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Vulnerability to depression: A moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds

Published online by Cambridge University Press:  23 July 2013

Adrienne M. Banny ,
Dante Cicchetti ,
Fred A. Rogosch ,
Assaf Oshri  and
Nicki R. Crick
Adrienne M. Banny*
Affiliation:
University of Minnesota
Dante Cicchetti*
Affiliation:
University of Minnesota University of Rochester
Fred A. Rogosch
Affiliation:
University of Rochester
Assaf Oshri
Affiliation:
University of Rochester
Nicki R. Crick
Affiliation:
University of Minnesota
*
Address correspondence and reprint requests to: Adrienne M. Banny or Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455; E-mail: banny001@umn.edu or cicchett@umn.edu.
Address correspondence and reprint requests to: Adrienne M. Banny or Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455; E-mail: banny001@umn.edu or cicchett@umn.edu.
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Abstract

Child maltreatment, peer victimization, and a polymorphism of the serotonin transporter gene (5-HTTLPR) were examined as predictors of depressive symptomatology. Children (M age = 11.26, SD = 1.65), including 156 maltreated and 145 nonmaltreated children from comparable low socioeconomic backgrounds, provided DNA samples and self-reports of relational peer victimization, overt peer victimization, and depressive symptoms. Path analysis showed that relational and overt victimization mediated the association between child maltreatment and depressive symptoms. Bootstrapping procedures were used to test moderated mediation and demonstrated that genotype moderated the indirect effects of relational and overt victimization on child depressive symptoms, such that victimized children with the long/long variation were at an increased risk for depressive symptoms compared to victimized children carrying a short allele. Results highlight the utility of examining process models that incorporate biological and psychological factors contributing to the development of depressive symptomatology and provide direction toward understanding and promoting resilience among high-risk youth from a multiple levels of analysis approach.

Type
Regular Articles
Information
Development and Psychopathology , Volume 25 , Issue 3 , August 2013 , pp. 599 - 614
Copyright
Copyright © Cambridge University Press 2013 

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References

Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H., et al. (2009). Early adversity and 5-HTT/BDNF genes: New evidence of gene–environment interactions on depressive symptoms in a general population. Psychological Medicine, 39, 1425–1432.CrossRefGoogle ScholarPubMed
Åslund, C., Leppert, J., Comasco, E., Nordquist, N., Oreland, L., & Nilsson, K. W. (2009). Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression: A population-based study. Behavior Genetics, 39, 524–531.CrossRefGoogle ScholarPubMed
Barnett, D., Manly, J. T., & Cicchetti, D. (1993). Defining child maltreatment: The interface between policy and research. In Cicchetti, D. & Toth, S. L. (Eds.), Child abuse, child development, and social policy (pp. 7–74). Norwood, NJ: Ablex.Google Scholar
Baron, R. M., & Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality & Social Psychology, 51, 1173–1182.CrossRefGoogle ScholarPubMed
Benjet, C., Thompson, R. J., & Gotlib, I. H. (2010). 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls. Journal of Child Psychology and Psychiatry, 51, 173–179.CrossRefGoogle ScholarPubMed
Boivin, M., Hymel, S., & Bukowski, W. M. (1995). The roles of social withdrawal, peer rejection, and victimization by peers in predicting loneliness and depressed mood in children. Development and Psychopathology, 7, 765–786.CrossRefGoogle Scholar
Bolger, K. E., & Patterson, C. J. (2001). Developmental pathways from child maltreatment to peer rejection. Child Development, 72, 549–568.CrossRefGoogle ScholarPubMed
