The Punta Peligro fauna includes some of the oldest Cenozoic South American mammals, and the oldest ones for Patagonia. In addition to frogs, turtles, and crocodiles, an unusual mammalian assemblage is formed by a mixture of Mesozoic lineages of Gondwanan origin and therians (eutherians and metatherians) derived from Laurasian immigrants. This paper describes new remains of the Didolodontidae ‘condylarth’ genus Escribania Bonaparte, Van Valen & Kramarz, 1993. The new material includes an isolated right lower third molar with talonid morphology different from the homologous structure of the type species Escribania chubutensis Bonaparte, Van Valen & Kramarz, 1993, justifying the recognition of a new species. The derived nature of the didolodontid ‘condylarths’ from the Banco Negro Inferior, their differences with the Mioclaenidae Kollpaniinae from the early Paleocene of Tiupampa, and the record of bona fide litoptherns in the Banco Negro Inferior (BNI) suggest an early radiation of the panameriungulates.