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Familial dyslexia: neurocognitive and genetic correlation in a large Finnish family

Published online by Cambridge University Press:  16 September 2002

Jaana Nopola-Hemmi
Affiliation:
Department of Paediatric Neurology, Hospital for Children and Adolescents, University of Helsinki, Finland.
Birgitta Myllyluoma
Affiliation:
Department of Paediatric Neurology, Hospital for Children and Adolescents, University of Helsinki, Finland.
Arja Voutilainen
Affiliation:
Department of Paediatric Neurology, Hospital for Children and Adolescents, University of Helsinki, Finland.
Seija Leinonen
Affiliation:
Niilo Mäki Institute, University of Jyväskylä, Jyväskylä, Finland.
Juha Kere
Affiliation:
Department of Medical Genetics, Biomedicum, University of Helsinki, Finland.
Timo Ahonen
Affiliation:
Niilo Mäki Institute, University of Jyväskylä, Jyväskylä, Finland.
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Abstract

Neuropsychological findings of individuals with dyslexia (n=24) from a large, three-generation Finnish family are presented. We have previously performed whole genome linkage scanning in this family and found that dyslexia in this kindred segregates with a single locus in the pericentromeric area of chromosome 3. Those included in the analyses were carefully evaluated for general cognitive ability, reading and spelling skills, and reading-related neurocognitive skills. The neurocognitive type of dyslexia segregating in this family consisted of deficits in phonological awareness, verbal short-term memory, and rapid naming. Severe dyslexia also seemed to be connected with a general language difficulty and was most common in the eldest generation.

Type
Original Articles
Copyright
© 2002 Mac Keith Press

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