Bolger, K. E., Patterson, C. J., & Kupersmidt, J. B. (1998). Peer relationships and self-esteem among children who have been maltreated. Child Development, 69, 1171–1197.Google ScholarPubMed
Browne, A., & Finkelhor, D. (1986). Impact of child sexual abuse: A review of the research. Psychological Bulletin, 99, 66–77.CrossRefGoogle ScholarPubMed
Brummet, B. H., Boyle, S. H., Siegler, I. C., Kuhn, C. M., Ashley-Koch, A., Jonassaint, C. R., et al. (2008). Effects of environmental stress and gender on associations among symptoms of depression and serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavioral Genetics, 38, 34–43.CrossRefGoogle Scholar
Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., et al. (2009). Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience, 164, 108–120.CrossRefGoogle Scholar
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509–527.CrossRefGoogle Scholar
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H. L., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.CrossRefGoogle ScholarPubMed
Charney, D. S. (2004). Psychobiological mechanisms of resilience and vulnerability: Implications for successful adaptation to extreme stress. American Journal of Psychiatry, 161, 195–216.CrossRefGoogle ScholarPubMed
Chipman, P., Jorm, A. F., Prior, M., Sanson, A., Smart, D., Tan, X., et al. (2007). No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys. American Journal of Medical Genetics, 144B, 561–565.Google ScholarPubMed
Chorbov, V. M., Lobos, E. A., Todorov, A. A., Heath, A. C., Botteron, K. N., & Todd, R. D. (2007). Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. American Journal of Medical Genetics, 144B, 830–833.Google Scholar
Cicchetti, D. (1993). Developmental psychopathology: Reactions, reflections, projections. Developmental Review, 13, 471–502.CrossRefGoogle Scholar
Cicchetti, D. (2010). Resilience under conditions of extreme stress: A multilevel perspective. World Psychiatry, 9, 145–154.CrossRefGoogle Scholar
Cicchetti, D., & Curtis, W. J. (Eds.). (2007). A multilevel approach to resilience [Special Issue]. Development and Psychopathology, 19, 627–955.CrossRefGoogle Scholar
Cicchetti, D., & Lynch, M. (1995). Failures in the expectable environment and their impact on individual development: The case of child maltreatment. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology: Vol. 2. Risk, disorder and adaptation (pp. 32–71). New York: Wiley.Google Scholar
Cicchetti, D., Lynch, M., Shonk, S., & Manly, J. T. (1992). An organizational perspective on peer relations in maltreated children. In Parke, R. D. & Ladd, G.W. (Eds.), Family–peer relationships: Modes of linkage (pp. 345–383). Hillsdale, NJ: Erlbaum.Google Scholar
Cicchetti, D., & Manly, J. T. (1990). A personal perspective on conducting research with maltreatment families: Problems and solutions. In Brody, E. & Sigel, I. (Eds.), Family research: Vol. 2. Families at risk (pp. 87–133). Hillsdale, NJ: Erlbaum.Google Scholar
Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597–600.CrossRefGoogle Scholar
Cicchetti, D., & Rogosch, F. A. (2001). The impact of child maltreatment and psychopathology upon neuroendocrine functioning. Development and Psychopathology, 13, 783–804.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., & Oshri, A. (2011). Interactive effects of corticotrophin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Development and Psychopathology, 23, 1125–1138.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. (2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds. Development and Psychopathology, 19, 1161–1180.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., Sturge-Apple, M., & Toth, S. L. (2010). Interaction of child maltreatment and 5-HTT polymorphisms: Suicidal ideation among children from low-SES backgrounds. Journal of Pediatric Psychology, 35, 536–546.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2006). Fostering secure attachment in infants in maltreating families through preventive interventions. Development and Psychopathology, 18, 623–649.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Schneider-Rosen, K. (1986). An organizational approach to childhood depression. In Rutter, M., Izard, C. E., & Read, P. B. (Eds.), Depression in young people: Developmental and clinical perspectives (pp. 71–134). New York: Guilford Press.Google Scholar
