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Odor Identification Impairments in Schizophrenia: Relationship With Demographic Measures, Clinical Variables, and Diagnostic Subtypes

Published online by Cambridge University Press:  07 November 2014

Abstract

Smell identification deficits are consistently found in schizophrenia (SZ), but little is known about the nature and characterization of this deficit or its relationship to the phenomenology of the illness. This study aims to further delineate smell identification errors in SZ by examining the relationship of patient demographic differences with smell-identification performance. Our results showed that a patient's gender and education were related to odor-identification scores, with better performance seen in female patients and in those with greater educational attainment. However, there was no effect related to age, ethnicity, or socioeconomic status on odor identification. A smell identification deficit was also unrelated to clinical characteristics of the patients, including age at first hospitalization, number of psychiatric hospitalizations, and duration of illness. Odor identification also did not differ by SZ subtype, nor between SZ and schizoaffective disorder patients. These findings emphasize that odor identification deficits in SZ are unrelated to clinical illness features, cannot be explained by other confounds related to olfaction in the general population, and may be core features related to the SZ disease process.

Type
Original Research
Copyright
Copyright © Cambridge University Press 2002

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References

REFERENCES

1.Hurwitz, T, Kopala, L, Clark, C, Jones, B. Olfactory deficits in schizophrenia. Biol Psychiatry. 1988;23:123128.CrossRefGoogle ScholarPubMed
2.Martzke, JS, Kopala, LC, Good, KP. Olfactory dysfunction in neuropsychiatric disorders: review and methodological considerations. Biol Psychiatry. 1997;42:721732.CrossRefGoogle ScholarPubMed
3.Cohen, J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Laurence Erlbaum Associates; 1988.Google Scholar
4.Moberg, PJ, Agrin, R, Gur, RE, et al.Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology. 1999;21:325340.CrossRefGoogle ScholarPubMed
5.Malaspina, D, Wray, AD, Friedman, JH, et al.Odor discrimination deficits in schizophrenia: associations with eye movement dysfunction. J Neuropsychiatry Clin Neurosci. 1994;6:273278.Google ScholarPubMed
6.Clark, C, Kopala, L, Hurwitz, T, Li, D. Regional metabolism in microsmic patients with schizophrenia. Can J Psychiatry. 1991;36:645650.CrossRefGoogle ScholarPubMed
7.Kopala, LC, Clark, C, Hurwitz, TA. Sex differences in olfactory function in schizophrenia. Am J Psychiatry. 1989;146:13201322.Google ScholarPubMed
8.Kopala, LC, Clark, C, Hurwitz, TA. Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophr Res. 1993;8:245250.CrossRefGoogle ScholarPubMed
9.Kopala, L, Good, K, Martzke, J, Hurwitz, T. Olfactory deficits in schizophrenia are not a function of task complexity. Schizophr Res. 1995;17:195199.CrossRefGoogle Scholar
10.Striebel, KM, Beyerstein, B, Remick, RA, Kopala, L, Honer, WG. Olfactory identification and psychosis. Biol Psychiatry. 1999;45:14191425.CrossRefGoogle ScholarPubMed
11.Bradley, EA. Olfactory acuity to a pheromonal substance and psychotic illness. Biol Psychiatry. 1984;19:899905.Google ScholarPubMed
12.Geddes, J, Huws, R, Pratt, P. Olfactory acuity in the positive and negative syndromes of schizophrenia. Biol Psychiatry. 1991;29:774778.CrossRefGoogle ScholarPubMed
13.Gross-Isseroff, R, Stoler, M, Ophir, D, Lancet, D, Sirota, P. Olfactory sensitivity to androstenone in schizophrenic patients. Biol Psychiatry. 1987;22:922925.CrossRefGoogle Scholar
