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Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation

Published online by Cambridge University Press:  07 October 2019

Meghan Huang*
Affiliation:
Department of Clinical and Social Sciences in Psychology, University of Rochester, Rochester, NY, USA
Lisa R. Starr
Affiliation:
Department of Clinical and Social Sciences in Psychology, University of Rochester, Rochester, NY, USA
*
Author for Correspondence: Meghan Huang, 494 Meliora Hall, Box 270266, Rochester, NY 14627; E-mail: meghan.huang@rochester.edu.

Abstract

Research suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current study, we applied a multilocus genetic profile score (MGPS) approach to measuring HPA axis-related genetic variation and examined its interaction with ICA to predict interpersonal stress generation in a sample of adolescents aged 14–17 (N = 241, Caucasian subsample n = 192). MGPSs were computed using 10 single nucleotide polymorphisms from HPA axis-related genes (CRHR1, NRC31, NRC32, and FKBP5). ICA significantly predicted greater adolescent interpersonal dependent stress. Additionally, MGPS predicted a stronger association between ICA and interpersonal dependent (but not independent or noninterpersonal dependent) stress. No gene–environment interaction (G×E) effects were found for noninterpersonal CA and MGPS in predicting adolescent interpersonal dependent stress. Effects remained after controlling for current depressive symptoms and following stratification by race. Findings extend existing G×E research on stress generation to HPA axis-related genetic variation and demonstrate effects specific to the interpersonal domain.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2019

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References

Aliev, F., Latendresse, S. J., Bacanu, S.-A., Neale, M. C., & Dick, D. M. (2014). Testing for measured gene-environment interaction: Problems with the use of cross-product terms and a regression model reparameterization solution. Behavior Genetics, 44, 165181.CrossRefGoogle Scholar
Alloy, L. B., Liu, R. T., & Bender, R. E. (2010). Stress generation research in depression: A commentary. International Journal of Cognitive Therapy, 3, 380388.CrossRefGoogle ScholarPubMed
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., … Giles, W. H. (2006). The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience, 256, 174186. doi:10.1007/s00406-005-0624-4CrossRefGoogle ScholarPubMed
Arnau-Soler, A., Macdonald-Dunlop, E., Adams, M. J., Clarke, T. K., MacIntyre, D. J., Milburn, K., … Thomson, P. A. (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9, 14. doi: 10.1038/s41398-018-0360-yCrossRefGoogle ScholarPubMed
Avenevoli, S., Swendsen, J., He, J.-P., Burstein, M., & Merikangas, K. R. (2015). Major depression in the National Comorbidity Survey–Adolescent Supplement: Prevalence, correlates, and treatment. Journal of the American Academy of Child & Adolescent Psychiatry, 54, 3744.e32. doi:https://doi.org/10.1016/j.jaac.2014.10.010CrossRefGoogle ScholarPubMed
Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse. Current Directions in Psychological Science, 16, 300304. doi:10.1111/j.1467-8721.2007.00525.xCrossRefGoogle Scholar
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885908.CrossRefGoogle ScholarPubMed
Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological), 57, 289300.CrossRefGoogle Scholar
Bogdan, R., Baranger, D. A. A., & Agrawal, A. (2018). Polygenic risk scores in clinical psychology: Bridging genomic risk to individual differences. Annual Review of Clinical Psychology, 14, 119157. doi:10.1146/annurev-clinpsy-050817-084847CrossRefGoogle ScholarPubMed
