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Disturbances of phosphatidylcholines metabolism in major depressive disorder

Published online by Cambridge University Press:  17 January 2023

Yue Wang ,
Xiangyu Chen ,
Zhi Chen ,
Heming Yu ,
Yu Tian ,
Yong He ,
Ke Cheng  and
Peng Xie Open the ORCID record for Peng Xie [Opens in a new window]
Yue Wang
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Xiangyu Chen
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Zhi Chen
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Heming Yu
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Yu Tian
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Yong He
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Ke Cheng*
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China
Peng Xie*
Affiliation:
NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Neurobiology, Chongqing, China Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
*
*Authors for correspondence: Ke Cheng and Peng Xie, Emails: jackchengke@163.com; xiepeng@cqmu.edu.cn
*Authors for correspondence: Ke Cheng and Peng Xie, Emails: jackchengke@163.com; xiepeng@cqmu.edu.cn
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Abstract

Objective

Major depressive disorder (MDD) is a common neuropsychiatry disorder with high prevalence and recurrence rate, but the misdiagnosis rate is inevitable due to the shortage of objective laboratory-based diagnostic criteria. This study is focused on the disturbance of lipid metabolism, providing potential biomarkers for diagnosing.

Methods

Lipid metabolism-related molecules in plasma of 42 drug-naïve MDD patients and 49 healthy people were measured by liquid chromatography-mass spectrometry. Further to evaluate the diagnostic values of changed metabolites, these molecules were evaluated by the receiver operating characteristic curve. Based on the significant role of phosphatidylcholine (PC) disturbance in depression, oxidization of PCs, oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC), IL-8 and caspase-3 in hippocampus, and serum of chronic lipopolysaccharide (cLPS) depression mice were detected by ELISA.

Results

Compared with healthy control, MDD patients expressed higher 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (16:0-16:0 PC, DPPC), 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (16:0-20:4 PC, PAPC), 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine (16:0-18:0 PC), glycocholic acid, taurocholic acid, glycoursodeoxycholic acid, and chenodeoxycholic acid glycine conjugate, and lower 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC 20:0). The 16:0-20:4 PC showed the great diagnostic value for MDD with an area under the curve (AUC) of 0.9519, and combination of 16:0 PC, 16:0-18:0 PC, and 16:0-20:4 PC exhibited the highest diagnostic value with AUC of 0.9602. OxPAPC was certified increase in hippocampus and serum of cLPS depression mice, which further supported PCs disorder participated in depression.

Conclusion

This research offers 16:0-20:4 PC as the latent diagnostic indicator for MDD and hints the important role of PCs in depression.

Keywords

Major depressive disorderphosphatidylcholines metabolismPAPCOxPAPCcLPS
Type
Original Research
Information
CNS Spectrums , Volume 28 , Issue 5 , October 2023 , pp. 637 - 645
Copyright
© The Author(s), 2023. Published by Cambridge University Press

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Footnotes

Y.W. and X.C. contributed equally.

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