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Long-acting injectable antipsychotics: shall the last be first?

Published online by Cambridge University Press:  11 February 2014

Abstract

ISSUE:A paradigm shift is afoot in which the “last shall be first,” namely, use of long-acting injectable (LAI) antipsychotics, rather than being reserved for use only at the last stages of schizophrenia, may be shifting to first-line treatment of early episodes of this illness.

Type
Brainstorms
Copyright
Copyright © Cambridge University Press 2014 

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References

1. Stahl, SM. Stahl's Essential Psychopharmacology: The Prescriber's Guide, 5th ed. Cambridge, UK: Cambridge University Press; 2014.Google Scholar
2. Citrome, L. New second-generation long-acting injectable antipsychotics for the treatment of schizophrenia. Expert Rev Neurother. 2013; 13(7): 767783.Google Scholar
3. Lacro, JP, Dunn, LB, Dolder, CR, Leckband, SG, Jeste, DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry. 2002; 63(10): 892909.Google Scholar
4. Shi, L, Ascher-Svanum, H, Zhu, B, etal. Characteristics and use patterns of patients taking first generation depot antipsychotics or oral antipsychotics for schizophrenia. Psychiatr Serv. 2007; 58(4): 482488.Google Scholar
5. Munk-Jorgensen, P, Nielsen, J, Nielsen, RE, Stahl, SM. Last episode psychosis. Acta Psychiatr Scand. 2009; 119(6): 417418.CrossRefGoogle ScholarPubMed
6. Morrisette, DA, Stahl, SM. Optimizing outcomes in schizophrenia: long acting depots and long term treatment. CNS Spectr. 2012; 17(Suppl 1): 1021.Google Scholar
7. Morrissette, DA, Stahl, SM. Should high dose or very long-term antipsychotic monotherapy be considered before antipsychotic polypharmacy? In: Ritsner MS, ed. Polypharmacy in Psychiatric Practice. Dordrecht, NL: Springer. Vol. I; 2012: 107125.Google Scholar
8. van Haren, NE, Hulshoff Pol, HE, Schnack, HG, etal. Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study. Neuropsychopharmacology. 2007; 32(10): 20572066.Google Scholar
9. Stahl, SM. Stahl;s Essential Psychopharmacology, 4th ed. Cambridge, UK: Cambridge University Press; 2013.Google Scholar
10. Agid, O, Arenovich, T, Sajeev, G, etal. An algorithm-based approach to first episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis. J Clin Psychiatry. 2011; 72(11): 14391444.CrossRefGoogle ScholarPubMed
11. Kishimoto, T, Nitta, M, Borenstein, M, Kane, JM, Correll, CU. Long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis of mirror-image studies. J Clin Psychiatry. 2013; 74(10): 957965.Google Scholar
12. Tiihonen, J, Haukka, J, Taylor, M, etal. A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia. Am J Psychiatry. 2011; 168(6): 603609.Google Scholar
13. Rosenheck, RA, Krystal, JH, Lew, R, etal. Long-acting risperidone and oral antipsychotics in unstable schizophrenia. New Engl J Med. 2011; 364(9): 842851.Google Scholar
14. Subotnik, KL, Nuechterlein, KH, Ventura, J, etal. Risperidone nonadherence and return of positive symptoms in the early course of schizophrenia. Am J Psychiatry. 2011; 168(3): 286292.Google Scholar