Bowlby, J. (1982). Attachment and loss: Retrospect and prospect. American Journal of Orthopsychiatry, 52, 664678.CrossRefGoogle ScholarPubMed
Brown, G. W., & Harris, T. (2012). Social origins of depression: A study of psychiatric disorder in women. London: Routledge.CrossRefGoogle Scholar
Buchmann, A. F., Holz, N., Boecker, R., Blomeyer, D., Rietschel, M., Witt, S. H., … Laucht, M. (2014). Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood. European Neuropsychopharmacology, 24, 837845. doi:10.1016/j.euroneuro.2013.12.001CrossRefGoogle ScholarPubMed
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509527. doi:10.1176/appi.ajp.2010.09101452CrossRefGoogle ScholarPubMed
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386389. doi:10.1126/science.1083968CrossRefGoogle ScholarPubMed
Chan, P. T., Doan, S. N., & Tompson, M. C. (2014). Stress generation in a developmental context: The role of youth depressive symptoms, maternal depression, the parent–child relationship, and family stress. Journal of Family Psychology, 28, 3241. doi:10.1037/a0035277CrossRefGoogle Scholar
Chen, F. R., Stroud, C. B., Vrshek-Schallhorn, S., Doane, L. D., & Granger, D. A. (2017). Individual differences in early adolescents' latent trait cortisol: Interaction of early adversity and 5-HTTLPR. Biological Psychology, 129, 815. doi:10.1016/j.biopsycho.2017.07.017CrossRefGoogle ScholarPubMed
Cicchetti, D., & Rogosch, F. A. (2012). Neuroendocrine regulation and emotional adaptation in the context of child maltreatment. Monographs of the Society for Research in Child Development, 77, 8795. doi:doi:10.1111/j.1540-5834.2011.00666.xCrossRefGoogle Scholar
Cicchetti, D., Rogosch, F. A., & Oshri, A. (2011). Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Development and Psychopathology, 23, 11251138. doi:10.1017/s0954579411000599CrossRefGoogle ScholarPubMed
Conway, C. C., Hammen, C., Brennan, P. A., Lind, P. A., & Najman, J. M. (2010). Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression. Depression and Anxiety, 27, 737745. doi:10.1002/da.20715CrossRefGoogle ScholarPubMed
Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., … Bierut, L. J. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23, 133142. doi:10.1038/mp.2017.44CrossRefGoogle Scholar
Derijk, R. H. (2009). Single nucleotide polymorphisms related to HPA axis reactivity. Neuroimmunomodulation, 16, 340352. doi:10.1159/000216192CrossRefGoogle ScholarPubMed
de Vries, Y. A., Roest, A. M., Franzen, M., Munafo, M. R., & Bastiaansen, J. A. (2016). Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression. Psychological Medicine, 46, 29712979. doi:10.1017/s0033291716000805CrossRefGoogle Scholar
Dick, D. M., Agrawal, A., Keller, M. C., Adkins, A., Aliev, F., Monroe, S., … Sher, K. J. (2015). Candidate gene-environment interaction research: reflections and recommendations. Perspectives on Psychological Science, 10, 3759. doi:10.1177/1745691614556682CrossRefGoogle ScholarPubMed
Di Iorio, C. R., Carey, C. E., Michalski, L. J., Corral-Frias, N. S., Conley, E. D., Hariri, A. R., & Bogdan, R. (2017). Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function. Psychoneuroendocrinology, 80, 170178. doi:10.1016/j.psyneuen.2017.03.016CrossRefGoogle ScholarPubMed
Dodge, K. A., Bates, J. E., & Pettit, G. S. (1990). Mechanisms in the cycle of violence. Science, 250, 16781683.CrossRefGoogle ScholarPubMed
Downey, G., Freitas, A. L., Michaelis, B., & Khouri, H. (1998). The self-fulfilling prophecy in close relationships: Rejection sensitivity and rejection by romantic partners. Journal of Personality and Social Psychology, 75, 545560.CrossRefGoogle ScholarPubMed
Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 10411049. doi:10.1176/appi.ajp.2011.11020191CrossRefGoogle Scholar
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., … Marks, J. S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14, 245258.CrossRefGoogle ScholarPubMed
Feurer, C., McGeary, J. E., Knopik, V. S., Brick, L. A., Palmer, R. H., & Gibb, B. E. (2017). HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers. Journal of Abnormal Psychology, 126, 10171028. doi:10.1037/abn0000316CrossRefGoogle ScholarPubMed
Flynn, M., & Rudolph, K. D. (2011). Stress generation and adolescent depression: contribution of interpersonal stress responses. Journal of Abnormal Child Psychology, 39, 11871198. doi:10.1007/s10802-011-9527-1CrossRefGoogle ScholarPubMed
George, D., & Mallery, M. (2010). SPSS for windows step by step: A simple guide and reference, 17.0 update (10a ed.). Boston: Pearson.Google Scholar
Gerritsen, L., Milaneschi, Y., Vinkers, C. H., van Hemert, A. M., van Velzen, L., Schmaal, L., & Penninx, B. W. (2017). HPA axis genes, and their interaction with childhood maltreatment, are related to cortisol levels and stress-related phenotypes. Neuropsychopharmacology, 42, 24462455. doi:10.1038/npp.2017.118CrossRefGoogle ScholarPubMed
Green, J. G., McLaughlin, K. A., Berglund, P. A., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010). Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: Associations with first onset of DSM-IV disorders. Archives of General Psychiatry, 67, 113123. doi:10.1001/archgenpsychiatry.2009.186CrossRefGoogle ScholarPubMed
Guerry, J. D., & Hastings, P. D. (2011). In search of HPA axis dysregulation in child and adolescent depression. Clinical Child and Family Psychology Review, 14, 135160. doi:10.1007/s10567-011-0084-5CrossRefGoogle ScholarPubMed
Gunnar, M., & Quevedo, K. (2007). The neurobiology of stress and development. Annual Review of Psychology, 58, 145173. doi:10.1146/annurev.psych.58.110405.085605CrossRefGoogle Scholar
Gunnar, M. R., & Vazquez, D. (2006). Developmental psychopathology: Developmental Neuroscience (Vol. 2, pp. 533577). Hoboken, NJ: Wiley.Google Scholar
Gunnar, M., Wewerka, S., Frenn, K., Long, J. D., & Griggs, C. (2009). Developmental changes in hypothalamus-pituitary-adrenal activity over the transition to adolescence: Normative changes and associations with puberty. Development and Psychopathology, 21, 6985. doi:10.1017/s0954579409000054CrossRefGoogle ScholarPubMed
Hames, J. L., Hagan, C. R., & Joiner, T. E. (2013). Interpersonal processes in depression. Annual Review of Clinical Psychology, 9, 355377. doi:10.1146/annurev-clinpsy-050212-185553CrossRefGoogle ScholarPubMed
Hammen, C. (1991). Generation of stress in the course of unipolar depression. Journal of Abnormal Psychology, 100, 555561.CrossRefGoogle ScholarPubMed
Hammen, C. (2006). Stress generation in depression: Reflections on origins, research, and future directions. Journal of Clinical Psychology, 62, 10651082. doi:10.1002/jclp.20293CrossRefGoogle ScholarPubMed
Hammen, C., Henry, R., & Daley, S. E. (2000). Depression and sensitization to stressors among young women as a function of childhood adversity. Journal of Consulting and Clinical Psychology, 68, 782787.CrossRefGoogle ScholarPubMed
Hankin, B. L. (2005). Childhood maltreatment and psychopathology: Prospective tests of attachment, cognitive vulnerability, and stress as mediating processes. Cognitive Therapy and Research, 29, 645671. doi:10.1007/s10608-005-9631-zCrossRefGoogle Scholar
