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Formal Thought Disorder and Semantic Memory in Schizophrenia

Published online by Cambridge University Press:  07 November 2014

Abstract

In this article, we review attempts to account for the thought disorder present in some schizophrenic patients in terms of cognitive deficits in the domains of working memory, attention, language, and semantic memory. Although each psychological construct can account for some of the data described here, establishment of a primary cognitive impairment responsible for thought disorder is not forthcoming, perhaps due to its underlying multidimensional pathology. While the relationship of working memory, attention, and language processing to thought disorder is ambiguous, semantic memory is emerging as a promising construct, that may yield insight into cognitive mechanisms that underlie thought disorder and neuroleptic responsiveness.

Type
Feature Article
Copyright
Copyright © Cambridge University Press 1997

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References

1.Liddle, PF. The symptoms of chronic schizophrenia: a reexamination of the positive-negative dichotomy. Br J Psychiatry. 1987;151:145151.Google Scholar
2.Liddle, PF, Barnes, TRE. Syndromes of chronic schizophrenia. Br J Psychiatry. 1990;157:558561.CrossRefGoogle ScholarPubMed
3.Liddle, PF, Morris, DL. Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry. 1991;158:340345.Google Scholar
4.Bilder, RM, Mukherjee, S, Rieder, RO, Pandurangi, AK. Symptomatic and neuropsychological components of defect states. Schizophr Bull. 1985;11:409419.Google Scholar
5.Harrow, M, Grossman, LS, Silverstein, ML, Meltzer, HY. Thought pathology in manic and schizophrenic patients: its occurrence at hospital admission and seven weeks later. Arch Gen Psychiatry. 1982;39:665671.CrossRefGoogle ScholarPubMed
6.Goldman-Rakic, PS. Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci. 1988;11:137156.Google Scholar
7.Freedman, M, Oscar-Berman, M. Bilateral frontal disease and selective delayed response deficits in humans. Behav Neurosci. 1986; 100:337342.CrossRefGoogle ScholarPubMed
8.Hoffman, RE. Verbal hallucinations and language production processes in schizophrenia. Behavioral and Brain Sciences. 1986;9:503548.Google Scholar
9.McGrath, J. Ordering thoughts on thought disorder. Br J Psychiatry. 1991;158:307316.Google Scholar
10.Cleghorn, JM, Kaplan, RD, Szechtman, B, Szechtman, H, Brown, GM. Neuroleptic drug effects on cognitive function in schizophrenia. Schizophr Res. 1990;3:211219.Google Scholar
11.Seidman, LJ, Pepple, JR, Faraone, SV, et al.Neuropsychological performance in chronic schizophrenia in response to neuroleptic dose reduction. Biol Psychiatry. 1993;33:575584.Google Scholar
12.Hurt, SW, Holzman, PS, Davis, JM. Thought disorder: the measurement of its change. Arch Gen Psychiatry. 1983;40:12811285.Google Scholar
13.Bigelow, LB, Berthot, BD. The psychiatric symptom assessment scale (PSAS). Psychopharmacol Bull. 1989;25:168179.Google Scholar
14.Harvey, PD, Earle-Boyer, E, Levinson, JC. Distractibility and discourse failure: their association in mania and schizophrenia. J Nerv Ment Dis. 1986;174:274279.CrossRefGoogle ScholarPubMed
15.Hotchkiss, AP, Harvey, PD. Effect of distraction on communication failures in schizophrenic patients. Am J Psychiatry. 1990;147:513515.Google ScholarPubMed
16.Nuechterlein, KH, Edell, WS, Norris, M, Dawson, ME. Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophr Bull. 1986;12:408426.Google Scholar
17.Johnston, MH, Holzman, PS. Assessing Schizophrenic Thinking: A Clinical and Research Instrument for Measuring Thought Disorder. San Francisco, Calif: Jossey-Bass; 1979.Google Scholar
18.Cornblatt, BA, Keilp, JG. Impaired attention, genetics, and the psychophysiology of schizophrenia. Schizophr Bull. 1994;20:3146.Google Scholar
19.Servan-Schreiber, D, Cohen, JD, Steingard, S. Schizophrenic deficits in the processing of context: a test of a theoretical model. Arch Gen Psychiatry. 1996;53:11051112.Google Scholar
20.Morice, R, Ingram, JCL. Language analysis in schizophrenia: diagnostic implications. Aust N Z J Psychiatry. 1982;16:1121.Google Scholar
21.Fraser, WI, King, KM, Thomas, P, Kendell, RE. The diagnosis of schizophrenia by language analysis. Br J Psychiatry. 1986;148:275278.Google Scholar
22.King, K, Fraser, WI, Thomas, P, Kendell, RE. Re-examination of the language of psychotic subjects. Br J Psychiatry. 1990;156:211215.Google Scholar
23.Faber, R, Reichstein, MB. Language dysfunction in schizophrenia. Br J Psychiatry. 1981;139:519522.Google Scholar
24.Anand, A, Wales, RJ, Jackson, HJ, Copolov, DL. Linguistic impairment in early psychosis. J Nerv Ment Dis. 1994;182:488493.Google Scholar
25.Allen, HA, Allen, DS. Positive symptoms and the organization within and between ideas in schizophrenic speech. Psychol Med. 1985;15:7180.Google Scholar
26.Tulving, E. Episodic and semantic memory. In: Tulving, E, Donaldson, W, eds. Organisation of Memory. London: Academic Press; 1972.Google Scholar
