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Pharmacologic Approaches in the Treatment of Pathological Gambling

Published online by Cambridge University Press:  07 November 2014

Abstract

Pathological gambling is an understudied disorder that causes significant distress to sufferers, their families, and society. Despite its prevalence among the general population, the impact of pathological gambling remains largely unrecognized by many health care providers. Although a discrete entity, pathological gambling shares salient characteristics with addiction and obsessive-compulsive disoders, and is comorbid with these and other conditions such as attention-deficit hyperactivity disorder in a large number of cases. Recognizing these similarities has significant implications for treatment, as pharmacologic therapies used for these disorders, including serotonergic and mood-stabilizing agents, have shown some degree of efficacy in pathological gambling.

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Feature Articles
Copyright
Copyright © Cambridge University Press 1998

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References

1.Commission on the Review of the National Policy Toward Gambling. Gambling in America. Washington, DC: US Government Printing Office; 1976.Google Scholar
2.Culleton, RP. A Survey of Pathological Gamblers in the State of Ohio. Philadelphia, Pa: Transition Planning Associates; 1985.Google Scholar
3.Volberg, RA. Estimating the prevalence of pathological gambling in the United States. Presented at the Eighth International Conference on Risk and Gambling; August 1990; London, England.Google Scholar
4.Volberg, RA, Steadman, HJ. Refining prevalence estimates of pathological gambling. Am J Psychiatry. 1988;145:502505.Google ScholarPubMed
5.Volberg, RA, Steadman, HJ. Prevalence estimates of pathological gambling in New Jersey and Maryland. Am J Psychiatry. 1989;146:16181619.Google ScholarPubMed
6.Blakeslee, S. Suicide rate higher in three gambling cities, study says. New York Times. December 16, 1997.Google Scholar
7.Lesieur, HR. The female pathological gambler. In: Eadington, WR, ed. Gambling Studies and Proceedings of the Seventh International Conference on Gambling and Risk Taking. Reno, Nev: University of Nevada; 1988.Google Scholar
8.Dickerson, MG. Compulsive Gamblers. London, England: Longman; 1984.Google Scholar
9.Dickerson, M, Hinchy, J, Falve, J. Chasing, arousal and sensation seeking in off-course gamblers. Br J Addict. 1987;82:673680.CrossRefGoogle ScholarPubMed
10.Griffiths, MD. The acquisition, development, and maintenance of fruit machine gambling in adolescents. J Gambling Behav. 1990;6:193204.CrossRefGoogle ScholarPubMed
11.Jacobs, DF. Evidence for a common dissociative-like reaction among addicts. J Compuls Gambling Behav. 1988;4:2737.CrossRefGoogle Scholar
12.Wray, I, Dickerson, MG. Cessation of high frequency gambling and ‘withdrawal’ symptoms. Br J Addict. 1981;76:401405.CrossRefGoogle ScholarPubMed
13.Specker, SM, Carlson, GA, Christenson, GA, Marcotte, M. Impulse control disorders and attention deficit disorder in pathological gamblers. Ann Clin Psychiatry. 1995;7:175179.CrossRefGoogle ScholarPubMed
14.Hollander, E, Wong, CM. Body dysmorphic disorder, pathological gambling, and sexual compulsions. J Clin Psychiatry. 1995;56:712.Google ScholarPubMed
15.Ciarrocchi, J, Richardson, R. Profile of compulsive gamblers in treatment: update and comparisons. J Gambling Behav. 1989;5:5365.CrossRefGoogle Scholar
16.Linden, RD, Pope, HG, Jonas, JM. Pathological gambling and major affective disorder: preliminary findings. J Clin Psychiatry. 1986;47:201203.Google ScholarPubMed
17.McCormick, RA, Russo, AM, Ramirez, LF, et al.Affective disorders among pathological gamblers seeking treatment. Am J Psychiatry. 1984;141:215218.Google ScholarPubMed