Harkness, K. L., Bagby, R. M., Stewart, J. G., Larocque, C. L., Mazurka, R., Strauss, J. S., … Kennedy, J. L. (2015). Childhood emotional and sexual maltreatment moderate the relation of the serotonin transporter gene to stress generation. Journal of Abnormal Psychology, 124, 275287. doi:10.1037/abn0000034CrossRefGoogle ScholarPubMed
Harkness, K. L., Lumley, M. N., & Truss, A. E. (2008). Stress generation in adolescent depression: The moderating role of child abuse and neglect. Journal of Abnormal Child Psychology, 36, 421432. doi:10.1007/s10802-007-9188-2CrossRefGoogle ScholarPubMed
Hayes, A. F. (2017). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach: Guilford Publications.Google Scholar
Hazel, N. A., Hammen, C., Brennan, P. A., & Najman, J. (2008). Early childhood adversity and adolescent depression: The mediating role of continued stress. Psychological Medicine, 38, 581589. doi:10.1017/s0033291708002857CrossRefGoogle ScholarPubMed
Heim, C., Bradley, B., Mletzko, T. C., Deveau, T. C., Musselman, D. L., Nemeroff, C. B., … Binder, E. B. (2009). Effect of childhood trauma on adult depression and neuroendocrine function: Sex-specific moderation by CRH receptor 1 gene. Frontiers in Behavioral Neuroscience, 3. doi: 10.3389/neuro.08.041.2009CrossRefGoogle ScholarPubMed
Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49, 10231039.CrossRefGoogle ScholarPubMed
Hernandez, E. M., Trout, Z. M., & Liu, R. T. (2016). Vulnerability-specific stress generation: Childhood emotional abuse and the mediating role of depressogenic interpersonal processes. Child Abuse and Neglect, 62, 132141. doi:10.1016/j.chiabu.2016.10.019CrossRefGoogle ScholarPubMed
Huh, H. J., Kim, S. Y., Yu, J. J., & Chae, J. H. (2014). Childhood trauma and adult interpersonal relationship problems in patients with depression and anxiety disorders. Annals of General Psychiatry, 13. doi: 10.1186/s12991-014-0026-yCrossRefGoogle ScholarPubMed
Johnson, J. G., Cohen, P., Gould, M. S., Kasen, S., Brown, J., & Brook, J. S. (2002). Childhood adversities, interpersonal difficulties, and risk for suicide attempts during late adolescence and early adulthood. Archives of General Psychiatry, 59, 741749.CrossRefGoogle ScholarPubMed
Joiner, T. E., & Timmons, K. A. (2002). Depression in its interpersonal context. Handbook of depression, 2, 322339.Google Scholar
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444454. doi:10.1001/archgenpsychiatry.2010.189CrossRefGoogle ScholarPubMed
Kaufman, J., Birmaher, B., Brent, D., Rao, U. M. A., Flynn, C., Moreci, P., … Ryan, N. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980988. doi: http://dx.doi.org/10.1097/00004583-199707000-00021CrossRefGoogle ScholarPubMed
Kendler, K. S., & Karkowski-Shuman, L. (1997). Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment? Psychological Medicine, 27, 539547.CrossRefGoogle ScholarPubMed
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry, 156, 837841. doi:10.1176/ajp.156.6.837CrossRefGoogle ScholarPubMed
Kim, J. H., Martins, S. S., Shmulewitz, D., Santaella, J., Wall, M. M., Keyes, K. M., … Hasin, D. S. (2014). Childhood maltreatment, stressful life events, and alcohol craving in adult drinkers. Alcoholism: Clinical and Experimental Research, 38, 20482055. doi:10.1111/acer.12473CrossRefGoogle ScholarPubMed
Kuras, Y. I., Assaf, N., Thoma, M. V., Gianferante, D., Hanlin, L., Chen, X., … Rohleder, N. (2017). Blunted diurnal cortisol activity in healthy adults with childhood adversity. Frontiers in Human Neuroscience, 11, 574. doi:10.3389/fnhum.2017.00574CrossRefGoogle ScholarPubMed