Cicchetti, D., & Toth, S. L. (1995). Developmental psychopathology and disorders of affect. In Cicchetti, D. & Cohen, D. (Eds.), Developmental psychopathology: Vol. 2. Risk, disorder, and adaptation (pp. 369–420). Rochester, NY: University of Rochester Press.Google Scholar
Cicchetti, D., & Toth, S. L. (1998). Perspectives on research and practice in developmental psychopathology. In Damon, W. (Series Ed.) & Sigel, I. & Renninger, K. A. (Vol. Eds.), Handbook of child psychology: Vol. 4. Child psychology in practice (5th ed., pp. 479–583). New York: Wiley.Google Scholar
Cicchetti, D., & Toth, S. L. (2005). Child maltreatment. Annual Review of Clinical Psychology, 1, 409–438.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Toth, S. L. (2010). Child maltreatment: The research imperative and the exportation of results to clinical contexts. In Lester, B. M. & Sparrow, J. D. (Eds.), Nurturing children and families: Building on the legacy of T. Berry Brazelton (pp. 264–274). Oxford: Wiley–Blackwell.CrossRefGoogle Scholar
Cicchetti, D., Toth, S. L., & Manly, J. T. (2003). Maternal Maltreatment Interview. Unpublished manuscript, Rochester, NY.Google Scholar
Cicchetti, D., & Valentino, K. (2006). An ecological transactional perspective on child maltreatment: Failure of the average expectable environment and its influence upon child development. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology (Vol. 3, 2nd ed., pp. 129–201). Hoboken, NJ: Wiley.Google Scholar
Coventry, W. L., James, M. R., Eaves, L. J., Gordon, S. D., Gillespie, N. A., Ryan, L., et al. (2010). Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample. American Journal of Medical Genetics, 153B, 757–765.Google ScholarPubMed
Crick, N. R., & Bigbee, M. A. (1998). Relational and overt forms of peer victimization: A multi-informant approach. Journal of Consulting and Clinical Psychology, 66, 337–347.CrossRefGoogle Scholar
Crick, N. R., Casas, J. F., & Nelson, D. A. (2002). Toward a more comprehensive understanding of peer maltreatment: Studies of relational victimization. Current Directions in Psychological Science, 11, 98–101.CrossRefGoogle Scholar
Crick, N. R., & Grotpeter, J. K. (1996). Children's treatment by peers: Victims of relational and overt aggression. Development and Psychopathology, 8, 367–380.CrossRefGoogle Scholar
Crick, N. R., Nelson, D. A., Morales, J. R., Cullerton-Sen, C., Casas, J. F., & Hickman, S. (2001). Relational victimization in childhood and adolescence: I hurt you through the grapevine. In Juvonen, J. & Graham, S. (Eds.), School-based peer harassment: The plight of the vulnerable and victimized (pp. 196–214). New York: Guilford Press.Google Scholar
Cullerton-Sen, C., Cassidy, A. R., Murray-Close, D., Cicchetti, D., Crick, N. R., & Rogosch, F. A. (2008). Childhood maltreatment and the development of relational and physical aggression: The importance of a gender-informed approach. Child Development, 79, 1736–1751.CrossRefGoogle ScholarPubMed
Cullerton-Sen, C., & Crick, N. R. (2005). Understanding the effects of physical and relational victimization: The utility of multiple perspectives in predicting social–emotional adjustment. School Psychology Review, 34, 147–160.CrossRefGoogle Scholar
Curtis, W. J., & Cicchetti, D. (2003). Moving research on resilience into the 21st century: Theoretical and methodological considerations in examining the biological contributors to resilience. Development and Psychopathology, 15, 773–810.CrossRefGoogle ScholarPubMed
Dean, A. L., Malik, M. M., Richards, W., & Stringer, S. A. (1986). Effects of parental maltreatment on children's conceptions of interpersonal relationships. Developmental Psychology, 22, 617–626.CrossRefGoogle Scholar
