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Antigenic and genetic analyses of influenza type B viruses isolated in Russia, 1987–91

Published online by Cambridge University Press:  15 May 2009

M. L. Hemphill ,
P. A. Rota ,
V. T. Ivanova ,
A. N. Slepushkin  and
A. P. Kendal
M. L. Hemphill
Affiliation:
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
P. A. Rota
Affiliation:
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
V. T. Ivanova
Affiliation:
The D. I. Ivanovsky Institute of Virology, Gamaleya Street 16, Moscow, 123098 Russia
A. N. Slepushkin
Affiliation:
The D. I. Ivanovsky Institute of Virology, Gamaleya Street 16, Moscow, 123098 Russia
A. P. Kendal
Affiliation:
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
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Four influenza type B viruses isolated in Russia during periods of relatively low (1987–8) or high (1990–1) influenza B activity were characterized antigenically using a microneutralization assay. These isolates were antigenically similar to contemporary reference strains from either of two separate lineages represented by B/Victoria/2/87 and B/Yamagata/16/88. The evolutionary relationships of the variable portion of the haemagglutinin (HA1) genes of these viruses were determined by comparison with influenza B HA1 sequences previously obtained. The Isolate B/USSR/2/87, collected during the 1987–8 influenza season, was found to be closely related to viruses on the B/Victoria/2/87 lineage that circulated during the 1988–9 influenza season in the United States. Sequence analysis of the isolates from the 1990–1 influenza season demonstrated co-circulation of viruses from both the B/Victoria/2/87 and B/Yamagata/16/88 lineages in Russia, confirming the antigenic analysis.

Type
Research Article
Information
Epidemiology & Infection , Volume 111 , Issue 3 , December 1993 , pp. 539 - 546
Copyright
Copyright © Cambridge University Press 1993

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