Kushner, S. C., Bagby, R. M., & Harkness, K. L. (2017). Stress generation in adolescence: Contributions from five-factor model (FFM) personality traits and childhood maltreatment. Personality Disorders: Theory, Research, and Treatment, 8, 150161. doi:10.1037/per0000194CrossRefGoogle ScholarPubMed
Lahey, B. B. (2009). Public health significance of neuroticism. American Psychologist, 64, 241256. doi:10.1037/a0015309CrossRefGoogle ScholarPubMed
La Rocque, C. L., Harkness, K. L., & Bagby, R. M. (2014). The differential relation of childhood maltreatment to stress sensitization in adolescent and young adult depression. Journal of Adolescence, 37, 871882. doi:10.1016/j.adolescence.2014.05.012CrossRefGoogle ScholarPubMed
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmidt, M. H., Esser, G., … Banaschewski, T. (2013). Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: Findings from a longitudinal study. European Neuropsychopharmacology, 23, 358367. doi:10.1016/j.euroneuro.2012.06.002CrossRefGoogle ScholarPubMed
Liu, R. T., & Alloy, L. B. (2010). Stress generation in depression: A systematic review of the empirical literature and recommendations for future study. Clinical Psychology Review, 30, 582593. doi:10.1016/j.cpr.2010.04.010CrossRefGoogle ScholarPubMed
Liu, R. T., Choi, J. Y., Boland, E. M., Mastin, B. M., & Alloy, L. B. (2013). Childhood abuse and stress generation: The mediational effect of depressogenic cognitive styles. Psychiatry Research, 206, 217222. doi:10.1016/j.psychres.2012.12.001CrossRefGoogle ScholarPubMed
Luijk, M. P., Velders, F. P., Tharner, A., van Ijzendoorn, M. H., Bakermans-Kranenburg, M. J., Jaddoe, V. W., … Tiemeier, H. (2010). FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction. Psychoneuroendocrinology, 35, 14541461. doi:10.1016/j.psyneuen.2010.04.012CrossRefGoogle ScholarPubMed
Mahon, P. B., Zandi, P. P., Potash, J. B., Nestadt, G., & Wand, G. S. (2013). Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults. Psychopharmacology, 227, 231241. doi:10.1007/s00213-012-2956-xCrossRefGoogle ScholarPubMed
Manuck, S. B., & McCaffery, J. M. (2014). Gene-environment interaction. Annual Review of Psychology, 65, 4170. doi:10.1146/annurev-psych-010213-115100CrossRefGoogle ScholarPubMed
Massing-Schaffer, M., Liu, R. T., Kraines, M. A., Choi, J. Y., & Alloy, L. B. (2015). Elucidating the relation between childhood emotional abuse and depressive symptoms in adulthood: The mediating role of maladaptive interpersonal processes. Personality and Individual Differences, 74, 106111. doi:10.1016/j.paid.2014.09.045CrossRefGoogle ScholarPubMed
Masten, A. S., Best, K. M., & Garmezy, N. (1990). Resilience and development: Contributions from the study of children who overcome adversity. Development and Psychopathology, 2, 425444. doi:10.1017/S0954579400005812CrossRefGoogle Scholar
Masten, A. S., Hubbard, J. J., Gest, S. D., Tellegen, A., Garmezy, N., & Ramirez, M. (1999). Competence in the context of adversity: Pathways to resilience and maladaptation from childhood to late adolescence. Development and Psychopathology, 11, 143169.CrossRefGoogle ScholarPubMed
McEwen, B. S. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 3344.CrossRefGoogle ScholarPubMed
McLaughlin, K. A. (2016). Future directions in childhood adversity and youth psychopathology. Journal of Clinical Child and Adolescent Psychology, 45, 361382. doi:10.1080/15374416.2015.1110823CrossRefGoogle ScholarPubMed
McLaughlin, K. A., Conron, K. J., Koenen, K. C., & Gilman, S. E. (2010). Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: A test of the stress sensitization hypothesis in a population-based sample of adults. Psychological Medicine, 40, 16471658. doi:doi:10.1017/S0033291709992121CrossRefGoogle Scholar