Dodge, K. A., Pettit, G. S., & Bates, J. E. (1994). Effects of physical maltreatment on the development of peer relations. Development and Psychopathology, 6, 43–55.CrossRefGoogle Scholar
Duggal, S., Carlson, E. A., Sroufe, L. A., & Egeland, B. (2001). Depressive symptomatology in childhood and adolescence. Development and Psychopathology, 13, 143–164.CrossRefGoogle ScholarPubMed
Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 1041–1049.CrossRefGoogle ScholarPubMed
Dutton, D. G., Van Ginkel, C., & Starzomski, A. (1995). The role of shame and guilt in the intergenerational transmission of abusiveness. Violence & Victims, 10, 121–131.CrossRefGoogle ScholarPubMed
Egeland, B., Jacobvitz, D., & Papatola, K. (1987). Intergenerational continuity of abuse. In Gelles, R. J. & Lancaster, J. B. (Eds.), Child abuse and neglect: Biosocial dimensions (pp. 255–276). New York: Aldine.Google Scholar
Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., et al. (2004). Gene–environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908–915.CrossRefGoogle ScholarPubMed
English, D. J., Upadhyaya, M. P., Litrownik, A. J., Marshall, J. M., Runyan, D. K., Graham, J. C., et al. (2005). Maltreatment's wake: The relationship of maltreatment dimensions to child outcomes. Child Abuse and Neglect, 29, 597–619.CrossRefGoogle ScholarPubMed
Gelernter, J., Kranzler, H., & Cubells, J. F. (1997). Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Human Genetics, 101, 243–246.CrossRefGoogle ScholarPubMed
Greenberg, B. D., Tolliver, T. J., Huang, S., Li, Q., Bengal, D., & Murphy, D. L. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American Journal of Medical Genetics, 88, 83–87.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152.CrossRefGoogle ScholarPubMed
Harrington, R., Rutter, M., Weissman, M., Fudge, H., Groothues, C., Brekenkamp, D., et al. (1997). Psychiatric disorders in the relatives of depressed probands. I: Comparison of prepubertal, adolescent and early adult onset cases. Journal of Affective Disorders, 42, 9–22.CrossRefGoogle ScholarPubMed
Hartup, W. W. (1996). The company they keep: Friendships and their developmental significance. Child Development, 67, 1–13.CrossRefGoogle ScholarPubMed
Haskett, M. E., & Kistner, J. A. (1991). Social interactions and peer perceptions of young physically abused children. Child Development, 62, 979–990.CrossRefGoogle ScholarPubMed
Hodges, E. V. E., Boivin, M., Vitaro, F., & Bukowski, W. M. (1999). The power of friendship: Protection against an escalating cycle of peer victimization. Developmental Psychology, 35, 94–101.CrossRefGoogle ScholarPubMed
Howe, G. W., Beach, S. R. H., & Brody, G. H. (2010). Microtrial methods for translating gene–environment dynamics into preventive interventions. Prevention Science, 11, 343–354.CrossRefGoogle ScholarPubMed
Jacobs, N., Kenis, G., Peeters, F., Derom, C., Vlietinck, R., & van Os, J. (2006). Stress-related negative affectivity and genetically altered serotonin transporter function. Archives of General Psychiatry, 63, 989–996.CrossRefGoogle ScholarPubMed
Jaffee, S. R., Moffitt, T. E., Caspi, A., Fombonne, E., Poulton, R., & Martin, J. (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry, 59, 215–222.CrossRefGoogle ScholarPubMed
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archive of General Psychiatry. Advance online publication.CrossRefGoogle ScholarPubMed
Kaufman, J. (1991). Depressive disorders in maltreated children. American Academy of Child & Adolescent Psychiatry, 30, 257–265.CrossRefGoogle ScholarPubMed
Kaufman, J., Martin, A., King, R. A., & Charney, D. (2001). Are child-, adolescent-, and adult-onset depression one and the same disorder? Biological Psychiatry, 49, 980–1001.CrossRefGoogle ScholarPubMed
Kaufman, J., Yang, B., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor—5-HTTLPR gene interactions and environmental modifiers of depression. Biological Psychiatry, 59, 673–680.CrossRefGoogle ScholarPubMed
Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., et al. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences, 101, 17316–17321.CrossRefGoogle ScholarPubMed
Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Archives of General Psychiatry, 62, 529–535.CrossRefGoogle Scholar
Kim, J., & Cicchetti, D. (2006). Longitudinal trajectories of self-system processes and depressive symptoms among maltreated and nonmaltreated children. Child Development, 77, 624–639.CrossRefGoogle ScholarPubMed
Kim-Cohen, J., & Gold, A. L. (2009). Measuring gene–environment interactions and mechanisms promoting resilient development. Current Directions in Psychological Science, 18, 138–142.CrossRefGoogle Scholar
Koenen, K. C., Moffitt, T. E., Poulton, R., Martin, J., & Caspi, A. (2007). Early childhood factors associated with the development of post-traumatic stress disorder: Results from a longitudinal birth cohort. Psychological Medicine, 37, 181–192.CrossRefGoogle ScholarPubMed
Kovacs, M. (1992). Children's Depression Inventory Manual. North Tonawanda, NY: Multi-Health Systems.Google Scholar
Kovacs, M. (2004). Children's Depression Inventory. Toronto: Multi-Health Systems.Google Scholar
La Greca, A. M., & Harrison, H. M. (2005). Adolescent peer relations, friendships, and romantic relationships: Do they predict social anxiety and depression? Journal of Clinical Child and Adolescent Psychology, 34, 49–61.CrossRefGoogle ScholarPubMed
Lasky-Su, J. A., Faraone, S. V., Glatt, S. J., & Tsuang, M. T. (2005). Meta-analysis of the association between two polymorphisms in serotonin transporter gene and affective disorders. American Journal of Medical Genetics, 133B, 110–115.Google ScholarPubMed
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmid, B., Becker, K., et al. (2009). Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: Evidence from a high-risk community sample of young adults. International Journal of Neuropsychopharmacology, 12, 737–747.CrossRefGoogle ScholarPubMed
Lenroot, R. K., & Giedd, J. N. (2011). Annual research review: Developmental considerations of gene by environment interactions. Journal of Child Psychology and Psychiatry, 52, 429–441.CrossRefGoogle ScholarPubMed
Lesch, K. P. (2003). Neuroticism and serotonin: A developmental genetic perspective. In Plomin, R., DeFries, J., Craig, I., & McGuffin, P. (Eds.), Behavioral genetics in the postgenomic area (pp. 389–423). Washington, DC: American Psychiatric Press.CrossRefGoogle Scholar
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.CrossRefGoogle ScholarPubMed
Lesch, K. P., & Heils, A. (2000). Serotonergic gene transcriptional control regions: Targets for antidepressant drug development? International Journal of Neuropscyhopharmacology, 3, 67–79.Google ScholarPubMed
Loeber, R., Green, S. M., & Lahey, B. B. (1990). Mental health professionals’ perception of the utility of children, mothers, and teachers as informants on childhood psychopathology. Journal of Clinical Child Psychology, 19, 136–143.CrossRefGoogle Scholar
Macmillan, H. L., Fleming, J. E., Streiner, D. L., Lin, E., Boyle, M. H., Jamieson, E., et al. (2001). Childhood abuse and lifetime psychopathology in a community sample. American Journal of Psychiatry, 158, 1878–1883.CrossRefGoogle Scholar
Main, M., Kaplan, N., & Cassidy, J. (1985). Security in infancy, childhood, and adulthood: A move to the level of representation. Monographs of the Society for Research in Child Development, 50, 66–104.CrossRefGoogle Scholar
Manly, J. T. (2005). Advances in research definitions of child maltreatment. Child Abuse and Neglect, 29, 425–439.CrossRefGoogle Scholar
Manly, J. T., Cicchetti, D., & Barnett, D. (1994). The impact of subtype, frequency, chronicity, and severity of child maltreatment on social competence and behavior problems. Development and Psychopathology, 6, 121–143.CrossRefGoogle Scholar
