, B. T. (1985). Quantitative investigations of different vaccination policies for the control of congenital rubella syndrome (CRS) in the United Kingdom. Journal of Hygiene 96, 305–333.CrossRefGoogle Scholar
Anderson, R. M., Grenfell, B. T. & May, R. M. (1984). Oscillatory fluctuations in the incidence of infectious diseases and the impact of vaccination: time series analysis. Journal of Hygiene 93, 587–608.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1982a). Directly transmitted infectious diseases: control by vaccination. Science 215, 1053–1060.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1982b). The logic of vaccination. Xew Scientist 96. 410–415.Google Scholar
Anderson, R. M. & May, R. M. (1983). Vaccination against rubella and measles: quantitative investigations of different policies. Journal of Hygiene 90, 259–325.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1985a). Vaccination and herd immunity to infectious diseases. Nature 318, 323–329.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1985 b). Age related changes in the rate of disease transmission: implications for the design of vaccination programmes. Journal of Hygiene 94. 365–435.CrossRefGoogle ScholarPubMed
Beard, E. M., Benson, R. C. Jr, Kelaus, P. P.Elvehack, L. R. & Kurland, L. T. (1977). The incidence and outcome of mumps orchitis in Rochester, Minnisota, 1935–1974. Mayo Clinic Proceedings 52, 3–7.Google Scholar
Benenson, A. S. (ed.) (1975). Control of Communicable Diseases in Man. 12th Edn. Washington D. C.: American Public Health Association.Google Scholar
Centers For Disease Control (1984). Mumps surveillance, January, 1977-December, 1982. Atlanta, USA: U. S. Department of Health and Human Services. Centers for Disease Control.Google Scholar
Donaghy, M. (1984). Epidemiology of mumps in Scotland. Communicable Diseases (Scotland) Unit Weekly Report. 42, xi–xviii.Google Scholar
Galbraith, N. S., Youno, S. E. J., Pusky, J. J., Crombik, D. L. & Sparks, I. P. (1984). Mumps surveillance in England and Wales 1962–1981. Laincet i. 91–94.Google Scholar
Grenfell, B. T. & Anderson, R. M. (1986). The estimation of age related rates of infection from case notifications and serological data. Journal of Hygiene 95, 419–436.CrossRefGoogle Scholar
Ho, M. (1979). Systematic viral infections and viral infection in immunosupressed patients. In Antiviral Agents and Viral Infections of Man (ed. Gallasso, G. J. et al. ) pp. 605–611. New York: Raven Press.Google Scholar
IHE (1985). Surveillance des Oreillons en lielgique. Institut dèHygiene et dèEpideèmiologie. Ministere de la Sante Publique et de la Famille, Belgique.Google Scholar
Kalen, A. E. & McLeod, D. A. (1977). Paramyxoviruses: comparative diagnosis of parainfluenza, mumps, measles, and respiratory syneytial virus infections. In Comparative Diagnosis of Viral Diseases. I. Human and Related Viruses Part A. (ed. Kurstak, E. and Kurstak, C.), pp. 503–607. New York: Academic Press.Google Scholar
Miller, C. L. & Miller, E. (1985). Rubella vaccination in the U.K.: time for complete strategy. Lancet ii, 732.CrossRefGoogle Scholar
Mortimer, P. P. (1978). Mumps prophylaxis in the light of a new test for antibody, British Medical Journal 2, 1523–1524.CrossRefGoogle ScholarPubMed
Nokes, D. I., Anderson, R. M. & Anderson, M. J. (1986). Rubella transmission in South East England: a horizontal seroepidemiological study. Journal of Hygiene 96, 291–304.CrossRefGoogle Scholar
RCGP (1974). A retrospective survey of the complications of mumps. Journal of the Royal College of General Practitioners 24, 552–556.Google Scholar
Sato, H., Alhrecht, P., Reynolds, D. W.Stahno, S. & Dennis, F. A. (1979). Transfer of measles, mumps and rubella antibodies from mother to infant. A merican Journal of Infectious Diseases of Children 113, 1240–1243.Google Scholar
Schenzle, D. (1984). An age structured model of pro and post vaccination measles transmission. I. M. A. Journal of Mathematics Applied in Medicine and Biology 1, 169–192.CrossRefGoogle Scholar
Wagenvoort, J. H. T., Harmsen, M., Boutahar-Troun, B. J. K., Kraaijeveld, C. A. & Winkler, K. C. (1980). Epidemiology of mumps in The Netherlands. Journal of Hygiene 85, 313–326.CrossRefGoogle ScholarPubMed
Walker, O., Carter, H. & Jones, I. G. (1980). Measles, mumps and rubella: the need for a change in immunisation policy, British Medical Journal 229, 1501–1502.Google Scholar