27.Cutting, J, Murphy, D. Schizophrenic thought disorder: a psychological and organic interpretation. Br J Psychiatry. 1988;152:310319.Google Scholar
28.Frith, CD. The Cognitive Neuropsychology of Schizophrenia. Hillsdale, NJ: Lawrence Erlbaum Associates; 1992:113134.Google Scholar
29.Tamlyn, D, McKenna, PJ, Mortimer, AM, Lund, CE, Hammond, S, Baddeley, AD. Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character. Psychol Med. 1992;22:101115.Google Scholar
30.McKenna, PJ, Mortimer, AM, Hodges, JR. Semantic memory and schizophrenia. In: David, AS, Cutting, JC, eds. The Neuropsychology of Schizophrenia. Hillsdale, NJ: Lawrence Erlbaum Associates; 1994:163178.Google Scholar
31.Hodges, JR, Salmon, DP, Butters, N. Semantic memory impairment in Alzheimer's disease: failure of access or degraded knowledge? Neuropsychologia. 1992;30:301314.Google Scholar
32.Chen, EYH, Wilkins, AJ, McKenna, PJ. Semantic memory is both impaired and anomalous in schizophrenia. Psychol Med. 1994;24:193202.Google Scholar
33.Metzger, RL, Miller, ML, Cohen, M, Sofka, M, Borkovec, TD. Worry changes decision making: the effects of negative thoughts on cognitive processing. J Clin Psychol. 1990;46:7888.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
34.Collins, AM, Quillian, MR. Retrieval time from semantic memory. Journal of Verbal Learning and Verbal Behavior. 1969;8:240247.CrossRefGoogle Scholar
35.Manschreck, TC, Maher, BA, Milavetz, JJ, Ames, D, Weisstein, CC, Schneyer, ML. Semantic priming in thought disordered schizophrenic patients. Schizophr Res. 1988;1:6166.Google Scholar
36.Spitzer, M, Weisker, I, Winter, M, Maier, S, Hermle, L, Maher, BA. Semantic and phonological priming in schizophrenia. J Abnorm Psychol. 1994;103:485494.Google Scholar
37.Vinogradov, S, Ober, BA, Shenaut, GK. Semantic priming of word pronunciation and lexical decision in schizophrenia. Schizophr Res. 1992;8:171181.CrossRefGoogle ScholarPubMed
38.Goldberg, TE, Weinberger, DR. Thought disorder, working memory and attention: interrelationships and the effects of neuroleptic medications. Int Clin Psychopharmacol. 1995;10(suppl 3):99104.Google Scholar
39.Ober, BA, Vinogradov, S, Shenaut, GK. Semantic priming of category relations in schizophrenia. Neuropsychology. 1995;9:220228.Google Scholar
40.Gourovitch, ML, Goldberg, TE, Weinberger, DR. Verbal fluency deficits in patients with schizophrenia: semantic fluency is differentially impaired as compared to phonologic fluency. Neuropsychology. 1996;10:573577.CrossRefGoogle Scholar
41.Randolph, C, Braun, A, Goldberg, TE, Chase, TN. Semantic fluency in Alzheimer's, Parkinson's, and Huntington's disease: dissociation of storage and retrieval failures. Neuropsychology. 1993;7:17.CrossRefGoogle Scholar
42.Joyce, EM, Collinson, SL, Crichton, P. Verbal fluency in schizophrenia: relationship with executive function, semantic memory and clinical alogia. Psychol Med. 1996;26:3949.Google Scholar
43.Aloia, MS, Gourovitch, ML, Weinberger, DR, Goldberg, TE. An investigation of semantic space in patients with schizophrenia. J Int Neuropsychol Soc. 1996;2:267273.CrossRefGoogle ScholarPubMed
44.Kutas, M, Hillyard, SA. Contextual effects in language comprehension: studies using event-related brain potentials. In: Plum, F, ed. Language, Communication and the Brain. New York, NY: Raven Press; 1988:87100.Google Scholar
45.Curran, T, Tucker, DM, Kutas, M, Posner, MI. Topography of the N400: brain electrical activity reflecting semantic expectancy. Electroencephalogr Clin Neurophysiol. 1993;88:188209.Google Scholar
46.Kutas, M, Hillyard, SA. Brain potentials during reading reflect word expectancy and semantic association. Nature. 1984;307:161163.CrossRefGoogle ScholarPubMed
47.Andrews, S, Shelley, A-M, Ward, PB, Fox, A, Catts, SV, McConaghy, N. Event-related potential indices of semantic processing in schizophrenia. Biol Psychiatry. 1993;34:443458.Google Scholar
48.Grillon, C, Ameli, R, Glazer, WM. N400 and semantic categorization in schizophrenia. Biol Psychiatry. 1991;29:467480.Google Scholar
49.Adams, J, Faux, SF, Nestor, PG, et al.ERP abnormalities during semantic processing in schizophrenia. Schizophr Res. 1993;10:247257.CrossRefGoogle ScholarPubMed
50.Skimkunas, AM, Gynther, MD, Smith, K. Schizophrenic response to the proverbs test: abstract, concrete, or autistic? J Abnorm Psychol. 1967;72:128133.Google Scholar
51.Bigelow, LB, Donnelly, EP, Torrey, EF, Lee, CA. Assessment of clinical status of schizophrenic patients by the WAIS comprehension subtest. J Clin Psychiatry. 1979;40:258261.Google Scholar
52.Spohn, HE, Coyne, L, Larson, J, Mittleman, F, Spray, J, Hayes, K. Episodic and residual thought pathology in chronic schizophrenics: effect of neuroleptics. Schizophr Bull. 1986;12:394407.Google Scholar
53.Goldberg, TE, Greenberg, RD, Griffin, SJ, et al.The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br J Psychiatry. 1993;162:4348.Google Scholar