Manly, J. T., Kim, J. E., Rogosch, F. A., & Cicchetti, D. (2001). Dimensions of child maltreatment and children's adjustment: Contributions of developmental timing and subtype. Development and Psychopathology, 13, 759–782.CrossRefGoogle ScholarPubMed
Michaelovsky, E., Frisch, A., Rockah, R., Peleg, L., Magal, N., Shohat, M., et al. (1999). A novel allele in the promoter region of the human serotonin transporter gene. Molecular Psychiatry, 4, 97–99.CrossRefGoogle ScholarPubMed
Mueller, E., & Silverman, N. (1989). Peer relations in maltreated children. In Cicchetti, D. & Carlson, V. (Eds.), Child maltreatment: Theory and research on the causes and consequences of child abuse and neglect (pp. 529–578). Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Munafo, M. R., Durrant, C., Lewis, G., & Flint, J. (2009). Gene × Environment interactions at the serotonin transporter locus. Biological Psychiatry, 65, 211–219.CrossRefGoogle ScholarPubMed
Murray-Close, D., Han, G., Cicchetti, D., Crick, N. R., & Rogosch, F. A. (2008). Neuroendocrine regulation and physical and relational aggression: The moderating roles of child maltreatment and gender. Developmental Psychology, 44, 1160–1176.CrossRefGoogle ScholarPubMed
Muthén, L. K., & Muthén, B. O. (1998). Mplus user's guide. Los Angeles: Author.Google Scholar
Olweus, D. (1993). Victimization by peers: Antecedents and long-term outcomes. In Rubin, K. H. & Asendorph, J. B. (Eds.), Social withdrawal, inhibition, and shyness in childhood. Hillsdale, NJ: Erlbaum.Google Scholar
Paquette, J. A., & Underwood, M. K. (1999). Gender differences in young adolescents' experiences of peer victimization: Social and physical aggression. Merrill–Palmer Quarterly, 45, 242–266.Google Scholar
Pollak, S. D., Cicchetti, D., Hornung, K., & Reed, A. (2000). Recognizing emotion in faces: Developmental effects of child abuse and neglect. Developmental Psychology, 36, 679–688.CrossRefGoogle ScholarPubMed
Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavioral Research Methods, 40, 879–891.CrossRefGoogle ScholarPubMed
Preacher, K. J., & Kelley, K. (2011). Effect size measures for mediation models: Quantitative strategies for communicating indirect effects. Psychological Methods, 16, 93–115.CrossRefGoogle ScholarPubMed
Preacher, K. J., Rucker, D. D., & Hayes, A. F. (2007). Addressing moderated mediation hypotheses: Theory, methods, and prescriptions. Multivariate Behavioral Research, 42, 185–227.CrossRefGoogle ScholarPubMed
Prinstein, M. J., Boergers, J., & Vernberg, E. M. (2001). Overt and relational aggression in adolescents: Social-psychological functioning of aggressors and victims. Journal of Clinical Child Psychology, 30, 477–489.Google Scholar
Putallaz, M., Grimes, C. L., Foster, K. J., Kupersmidt, J. B., Coie, J. D., & Dearing, K. (2007). Physical and relational aggression and victimization: Multiple perspectives within the school setting. Journal of School Psychology, 45, 523–547.CrossRefGoogle Scholar
Rende, R., & Waldman, I. (2006). Behavioral and molecular genetics and developmental psychopathology. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology: Vol. 2. Developmental neuroscience (2nd ed., pp. 427–464). New York: Wiley.Google Scholar
Rieder, C., & Cicchetti, D. (1989). Organizational perspective on cognitive control functioning and cognitive–affective balance in maltreated children. Developmental Psychology, 25, 382–393.CrossRefGoogle Scholar
Risch, N., Herrell, R., Lehner, T., Liang, K., Eaves, L., Hob, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462–2471.CrossRefGoogle ScholarPubMed
Ritchie, K., Jaussent, I., Stewart, R., Dupuy, A., Courtet, P., Ancelin, M., et al. (2009). Association of adverse childhood environment and 5-HTTLPR genotype with late-life depression. Journal of Clinical Psychiatry, 70, 1281–1288.CrossRefGoogle ScholarPubMed
Rogosch, F. A., & Cicchetti, D. (1994). Illustrating the interface of family and peer relations through the study of child maltreatment. Social Development, 3, 291–308.CrossRefGoogle Scholar
