Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-23T08:36:10.070Z Has data issue: false hasContentIssue false
  • English
  • Français

Bipolar Spectrum disorders in Parkinson’s disease: a systematic evaluation

Published online by Cambridge University Press:  07 December 2020

Silvia Bacciardi ,
Camilla Elefante Open the ORCID record for Camilla Elefante [Opens in a new window] ,
Giulio Emilio Brancati ,
Sonia Mazzucchi ,
Eleonora Del Prete ,
Daniela Frosini ,
Icro Maremmani ,
Lorenzo Lattanzi ,
Roberto Ceravolo  and
Ubaldo Bonuccelli
...Show all authors
Silvia Bacciardi
Affiliation:
North-Western Tuscany Local Health Unit, Department of Psychiatry, Tuscany NHS, Viareggio, Italy Pisa-School of Clinical and Experimental Psychiatry, Institute for Improving Neuroscientific Knowledge, Pisa, Italy
Camilla Elefante
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy
Giulio Emilio Brancati
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy
Sonia Mazzucchi
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Eleonora Del Prete
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Daniela Frosini
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Icro Maremmani
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy Association for the Application of Neuroscientific Knowledge to Social Aims (AU-CNS), Lucca, Italy G. De Lisio Institute of Behavioral Sciences, Pisa, Italy
Lorenzo Lattanzi
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy
Roberto Ceravolo
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Ubaldo Bonuccelli
Affiliation:
Department of Clinical and Experimental Medicine—Neurology Unit, University of Pisa, Pisa, Italy
Giulio Perugi*
Affiliation:
Department of Clinical and Experimental Medicine—Psychiatry Unit, University of Pisa, Pisa, Italy G. De Lisio Institute of Behavioral Sciences, Pisa, Italy
*
*Author for correspondence: Giulio Perugi, Email: giulio.perugi@med.unipi.it
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Psychiatric disorders are very common in patients affected by Parkinson’s disease (PD). However, comorbidity with Bipolar Spectrum disorders is understudied. The aim of this study is to explore the clinical correlates of PD associated with Bipolar Spectrum disorders.

Methods

One hundred PD patients were screened for psychiatric comorbidities, cognitive profile, motor, and non-motor symptoms. The sample was divided into three groups: PD-patients with Bipolar Spectrum disorders (bipolar disorder type I, type II, and spontaneous or induced hypomania; N = 32), PD-patients with others psychiatric comorbidities (N = 39), PD-patients without psychiatric comorbidities (N = 29). Clinical features were compared among the groups using analysis of variance and chi-square test. A logistic regression was performed to evaluate the association between Bipolar Spectrum disorders and early onset of PD (≤50 years) controlling for lifetime antipsychotic use.

Results

In comparison with PD patients with and without other psychiatric comorbidity, subjects affected by Bipolar Spectrum disorders were younger, showed more frequently an early onset PD, reported more involuntary movements and a higher rate of impulse control disorders and compulsive behaviors. No differences were observed in indexes of exposure to dopamine agonist treatments. The early onset of PD was predicted by Bipolar Spectrum comorbidity, independently from lifetime antipsychotic use.

Conclusion

Bipolar Spectrum disorders are common in early onset PD. The presence of bipolar comorbidity could identify a particular subtype of PD, showing higher rates of neurological and psychiatric complications and deserving further investigation.

