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Serum NGF levels in children and adolescents with either Williams syndrome or Down syndrome

Published online by Cambridge University Press:  16 November 2000

Gemma Calamandrei
Affiliation:
Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Rome, Italy.
Enrico Alleva
Affiliation:
Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Rome, Italy.
Francesca Cirulli
Affiliation:
Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Rome, Italy.
Armelle Queyras
Affiliation:
Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Rome, Italy.
Virginia Volterra
Affiliation:
Institute of Psychology, Consiglio Nazionale delle Ricerche, Rome, Italy.
Olga Capirci
Affiliation:
Institute of Psychology, Consiglio Nazionale delle Ricerche, Rome, Italy.
Stefano Vicari
Affiliation:
IRCCS Children's Hospital Bambino Gesù, Santa Marinella , Italy.
Aldo Giannotti
Affiliation:
IRCCS Children's Hospital Bambino Gesù, Rome, Italy.
Paolo Turrini
Affiliation:
Institute of Neurobiology, Consiglio Nazionale delle Ricerche, Viale C. Marx 15, I-00137 Rome, Italy.
Luigi Aloe
Affiliation:
Institute of Neurobiology, Consiglio Nazionale delle Ricerche, Viale C. Marx 15, I-00137 Rome, Italy.
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Abstract

The neurotrophin nerve growth factor (NGF) is a major regulator of peripheral and central nervous system development. Serum NGF was measured in normally developing control children (n=26) and in individuals affected by congenital syndromes associated with learning disability: either Williams syndrome (WS; n=12) or Down syndrome (DS; n=21). Participants were assessed at three distinct developmental stages: early childhood (2 to 6 years), childhood (8 to 12 years), and adolescence (14 to 20 years). A sample was taken only once from each individual. Serum NGF levels were markedly higher in participants with WS, than DS and control participants. In addition, different developmental profiles emerged in the three groups: while in normally developing individuals NGF levels were higher in early childhood than later on, children with WS showed constantly elevated NGF levels. When compared to control participants, those with DS showed lower NGF levels only during early childhood. Neuropsychological assessment confirmed previously reported differences among the three groups in the development of linguistic/cognitive abilities. Some features of individuals with WS, such as hyperacusis and hypertension, could be related to high-circulating NGF levels.

Type
Original Articles
Copyright
2000 Mac Keith Press

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