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Obsessive-Compulsive Disorder: An Open-Label Pilot Trial of Escitalopram

Published online by Cambridge University Press:  07 November 2014

Amanda Galvão-de Almeida ,
Lucas C. Quarantini ,
Cristianne R. Góis ,
Rogério Santos-Jesus ,
Ângela M.A. Miranda-Scippa ,
Irismar R. de Oliveira ,
Helena da Silva Prado ,
James F. Leckman  and
Maria C. Rosário
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Abstract

Introduction: Selective serotonin reuptake inhibitors are considered the most effective and well-established pharmacotherapy for the treatment of obsessive-compulsive disorder (OCD), a chronic and disabling condition. However, ~40% of patients do not have a significant improvement, suggesting that new medications are needed. This study was designed to investigate the treatment response to escitalopram in OCD patients.

Methods: This open-label study involved 11 adult OCD outpatients diagnosed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders. Data were collected and the treatment response was assessed by an experienced psychiatrist by using the Yale-Brown Obsessive-Compulsive Scale. Subjects received escitalopram 30 mg/day for 12 weeks starting at 10 mg/day. Dosage adjustments were made within 2 weeks, depending on the tolerability of the patient.

Results: Six of the 11 patients (54.5%) presented a reduction of at least 40% in the baseline total Yale-Brown Obsessive-Compulsive Scale scores.

Conclusion: Despite the small sample size and the open-label nature of this trial, these data suggest that escitalopram may be a useful option for patients with OCD.

Type
Original Research
Information
CNS Spectrums , Volume 12 , Issue 7 , July 2007 , pp. 519 - 524
Copyright
Copyright © Cambridge University Press 2007

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