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Adenylyl Cyclase Activity and Mood Disorders: Preliminary Data in Human Brain Postmortem

Published online by Cambridge University Press:  07 November 2014

Lionella Palego ,
Annalisa Giromella ,
Maria Rosa Mazzoni ,
Antonio Giuseppe Naccarato  and
Donatella Marazziti
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Abstract

During the past decade, an increasing interest has been shifted from the study of neuroreceptors to their links with second-messenger pathways. In the present article, we shall briefly review the methodological tools for evaluating adenylyl cyclase activity in several human brain and peripheral models, as well as the studies suggesting its involvement in the pathophysiology of mood disorders. We shall present also some preliminary data obtained in our laboratory providing evidence for the measurement of serotonin-sensitive adenylyl cyclase activity in human brain postmortem.

Type
Feature Articles
Information
CNS Spectrums , Volume 3 , Issue 10 , December 1998 , pp. 70 - 75
Copyright
Copyright © Cambridge University Press 1998

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