Keywords

Parkinson’s DiseaseBipolar DisorderComorbidity
Type
Original Research
Information
CNS Spectrums , Volume 27 , Issue 3 , June 2022 , pp. 355 - 361
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Parent, M, Parent, A. Substantia nigra and Parkinson’s disease: a brief history of their long and intimate relationship. Can J Neurol Sci J Can Sci Neurol. 2010;37(3):313–319.CrossRefGoogle ScholarPubMed
Ulla, M, Thobois, S, Lemaire, J, et al. Manic behaviour induced by deep-brain stimulation in Parkinson’s disease: evidence of substantia nigra implication? J Neurol Neurosurg Psychiatry. 2006;77(12):1363–1366. doi:10.1136/jnnp.2006.096628.CrossRefGoogle ScholarPubMed
Doshi, PK. Mania induced by stimulation following DBS of the bed nucleus of stria terminalis for obsessive-compulsive disorder. Stereotact Funct Neurosurg. 2016;94(5):326. doi:10.1159/000449066.CrossRefGoogle ScholarPubMed
Voon, V, Saint-Cyr, J, Lozano, AM, et al. Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgery. J Neurosurg. 2005;103(2):246–251. doi:10.3171/jns.2005.103.2.0246.CrossRefGoogle ScholarPubMed
Maier, F, Merkl, J, Ellereit, AL, et al. Hypomania and mania related to dopamine replacement therapy in Parkinson’s disease. Park Relat Disord. 2014;20:421–427. doi:10.1016/j.parkreldis.2014.01.001.CrossRefGoogle ScholarPubMed
Perugi, G, De Rossi, P, Fagiolini, A, et al. Personalized and precision medicine as informants for treatment management of bipolar disorder. Int Clin Psychopharmacol. 2019;34(4):189–205. doi:10.1097/YIC.0000000000000260.CrossRefGoogle ScholarPubMed
Buoli, M, Serati, M, Caldiroli, A, et al. Neurodevelopmental versus neurodegenerative model of schizophrenia and bipolar disorder: comparison with physiological brain development and aging. Psychiatr Danub. 2017;29(1):24–27.CrossRefGoogle ScholarPubMed
Ng, B, Camacho, A, Lara, DR, et al. A case series on the hypothesized connection between dementia and bipolar spectrum disorders: bipolar type VI? J Affect Disord. 2008;107(1–3):307–315. doi:10.1016/j.jad.2007.08.018.CrossRefGoogle ScholarPubMed
Van Gerpen, MW, Johnson, JE, Winstead, DK. Mania in the geriatric patient population: a review of the literature. Am J Geriatr Psychiatry Off J Am Assoc Geriatr Psychiatry. 1999;7(3):188–202.CrossRefGoogle ScholarPubMed
Fujikawa, T, Yamawaki, S, Touhouda, Y. Silent cerebral infarctions in patients with late-onset mania. Stroke. 1995;26(6):946–949.CrossRefGoogle ScholarPubMed
Robinson, RG, Boston, JD, Starkstein, SE, Price, TR. Comparison of mania and depression after brain injury: causal factors. Am J Psychiatry. 1988;145(2):172–178. doi:10.1176/ajp.145.2.172.Google ScholarPubMed
Zarowitz, BJ, O’Shea, T, Nance, M. Clinical, demographic, and pharmacologic features of nursing home residents with Huntington’s disease. J Am Med Dir Assoc. 2014;15(6):423–428. doi:10.1016/j.jamda.2014.01.010.CrossRefGoogle ScholarPubMed
Bertram, L, Tanzi, RE. The genetic epidemiology of neurodegenerative disease. J Clin Invest. 2005;115(6):1449–1457. doi:10.1172/JCI24761.CrossRefGoogle ScholarPubMed
da Silva, J, Gonçalves-Pereira, M, Xavier, M, Mukaetova-Ladinska, EB. Affective disorders and risk of developing dementia: systematic review. Br J Psychiatry. 2013;202(3):177–186. doi:10.1192/bjp.bp.111.101931.CrossRefGoogle ScholarPubMed
Byers, AL, Yaffe, K. Depression and risk of developing dementia. Nat Rev Neurol. 2011;7(6):323–331. doi:10.1038/nrneurol.2011.60.CrossRefGoogle ScholarPubMed
Corrêa-Velloso, JC, Gonçalves, MC, Naaldijk, Y, Oliveira-Giacomelli, Á, et al. Pathophysiology in the comorbidity of bipolar disorder and Alzheimer’s disease: pharmacological and stem cell approaches. Prog Neuropsychopharmacol Biol Psychiatry. 2018;80(Pt A):34–53. doi:10.1016/j.pnpbp.2017.04.033.CrossRefGoogle ScholarPubMed