14.Sirota, P, Davidson, B, Mosheva, T, et al.Increased olfactory sensitivity in first episode psychosis and the effect of neuroleptic treatment on olfactory sensitivity in schizophrenia. Psychiatry Res. 1999;86:143153.CrossRefGoogle ScholarPubMed
15.Seidman, LJ, Goldstein, JM, Goodman, JM, et al.Sex differences in olfactory identification and Wisconsin card sorting performance in schizophrenia: relation to attention and verbal ability. Biol Psychiatry. 1997;42:104115.CrossRefGoogle Scholar
16.Brewer, W, Anderson, V, Velakoulis, D, et al.Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis. Amer J Psychiatry. 2001;158:107115.CrossRefGoogle ScholarPubMed
17.Park, S, Schoppe, S. Olfactory identification deficit in relation to schizotypy. Schizophr Res. 1997;26:191197.CrossRefGoogle ScholarPubMed
18.Kopala, L, Good, KP, Torrey-Fuller, E, Honer, WG. Olfactory function in monozygotic twins discordant for schizophrenia. Biol Psychiatry. 1997;42(suppl):194S.CrossRefGoogle Scholar
19.Arnold, SE, Han, LY, Moberg, PJ, et al.Dysregulation of olfactory receptor neuron lineage in schizophrenia. Arch Gen Psychiatry. 2001;58:829835.CrossRefGoogle ScholarPubMed
20.Amsterdam, J, Settle, RG, Doty, RL, Abelman, E, Winokur, A. Taste and smell perception in depression. Biol Psychiatry. 1987;22:14811485.CrossRefGoogle ScholarPubMed
21.Kopala, LC, Good, KP, Honer, WG. Olfactory hallucinations and olfactory identification ability in patients with schizophrenia and other psychiatric disorders. Schizophr Res. 1994;12:205211.CrossRefGoogle ScholarPubMed
22.Oren, DA, Schwartz, PJ, Turner, EH, Rosenthal, NE. Olfactory function in winter seasonal affective disorder. Am J Psychiatry. 1995;152:15311532.Google ScholarPubMed
23.Warner, MD, Peabody, CA, Csernansky, JG. Olfactory functioning in schizophrenia and depression [letter]. Biol Psychiatry. 1990;27:457458.CrossRefGoogle ScholarPubMed
24.Serby, M, Larson, P, Kalkstein, D. Olfactory sense in psychoses [letter]. Biol Psychiatry. 1990;28:829830.CrossRefGoogle ScholarPubMed
25.Fedoroff, IC, Stoner, SA, Anderson, AE, Doty, RL, Rolls, BJ. Olfactory dysfunction in anorexia and bulimia nervosa. Int J Eat Disord. 1995;18:7177.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
26.Kopala, L, Good, K, Goldner, E, Birmingham, C. Olfactory identification ability in anorexia nervosa. J Psychiatry Neurosci. 1995;20:283286.Google ScholarPubMed
27.Kopala, LC, Good, KP. Olfactory identification ability in patients with panic disorder. J Psychiatry Neurosci. 1996;21:340342.Google ScholarPubMed
28.Barnett, R, Maruff, P, Purcell, R, et al.Impairment of olfactory identification in obsessive-compulsive disorder. Psychol Med. 1999;29:12271233.CrossRefGoogle ScholarPubMed
29.Goldberg, ED, Goldberg, R J, Vannoppen, B. Sense of smell and obsessional behavior [letter]. Am J Psychiatry. 1991;148:1757.Google ScholarPubMed
30.Serby, M, Larson, P, Kalkstein, D. The nature and course of olfactory deficits in Alzheimer's disease. Am J Psychiatry. 1991;148:357360.Google ScholarPubMed
31.Stern, MB, Doty, RL, Dotti, M, et al.Olfactory function in Parkinson's disease subtypes. Neurology. 1994;44:266268.CrossRefGoogle ScholarPubMed
32.Bylsma, FW, Moberg, PJ, Doty, RL, Brandt, J. Odor identification in Huntington's disease patients and asymptomatic gene carriers. J Neuropsychiatry Clin Neurosci, 1997;9:598600.Google ScholarPubMed
33.Constantinescu, CS, West, SE, Doty, RL, Raps, EC, Cohen, JA. Olfactory disturbance as the initial or most prominent symptom of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1994;57:10111062.CrossRefGoogle ScholarPubMed