Mickelson, K. D., Kessler, R. C., & Shaver, P. R. (1997). Adult attachment in a nationally representative sample. Journal of Personality and Social Psychology, 73, 10921106.CrossRefGoogle Scholar
Miller, G. E., Chen, E., & Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological bulletin, 133, 2545.CrossRefGoogle ScholarPubMed
Monroe, S. M., & Harkness, K. L. (2005). Life stress, the “kindling” hypothesis, and the recurrence of depression: Considerations from a life stress perspective. Psychological Review, 112, 417445. doi:10.1037/0033-295x.112.2.417CrossRefGoogle ScholarPubMed
Morris, M. C., Kouros, C. D., Hellman, N., Rao, U., & Garber, J. (2014). Two prospective studies of changes in stress generation across depressive episodes in adolescents and emerging adults. Development and Psychopathology, 26, 13851400. doi:10.1017/s0954579414001096CrossRefGoogle ScholarPubMed
Musliner, K. L., Seifuddin, F., Judy, J. A., Pirooznia, M., Goes, F. S., & Zandi, P. P. (2015). Polygenic risk, stressful life events and depressive symptoms in older adults: A polygenic score analysis. Psychological Medicine, 45, 17091720. doi:10.1017/S0033291714002839CrossRefGoogle ScholarPubMed
Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2011). Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology, 36, 19401947. doi:10.1038/npp.2011.82CrossRefGoogle ScholarPubMed
Pagliaccio, D., Luby, J. L., Bogdan, R., Agrawal, A., Gaffrey, M. S., Belden, A. C., … Barch, D. M. (2014). Stress-system genes and life stress predict cortisol levels and amygdala and hippocampal volumes in children. Neuropsychopharmacology, 39, 12451253. doi:10.1038/npp.2013.327CrossRefGoogle ScholarPubMed
Pagliaccio, D., Luby, J. L., Bogdan, R., Agrawal, A., Gaffrey, M. S., Belden, A. C., … Barch, D. M. (2015). Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation. Journal of Abnormal Psychology, 124, 817833. doi:10.1037/abn0000094CrossRefGoogle ScholarPubMed
Petersen, A. C., Crockett, L., Richards, M., & Boxer, A. (1988). A self-report measure of pubertal status: Reliability, validity, and initial norms. Journal of Youth and Adolescence, 17, 117133.CrossRefGoogle ScholarPubMed
Plomin, R., DeFries, J. C., & Loehlin, J. C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309322. doi:10.1037/0033-2909.84.2.309CrossRefGoogle ScholarPubMed
Post, R. M. (1992). Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. American Journal of Psychiatry, 149, 9991010.Google ScholarPubMed
Rao, U. M. A., Daley, S. E., & Hammen, C. (2000). Relationship between depression and substance use disorders in adolescent women during the transition to adulthood. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 215222. doi: http://dx.doi.org/10.1097/00004583-200002000-00022CrossRefGoogle ScholarPubMed
Rice, F., Harold, G. T., & Thapar, A. (2002). Assessing the effects of age, sex and shared environment on the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry, 43, 10391051. doi:10.1111/1469-7610.00231CrossRefGoogle ScholarPubMed
Romeo, R. D. (2013). The teenage brain: The stress response and the adolescent brain. Current Directions in Psychological Science, 22, 140145. doi:10.1177/0963721413475445CrossRefGoogle ScholarPubMed
Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., & Enoch, M. A. (2010). Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology, 35, 16741683. doi:10.1038/npp.2009.236CrossRefGoogle ScholarPubMed
Rudolph, K. D. (2002). Gender differences in emotional responses to interpersonal stress during adolescence. Journal of Adolescent Health, 30, 313.CrossRefGoogle ScholarPubMed