Postuma, RB, Berg, D, Stern, M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord Off J Mov Disord Soc. 2015;30(12):1591–1601. doi:10.1002/mds.26424.CrossRefGoogle ScholarPubMed
Himmelhoch, Jonathan M. Relationship of bipolar depression to involuntary motor disorders. In: Bipolar Disorders: Basic Mechanisms and Therapeutic Implications. New York: Marcel Dekker, Inc.;2000. pp. 317–342.Google Scholar
Starkstein, SE, Fedoroff, P, Berthier, ML, Robinson, RG. Manic-depressive and pure manic states after brain lesions. Biol Psychiatry. 1991;29(2):149–158.CrossRefGoogle ScholarPubMed
Berk, M, Dodd, S, Kauer-Sant’anna, M, et al. Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatr Scand Suppl. 2007:41–49. doi:10.1111/j.1600-0447.2007.01058.x.CrossRefGoogle ScholarPubMed
Nilsson, FM, Kessing, LV, Bolwig, TG. Increased risk of developing Parkinson’s disease for patients with major affective disorder: a register study. Acta Psychiatr Scand. 2001;104:380–386.CrossRefGoogle ScholarPubMed
Kummer, A, Dias, FM, Cardoso, F, Teixeira, AL. Low frequency of bipolar disorder, dopamine dysregulation syndrome, and punding in Brazilian patients with Parkinson’s disease. Rev Bras Psiquiatr. 2010;32:62–65.CrossRefGoogle ScholarPubMed
Kilbourne, AM, Cornelius, JR, Han, X, et al. Burden of general medical conditions among individuals with bipolar disorder. Bipolar Disord. 2004;6:368–373.CrossRefGoogle ScholarPubMed
Kim, E, Zwil, AS, McAllister, TW, Glosser, DS, Stern, M, Hurtig, H. Treatment of organic bipolar mood disorders in Parkinson’s disease. J Neuropsychiatry Clin Neurosci. 1994;6:181–184. doi:10.1176/jnp.6.2.181.Google ScholarPubMed
Engmann, B. Bipolar affective disorder and Parkinson’s disease. Case Rep Med. 2011;2011:154165. doi:10.1155/2011/154165.CrossRefGoogle ScholarPubMed
Lin, HL, Lin, HC, Chen, YH. Psychiatric diseases predated the occurrence of Parkinson disease: a retrospective cohort study. Ann Epidemiol. 2014;24:206–213.CrossRefGoogle ScholarPubMed
Faustino, PR, Duarte, GS, Chendo, I et al. Risk of developing Parkinson disease in bipolar disorder: a systematic review and meta-analysis. JAMA Neurol. 2019;77:192–198. doi:10.1001/jamaneurol.2019.3446.CrossRefGoogle Scholar
Huang, MH, Cheng, CM, Huang, KL, et al. Bipolar disorder and risk of Parkinson disease: a nationwide longitudinal study. Neurology. 2019;92(24):e2735–e2742. doi:10.1212/WNL.0000000000007649 CrossRefGoogle ScholarPubMed
Postuma, RB, Berg, D, Stern, M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord Off J Mov Disord Soc. 2015;30(12):1591–1601. doi:10.1002/mds.26424.CrossRefGoogle ScholarPubMed
Gelb, DJ, Oliver, E, Gilman, S. Diagnostic criteria for Parkinson disease. Arch Neurol. 1999;56(1):33–39. doi:10.1001/archneur.56.1.33.CrossRefGoogle ScholarPubMed
Fahn, S, Elton, RL. UPDRS Development Committee. The Unified Parkinson’s Disease Rating Scale. In: Fahn, S, Marsden, CD, Calne, DB, Goldstein, M, editors. Recent Developments in Parkinson’s Disease. 2nd edn Macmillan Healthcare Information; Florham Park, NJ: 1987. pp. 153–163. pp. 293–304.Google Scholar
Folstein, MF, Folstein, SE, McHugh, PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198.CrossRefGoogle ScholarPubMed
Schrag, A, Schott, JM. Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism. Lancet Neurol. 2006;5(4):355–363. doi:10.1016/S1474-4422(06)70411-2.CrossRefGoogle ScholarPubMed
Gibb, WR, Lees, AJ. A comparison of clinical and pathological features of young- and old-onset Parkinson’s disease. Neurology. 1988;38(9):1402–1406. doi:10.1212/wnl.38.9.1402.CrossRefGoogle Scholar
Golbe, LI. Young-onset Parkinson’s disease: a clinical review. Neurology. 1991;41(2[Pt 1]):168–173. doi:10.1212/wnl.41.2_part_1.168.CrossRefGoogle ScholarPubMed
