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Enteroaggregative Escherichia coli associated with an outbreak of diarrhoea in a neonatal nursery ward

Published online by Cambridge University Press:  15 May 2009

M. Čobeljić
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia, Yugoslavia
B. Miljković-Selimović
Affiliation:
Public Health Centre, Niš, Serbia, Yugoslavia
D. Paunović-Todosijević
Affiliation:
Public Health Centre, Niš, Serbia, Yugoslavia
Z. Veličković
Affiliation:
Public Health Centre, Niš, Serbia, Yugoslavia
Z. Lepšanović
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia, Yugoslavia
N. Zec
Affiliation:
Institute of Preventive Medicine, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia, Yugoslavia
D. Savić
Affiliation:
University Clinic Centre, Niš, Serbia, Yugoslavia
R. Ilić
Affiliation:
University Clinic Centre, Niš, Serbia, Yugoslavia
S. Konstantinović
Affiliation:
University Clinic Centre, Niš, Serbia, Yugoslavia
B. Jovanović
Affiliation:
University Clinic Centre, Niš, Serbia, Yugoslavia
V. Kostić
Affiliation:
University Clinic Centre, Niš, Serbia, Yugoslavia
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Summary

Over a 9-day period in February 1995, 16 newborn babies (age range 2–11 days) and 3 infants (24, 47 and 180 days of age) in a neonatal nursery ward developed diarrhoea accompanied by pyrexia and weight loss. Known enteropathogens were not detected in their stools but Escherichia coli displaying aggregative adherence to HEp-2 cells (enteroaggregative E. coli) were found in 12 (63%) ill infants and in none of 5 well neonates (P = 0·02). The illness lasted 3–9 days (mean 5·2) in 16 babies, whereas in 3 neonates it showed a protracted course of 18–20 days. The source of infection and the mode of transmission remained unclear. The outbreak isolates manifested properties common in this new group of diarrhoeagenic E. coli: mannose-resistant haemagglutination, haemolysis on blood agar, and clump formation in liquid culture medium. They belonged to the O4 E. coli serogroup and expressed multiple antibiotic resistance.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1996

References

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