Rosen, L. H., Underwood, M. K., Beron, K. J., Gentsch, J. K., Wharton, M. E., & Rahdar, A. (2009). Persistent versus periodic experiences of social victimization: Predictors of adjustment. Journal of Abnormal Child Psychology, 37, 693–704.CrossRefGoogle ScholarPubMed
Rutter, M. (2006). Genes and behavior. London: Blackwell.Google Scholar
Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene–environment interplay and psychology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226–261.CrossRefGoogle ScholarPubMed
Rutter, M., Thapar, A., & Pickles, A. (2009). Gene–environment interactions: Biologically valid pathway or artifact? Archives of General Psychiatry, 66, 1287–1289.CrossRefGoogle ScholarPubMed
Salzinger, S., Feldman, R. S., Hammer, M., & Rosario, M. (1993). The effects of physical abuse on children's social relationships. Child Development, 64, 169–187.CrossRefGoogle ScholarPubMed
Scarr, S., & McCartney, K. (1983). How people make their own environments: A theory of genotype → environment effects. Child Development, 54, 424–435.Google Scholar
Schafer, J. L., & Graham, J. W. (2002). Missing data: Our view of the state of the art. Psychological Methods, 7, 147–177.CrossRefGoogle ScholarPubMed
Schäfer, M., Werner, N. E., & Crick, N. R. (2002). A comparison of two approaches to the study of negative peer treatment: General victimization and bully/victim problems among German schoolchildren. British Journal of Developmental Psychology, 20, 281–306.CrossRefGoogle Scholar
Schwartz, D., Dodge, K. A., Pettit, G. S., & Bates, J. E. (1997). The early socialization of aggressive victims of bullying. Developmental Psychology, 68, 665–675.Google ScholarPubMed
Scott, K. M., Smith, D. R., & Ellis, P. M. (2010). Prospectively ascertained child maltreatment and its association with DSM-IV mental disorders in young adults. Archives of General Psychiatry, 67, 712–719.CrossRefGoogle ScholarPubMed
Sedlak, A., Mettenburg, J., Basena, M., Petta, I., McPherson, K., Greene, A., et al. (2010). Fourth National Incidence Study of Child Abuse and Neglect (NIS-4): Report to Congress. Washington, DC: US Department of Health and Human Services.Google Scholar
Shields, A., & Cicchetti, D. (1998). Reactive aggression among maltreated children: The contributions of attention and emotion dysregulation. Journal of Clinical Child Psychology, 27, 381–395.CrossRefGoogle ScholarPubMed
Shields, A., & Cicchetti, D. (2001). Parental maltreatment and emotion dysregulation as risk factors for bullying and victimization in middle childhood. Journal of Clinical Child Psychology, 30, 349–363.CrossRefGoogle ScholarPubMed
Shields, A., Ryan, R. M., & Cicchetti, D. (2001). Narrative representations of caregivers and emotion dysregulation as predictors of maltreated children's rejection by peers. Developmental Psychology, 37, 321–337.CrossRefGoogle ScholarPubMed
Shrout, P. E., & Bolger, N. (2002). Mediation in experimental and nonexperimental studies: New procedures and recommendations. Psychological Methods, 7, 422–445.CrossRefGoogle ScholarPubMed
Sjoberg, R. L., Nilsson, K. W., Nordquist, N., Ohrvik, J., Leppert, J., Lindstrom, L., et al. (2006). Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. International Journal of Neuropsychopharmacology, 9, 443–449.CrossRefGoogle Scholar
Sobel, M. E. (1982). Asymptotic confidence intervals for indirect effects in structural equation models. In Leinhardt, S. (Ed.), Sociological methodology (pp. 290–312). Washington, DC: American Sociological Association.Google Scholar
Sroufe, L. A. (1997). Psychopathology as an outcome of development. Development and Psychopathology, 9, 251–268.CrossRefGoogle ScholarPubMed
Sroufe, L. A., & Fleeson, J. (1986). Attachment and the construction of relationships. In Hartup, W. & Rubin, Z. (Eds.), Relationships and development (pp. 51–71). Hillsdale, NJ: Erlbaum.Google Scholar
