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Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths

Published online by Cambridge University Press:  14 June 2016

Matthew D. Albaugh ,
Simon Ducharme ,
Sherif Karama ,
Richard Watts ,
John D. Lewis ,
Catherine Orr ,
Tuong-Vi Nguyen ,
Robert C. Mckinstry ,
Kelly N. Botteron  and
Alan C. Evans
...Show all authors
Matthew D. Albaugh*
Affiliation:
University of Vermont College of Medicine
Simon Ducharme
Affiliation:
McGill University
Sherif Karama
Affiliation:
McGill University
Richard Watts
Affiliation:
University of Vermont College of Medicine
John D. Lewis
Affiliation:
McGill University
Catherine Orr
Affiliation:
University of Vermont College of Medicine
Tuong-Vi Nguyen
Affiliation:
McGill University
Robert C. Mckinstry
Affiliation:
Washington University in St. Louis School of Medicine
Kelly N. Botteron
Affiliation:
Washington University in St. Louis School of Medicine
Alan C. Evans
Affiliation:
McGill University
James J. Hudziak
Affiliation:
University of Vermont College of Medicine
*
Address correspondence and reprint requests to: Matthew D. Albaugh, Vermont Center for Children, Youth and Families, University of Vermont College of Medicine, University Health Center Campus, 1 South Prospect Street, Burlington, VT 05401; E-mail: malbaugh@uvm.edu.
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Abstract

There are multiple recent reports of an association between anxious/depressed (A/D) symptomatology and the rate of cerebral cortical thickness maturation in typically developing youths. We investigated the degree to which anxious/depressed symptoms are tied to age-related microstructural changes in cerebral fiber pathways. The participants were part of the NIH MRI Study of Normal Brain Development. Child Behavior Checklist A/D scores and diffusion imaging were available for 175 youths (84 males, 91 females; 241 magnetic resonance imagings) at up to three visits. The participants ranged from 5.7 to 18.4 years of age at the time of the scan. Alignment of fractional anisotropy data was implemented using FSL/Tract-Based Spatial Statistics, and linear mixed model regression was carried out using SPSS. Child Behavior Checklist A/D was associated with the rate of microstructural development in several white matter pathways, including the bilateral anterior thalamic radiation, bilateral inferior longitudinal fasciculus, left superior longitudinal fasciculus, and right cingulum. Across these pathways, greater age-related fractional anisotropy increases were observed at lower levels of A/D. The results suggest that subclinical A/D symptoms are associated with the rate of microstructural development within several white matter pathways that have been implicated in affect regulation, as well as mood and anxiety psychopathology.

Type
Regular Articles
Information
Development and Psychopathology , Volume 29 , Issue 3 , August 2017 , pp. 751 - 758
Copyright
Copyright © Cambridge University Press 2016 

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Footnotes

This project was funded in whole or in part with federal funds from the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke (Contract Numbers N01-HD02-3343, N01-MH9-0002, N01-NS-9-2314, N01-NS-9-2315, N01-NS-9-2316, N01-NS-9-2317, N01-NS-9-2319, and N01-NS-9-2320). Key personnel from the six pediatric study centers may be found online at http://www.nih-pediatricmri.org. Dr. Albaugh is funded by a grant from the Child and Adolescent Psychology Training and Research Foundation, Dr. Ducharme has received funding from the Fonds de Recherche du Québec-Santé and the Montreal General Hospital Foundation, and Dr. Karama is supported by the Fonds de Recherche en Santé du Québec. The authors report no biomedical financial interests or potential conflicts of interest related to this article. The views herein do not necessarily represent the official views of the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institutes of Health, the US Department of Health and Human Services, or any other agency of the United States government.

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