34.Hawkes, CH, Shephard, BC. Olfactory evoked responses and identification tests in neurological disease. Ann N Y Acad Sci. 1998;855:608624.CrossRefGoogle ScholarPubMed
35.Mair, RC, Doty, RL, Kelly, KM, et al.Multimodal sensory discrimination deficits in Korsakoff's psychosis. Neuropsychologia. 1986;24:831839.CrossRefGoogle ScholarPubMed
36.Warner, MD, Peabody, CA, Berger, PA. Olfactory deficits and Down syndrome. Biol Psychiatry. 1988;23:833836.CrossRefGoogle Scholar
37.Savic, I, Bookheimer, S, Fried, I, Engel, J. Olfactory bedside test: a simple approach to identify temporo-orbitofrontal dysfunction. Arch Neurol. 1997;54:162168.CrossRefGoogle ScholarPubMed
38.Mesholam, RI, Moberg, PJ, Mahr, RN, Doty, RL. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol. 1998;55:8490.CrossRefGoogle ScholarPubMed
39.Doty, RL, Applebaum, S, Zusho, H, Settle, RG. Sex differences in odor identification ability: a cross-cultural study analysis. Neuropsychologia. 1985;23:667672.CrossRefGoogle Scholar
40.Doty, RL, Shaman, P, Applebaum, SL, et al.Smell identification ability: changes with age. Science. 1984;226:14411443.CrossRefGoogle ScholarPubMed
41.Frye, R, Schwartz, B. Dose-related effects of cigarette smoking on olfactory function. JAMA. 1990;263:12331236.CrossRefGoogle ScholarPubMed
42.Jones, RE, Brown, CC, Ship, JA. Odor identification in young and elderly African-Americans and Caucasians. Spec Care Dentist. 1995;15:138143.CrossRefGoogle Scholar
43.Ship, JA, Weiffenbach, JM. Age, gender, medical treatment, and medication effects on smell identification. J Gerontol. 1993;48:M26M32.CrossRefGoogle ScholarPubMed
44.Kopala, LC, Good, K, Honer, WG. Olfactory identification ability in pre- and postmenopausal women with schizophrenia. Biol Psychiatry. 1995;38:5763.CrossRefGoogle ScholarPubMed
45.Houlihan, DJ, Flaum, M, Arnold, SE, Keshavan, M, Alliger, R. Further evidence for olfactory identification deficits in schizophrenia. Schizophr Res. 1994;12:179182.CrossRefGoogle ScholarPubMed
46.Moberg, PJ, Doty, R, Turetsky, B, et al.Olfactory identification deficits in schizophrenia: correlation with duration of illness. Am J Psychiatry. 1997;7:10161018.Google Scholar
47.Malaspina, D, Perera, GM, Lignelli, A, et al.SPECT imaging of odor identification in schizophrenia. Psychiatry Res. 1998;82:5361.CrossRefGoogle ScholarPubMed
48.Seidman, LJ, Osear-Berman, M, Kalinowski, AG, et al.Experimental and clinical neuropsychological measures of prefrontal dysfunction in schizophrenia. Neuropsychology. 1995;9:481490.CrossRefGoogle Scholar
49.Brewer, WJ, Edwards, J, Anderson, V, Robinson, T, Pantelis, C. Neuropsychological, olfactory and hygiene deficits in men with negative symptom schizophrenia. Biol Psychiatry. 1996;40:10211031.CrossRefGoogle ScholarPubMed
50.Kopala, LC, Good, KP, Koczapski, AB, Honer, WG. Olfactory deficits in patients with schizophrenia and severe polydipsia. Biol Psychiatry. 1998;43:497502.CrossRefGoogle ScholarPubMed
51.Seidman, LJ, Talbot, NL, Kalinowski, AG, et al.Neuropsychological probes of fron-to-limbic system dysfunction in schizophrenia: olfactory identification and Wisconsin Card Sorting performance. Schizophr Res. 1992;6:5565.CrossRefGoogle Scholar
52.Nurnberger, JI, Blehar, MC, Kaufmann, CA, et al.Diagnostic interview for genetic studies: rationale, unique features, and training: NIMH genetics initiative. Arch Gen Psychiatry. 1994;51:849859.CrossRefGoogle ScholarPubMed
53.Hollingshead, AB. Four Factor Index of Social Status. New Haven, Conn: Yale University Press; 1975.Google Scholar
54.Doty, RL, Shaman, P, Dann, M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function [monograph]. Physiol Behav. 1984;32:489502.CrossRefGoogle Scholar