Sroufe, L. A., & Fleeson, J. (1988). The coherence of family relationships. In Hinde, R. A. & Stevenson-Hinde, J. (Eds.), Relationships within families: Mutual influences (pp. 27–47). Oxford: Oxford University Press.Google Scholar
Sroufe, L. A., & Rutter, M. (1984). The domain of developmental psychopathology. Child Development, 55, 17–29.CrossRefGoogle ScholarPubMed
Storch, E. A., Nock, M. K., Masia-Warner, C., & Barlas, M. E. (2003). Peer victimization and social–psychological adjustment in Hispanic and African-American children. Journal of Child and Family Studies, 12, 439–452.CrossRefGoogle Scholar
Stouthamer-Loeber, M., Loeber, R., Homish, D. L., & Wei, E. (2001). Maltreatment of boys and the development of disruptive and delinquent behavior. Development and Psychopathology, 13, 941–955.CrossRefGoogle ScholarPubMed
Sugden, K., Arseneault, L., Harrington, H., Moffitt, T. E., Williams, B., & Caspi, A. (2010). Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. Child & Adolescent Psychiatry, 49, 830–840.Google ScholarPubMed
Surtees, P. G., Wainwright, N. W., Willis-Owen, S. A., Luben, R., Day, N. E., & Flint, J. (2006). Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biological Psychiatry, 59, 224–229.CrossRefGoogle ScholarPubMed
Teisl, M., & Cicchetti, D. (2008). Physical abuse, cognitive and emotional processes, and aggressive/disruptive behavior problems. Social Development, 17, 1–23.CrossRefGoogle Scholar
Toth, S. L., Manly, J. T., & Cicchetti, D. (1992). Child maltreatment and vulnerability to depression. Development and Psychopathology, 4, 97–112.CrossRefGoogle Scholar
Toth, S. L., Maughan, A., Manly, J. D., Spagnola, M., & Cicchetti, D. (2002). The relative efficacy of two interventions in altering maltreated preschool children's representational models: Implications for attachment theory. Development and Psychopathology, 14, 877–908.CrossRefGoogle ScholarPubMed
Trickett, P. K., & McBride-Chang, C. (1995). The developmental impact of different types of child abuse and neglect. Developmental Review, 15, 311–337.CrossRefGoogle Scholar
Troy, M., & Sroufe, L. A. (1987). Victimization among preschoolers: Role of attachment relationship history. Journal of the American Academy of Child & Adolescent Psychiatry, 26, 166–172.CrossRefGoogle ScholarPubMed
Uher, R., Caspi, A., Houts, R., Sugden, K., Williams, B., Poulton, R., et al. (2011). Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: Replications and implications for resolving inconsistent results. Journal of Affective Disorders, 135, 56–65.CrossRefGoogle Scholar
Uher, R., & McGuffin, P. (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry, 15, 18–22.CrossRefGoogle ScholarPubMed
Vernberg, E. M. (1990). Psychological adjustment and experiences with peers during early adolescence: Reciprocal, incidental, or unidirectional relationships? Journal of Abnormal Child Psychology, 18, 187–198.CrossRefGoogle ScholarPubMed
Waters, E., & Sroufe, L. A. (1983). Social competence as a developmental construct. Developmental Review, 3, 79–97.CrossRefGoogle Scholar
Wichers, M., Kenis, G., Jacobs, N., Mengelers, R., Derom, C., Vlietinck, R., et al. (2008). The BDNF Val(66)Met × 5-HTTLPR × Child Adversity interaction and depressive symptoms: An attempt at replication. American Journal of Medical Genetics, 147B, 120–123.Google ScholarPubMed
Widom, C. S., DuMont, K., & Czaja, S. J. (2007). A prospective investigation of major depressive disorder and co-morbidity in abused and neglected grown up children (grown up). Archives of General Psychiatry, 64, 49–56.CrossRefGoogle ScholarPubMed
Youngstrom, E., Loeber, R., & Stouthamer-Loeber, M. (2000). Patterns and correlates of agreement between parent, teacher, and male adolescent ratings of externalizing and internalizing problems. Journal of Consulting and Clinical Psychology, 68, 1038–1050.CrossRefGoogle ScholarPubMed
Zhang, K., Xu, Q., Xu, Y., Yang, H., Luo, J., Sun, Y., et al. (2009). The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population. Journal of Affective Disorders, 114, 224–231.CrossRefGoogle ScholarPubMed