Rudolph, K. D., Hammen, C., Burge, D., Lindberg, N., Herzberg, D., & Daley, S. E. (2000). Toward an interpersonal life-stress model of depression: The developmental context of stress generation. Development and Psychopathology, 12, 215234.CrossRefGoogle ScholarPubMed
Salwen, J. K., Hymowitz, G. F., Vivian, D., & O'Leary, K. D. (2014). Childhood abuse, adult interpersonal abuse, and depression in individuals with extreme obesity. Child Abuse and Neglect, 38, 425433. doi:10.1016/j.chiabu.2013.12.005CrossRefGoogle ScholarPubMed
Scarr, S., & McCartney, K. (1983). How people make their own environments: A theory of genotype greater than environment effects. Child Development, 54, 424435.Google ScholarPubMed
Shapero, B. G., Black, S. K., Liu, R. T., Klugman, J., Bender, R. E., Abramson, L. Y., & Alloy, L. B. (2014). Stressful life events and depression symptoms: The effect of childhood emotional abuse on stress reactivity. Journal of Clinical Psychology, 70, 209223. doi:10.1002/jclp.22011CrossRefGoogle ScholarPubMed
Sheikh, H. I., Kryski, K. R., Smith, H. J., Hayden, E. P., & Singh, S. M. (2013). Corticotropin-releasing hormone system polymorphisms are associated with children's cortisol reactivity. Neuroscience, 229, 111. doi:10.1016/j.neuroscience.2012.10.056CrossRefGoogle ScholarPubMed
Shih, J. H., Abela, J. R., & Starrs, C. (2009). Cognitive and interpersonal predictors of stress generation in children of affectively ill parents. Journal of Abnormal Child Psychology, 37, 195208. doi:10.1007/s10802-008-9267-zCrossRefGoogle ScholarPubMed
Shih, J. H., Eberhart, N. K., Hammen, C. L., & Brennan, P. A. (2006). Differential exposure and reactivity to interpersonal stress predict sex differences in adolescent depression. Journal of Clinical Child and Adolescent Psychology, 35, 103115. doi:10.1207/s15374424jccp3501_9CrossRefGoogle ScholarPubMed
Spangler, G., Johann, M., Ronai, Z., & Zimmermann, P. (2009). Genetic and environmental influence on attachment disorganization. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50, 952961.CrossRefGoogle ScholarPubMed
Sroufe, L. A. (2000). Early relationships and the development of children. Infant Mental Health Journal, 21, 6774. doi:10.1002/(SICI)1097-0355(200001/04)21:1/2<67::AID-IMHJ8>3.0.CO;2-23.0.CO;2-2>CrossRefGoogle Scholar
Starr, L. R., Dienes, K., Li, Y. I., & Shaw, Z. A. (2019). Chronic stress exposure, diurnal cortisol slope, and implications for mood and fatigue: Moderation by multilocus HPA-Axis genetic variation. Psychoneuroendocrinology, 100, 156163. doi: https://doi.org/10.1016/j.psyneuen.2018.10.003CrossRefGoogle ScholarPubMed
Starr, L. R., Dienes, K., Stroud, C. B., Shaw, Z. A., Li, Y. I., Mlawer, F., & Huang, M. (2017). Childhood adversity moderates the influence of proximal episodic stress on the cortisol awakening response and depressive symptoms in adolescents. Development and Psychopathology, 29, 18771893. doi:10.1017/s0954579417001468CrossRefGoogle ScholarPubMed
Starr, L. R., Hammen, C., Brennan, P. A., & Najman, J. M. (2012). Serotonin transporter gene as a predictor of stress generation in depression. Journal of Abnormal Psychology, 121, 810818. doi:10.1037/a0027952CrossRefGoogle ScholarPubMed
Starr, L. R., Hammen, C., Brennan, P. A., & Najman, J. M. (2013). Relational security moderates the effect of serotonin transporter gene polymorphism (5-HTTLPR) on stress generation and depression among adolescents. Journal of Abnormal Child Psychology, 41, 379388. doi:10.1007/s10802-012-9682-zCrossRefGoogle ScholarPubMed
Starr, L. R., Hammen, C., Conway, C. C., Raposa, E., & Brennan, P. A. (2014). Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. Development and Psychopathology, 26, 12411254. doi:10.1017/s0954579414000996CrossRefGoogle Scholar