Sheehan, DV, Lecrubier, Y, Sheehan, KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 (Suppl 20):22–33;quiz 34–57.Google ScholarPubMed
American Psychiatric Association. Diagnositic and Statistical Manual of Mental Disorders. 4th ed. Text-Revised: DSM-IV-TR. Washington, DC: American Psychiatric Publishing, Inc; 2000.Google Scholar
Cassano, GB, Akiskal, HS, Musetti, L, et al. Psychopathology, temperament, and past course in primary major depressions. 2. Toward a redefinition of bipolarity with a new semistructured interview for depression. Psychopathology. 1989;22(5):278–288. doi:10.1159/000284608.CrossRefGoogle Scholar
Perugi, G, Quaranta, G, Belletti, S, et al. General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. J Affect Disord. 2015;170:95–103. doi:10.1016/j.jad.2014.08.052.CrossRefGoogle ScholarPubMed
Weintraub, D, Claassen, DO. Impulse control and related disorders in Parkinson’s disease. Int Rev Neurobiol. 2017;133:679–717. doi:10.1016/bs.irn.2017.04.006.CrossRefGoogle ScholarPubMed
Roncone, R, Ventura, J, Impallomeni, M, et al. Reliability of an Italian standardized and expanded Brief Psychiatric Rating Scale (BPRS 4.0) in raters with high vs. low clinical experience. Acta Psychiatr Scand. 1999;100(3):229–236.CrossRefGoogle ScholarPubMed
Erfurth, A, Gerlach, AL, Hellweg, I, et al. Studies on a German (Münster) version of the temperament auto-questionnaire TEMPS-A: construction and validation of the brief TEMPS-M. J Affect Disord. 2005;85(1–2):53–69. doi:10.1016/S0165-0327(03)00102-2.CrossRefGoogle Scholar
Chaudhuri, KR, Martinez-Martin, P, Schapira, AHV, et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord Off J Mov Disord Soc. 2006;21(7):916–923. doi:10.1002/mds.20844.CrossRefGoogle ScholarPubMed
Visser, M, Verbaan, D, van Rooden, SM, et al. Assessment of psychiatric complications in Parkinson’s disease: the SCOPA-PC. Mov Disord Off J Mov Disord Soc. 2007;22(15):2221–2228. doi:10.1002/mds.21696.CrossRefGoogle ScholarPubMed
Sockeel, P, Dujardin, K, Devos, D, et al. The Lille Apathy Rating Scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2006;77(5):579–584. doi:10.1136/jnnp.2005.075929.CrossRefGoogle ScholarPubMed
Weintraub, D, Burn, DJ. Parkinson’s disease: the quintessential neuropsychiatric disorder. Mov Disord. 2011;26:1022–1031.CrossRefGoogle ScholarPubMed
Reijnders, JSAM, Ehrt, U, Weber, WEJ, et al. A systematic review of prevalence studies of depression in Parkinson’s disease. Mov Disord Off J Mov Disord Soc. 2008;23(2):183–189; quiz 313. doi:10.1002/mds.21803.CrossRefGoogle ScholarPubMed
McElroy, SL, Hudson, JI, Pope, HG, et al. The DSM-III-R impulse control disorders not elsewhere classified: clinical characteristics and relationship to other psychiatric disorders. Am J Psychiatry. 1992;149(3):318–327. doi:10.1176/ajp.149.3.318.Google Scholar
Voon, V, Fox, SH. Medication-related impulse control and repetitive behaviors in Parkinson disease. Arch Neurol. 2007;64(8):1089–1096. doi:10.1001/archneur.64.8.1089.CrossRefGoogle ScholarPubMed
Bacciardi, S, Maremmani, AGI, Rovai, L, et al. Drug (heroin) addiction, bipolar spectrum and impulse control disorders. Heroin Addict Relat Clin Probl. 2013;15:29–36.Google Scholar
Callesen, MB, Weintraub, D, Damholdt, MF, Møller, A. Impulsive and compulsive behaviors among Danish patients with Parkinson’s disease: prevalence, depression, and personality. Parkinsonism Relat Disord. 2014;20(1):22–26. doi:10.1016/j.parkreldis.2013.09.006.CrossRefGoogle Scholar
Georgiev, D, Hamberg, K, Hariz, M, Forsgren, L, Hariz, GM. Gender differences in Parkinson’s disease: a clinical perspective. Acta Neurol Scand. 2017;136:570–584. doi:10.1111/ane.12796.CrossRefGoogle ScholarPubMed