Starr, L. R., & Huang, M. (2019). HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents. Development and Psychopathology, 31, 13391352. doi:10.1017/S0954579418000779.CrossRefGoogle ScholarPubMed
Steinberg, S. J., & Davila, J. (2008). Romantic functioning and depressive symptoms among early adolescent girls: The moderating role of parental emotional availability. Journal of Clinical Child and Adolescent Psychology, 37, 350362.CrossRefGoogle Scholar
Stroud, C. B., Chen, F. R., Doane, L. D., & Granger, D. A. (2016). Individual differences in early adolescents' latent trait cortisol (LTC): Relation to early adversity. Developmental Psychobiology, 58, 700713. doi:10.1002/dev.21410CrossRefGoogle ScholarPubMed
Styron, T., & Janoff-Bulman, R. (1997). Childhood attachment and abuse: Long-term effects on adult attachment, depression, and conflict resolution. Child Abuse and Neglect, 21, 10151023.CrossRefGoogle ScholarPubMed
Sumner, J. A., McLaughlin, K. A., Walsh, K., Sheridan, M. A., & Koenen, K. C. (2014). CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents. Psychoneuroendocrinology, 43, 7180. doi:10.1016/j.psyneuen.2014.02.002CrossRefGoogle ScholarPubMed
Swartz, J. R., Knodt, A. R., Radtke, S. R., & Hariri, A. R. (2015). A neural biomarker of psychological vulnerability to future life stress. Neuron, 85, 505511. doi:10.1016/j.neuron.2014.12.055CrossRefGoogle ScholarPubMed
Tarullo, A. R., & Gunnar, M. (2006). Child maltreatment and the developing HPA axis. Hormones and Behavior, 50, 632639. doi:10.1016/j.yhbeh.2006.06.010CrossRefGoogle ScholarPubMed
Troop-Gordon, W., Sugimura, N., & Rudolph, K. D. (2017). Responses to interpersonal stress: Normative changes across childhood and the impact of peer victimization. Child Development, 88, 640657. doi:10.1111/cdev.12617CrossRefGoogle ScholarPubMed
Tully, E. C., Iacono, W. G., & McGue, M. (2010). Changes in genetic and environmental influences on the development of nicotine dependence and major depressive disorder from middle adolescence to early adulthood. Development and Psychopathology, 22, 831848. doi:10.1017/S0954579410000490CrossRefGoogle ScholarPubMed
Uhrlass, D. J., & Gibb, B. E. (2007). Childhood emotional maltreatment and the stress generation model of depression. Journal of Social and Clinical Psychology, 26, 119130. doi:10.1521/jscp.2007.26.1.119CrossRefGoogle Scholar
Uliaszek, A. A., Zinbarg, R. E., Mineka, S., Craske, M. G., Griffith, J. W., Sutton, J. M., … Hammen, C. (2012). A longitudinal examination of stress generation in depressive and anxiety disorders. Journal of Abnormal Psychology, 121, 415. doi:10.1037/a0025835CrossRefGoogle ScholarPubMed
Vrshek-Schallhorn, S., Sapuram, V., & Avery, B. M. (2017). Letter to the editor: Bias in the measurement of bias. Letter regarding ‘Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression’. Psychological Medicine, 47, 187192. doi:10.1017/s0033291716002178CrossRefGoogle Scholar
Vrshek-Schallhorn, S., Stroud, C. B., Mineka, S., Zinbarg, R. E., Adam, E. K., Redei, E. E., … Craske, M. G. (2015). Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. Journal of Abnormal Psychology, 124, 776790. doi:10.1037/abn0000098CrossRefGoogle ScholarPubMed
Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Farrer, L. A., & Gelernter, J. (2010). Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology, 35, 16841692. doi:10.1038/npp.2010.37CrossRefGoogle ScholarPubMed
Zannas, A. S., & Binder, E. B. (2014). Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. Genes, Brain and Behavior, 13, 2537. doi:10.1111/gbb.12104CrossRefGoogle ScholarPubMed