18.Ramirez, LF, McCormick, RA, Russo, AM, Taber, JI. Patterns of substance abuse in pathological gamblers undergoing treatment. Addict Behav. 1983;8:425428.CrossRefGoogle ScholarPubMed
19.Lesieur, HR, Blume, SB. Characteristics of pathological gamblers among patients on a psychiatric admissions service. Hosp Community Psychiatry. 1990;41:112.Google ScholarPubMed
20.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
21.Linnoila, M, Virkkunen, M, Scheinin, M, Nuutila, A, Rimon, R, Goodwin, FK. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33:26092614.CrossRefGoogle ScholarPubMed
22.Brown, GL, Linnoila, M. CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. J Clin Psychiatry. 1990;(suppl 51):31–41, 4243.Google ScholarPubMed
23.Moreno, I, Saiz-Ruiz, J, Lopez-Ibor, JJ. Serotonin and gambling dependence. Hum Psychopharmacol. 1991;6:S9S12.CrossRefGoogle Scholar
24.DeCaria, CM, Hollander, E, Grossman, R, et al.Diagnosis, neurobiology and treatment of pathological gambling. J Clin Psychiatry. 1996;57:8084.Google ScholarPubMed
25.Carrasco, JL, Saiz-Ruiz, J, Moreno, I, et al.Low platelet MAO activity in pathological gambling. Acta Psychiatr Scand. 1994;90:427431.CrossRefGoogle ScholarPubMed
26.Fuxe, K, Hokfelt, T, Ungerstedt, U. Morphological and functional aspects of central monoamine neurons. In: Pfeiffer, CC, Smythies, J, eds. International Review of Neurobiology. Vol 13. New York, NY: Academic Press, Inc; 1970:93126.Google Scholar
27.Usdin, E, Smyder, S, eds. Frontiers in Catecholamine Research. Elmsford, NY: Pergamon Press Inc; 1973.Google Scholar
28.Anderson, G, Brown, R. Real and laboratory gambling, sensation-seeking, and arousal. Br J Psychol. 1984;75:401411.CrossRefGoogle ScholarPubMed
29.Boyd, W. Exrefment: the gambler's drug. In: Eadington, WR, ed. Gambling and Society. Springfield, Ill: Charles C. Thomas Publisher; 1976.Google Scholar
30.Brown, R. Arousal and sensation-seeking components in the general explanation of gambling and gambling addictions. Int J Addict. 1986;21:10011016.CrossRefGoogle ScholarPubMed
31.Brown, R. Classical and operant paradigms in the management of gambling addictions. Behav Psychother. 1987;15:111122.CrossRefGoogle Scholar
32.Roy, A, Adinoff, B, Roehrich, L, et al.Pathological gambling: a psychobiological study. Arch Gen Psychiatry. 1988;45:369373.CrossRefGoogle ScholarPubMed
33.Roy, A, Adinoff, B, Linnoila, M. Acting out hostility in normal volunteers: negative correlation with levels of 5-HIAA in cerebrospinal fluid. Psychiatry Res. 1988;24:187194.CrossRefGoogle ScholarPubMed
34.Bergh, C, Eklund, T, Sodersten, P, Nordin, C. Altered dopamine function in pathological gambling. Psychol Med. 1997;27:473475.CrossRefGoogle ScholarPubMed
35.Blum, K, Braverman, ER, Wu, S, et al.Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/ avoidant behaviors (SAB). Mol Psychiatry. 1997;2:239246.CrossRefGoogle Scholar
36.Comings, DE. The molecular genetics of pathological gambling. CNS Spectrums. 1998;3:2037.CrossRefGoogle Scholar
37.Perez de Castro, I, Ibanez, A, Torres, P, Saiz-Ruiz, J, Fernandez-Piqueras, J. Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics. 1997;7:345348.Google Scholar
38.Hollander, E, Frenkel, M, DeCaria, C, Trungold, S, Stein, DJ. Treatment of pathological gambling with clomipramine. Am J Psychiatry. 1992;149:710711.Google ScholarPubMed
39.Swedo, SE, Leonard, HL, Rapoport, JL, Lenane, MC, Goldberger, EL, Cheslow, DL. A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania. N Engl J Med. 1989;321:497501.CrossRefGoogle ScholarPubMed
40.Torres, AR, Cerqueira, AT. Exhibitionism treated with clomipramine. Am J Psychiatry. 1993;150:1274.Google ScholarPubMed
41.The Clomipramine Collaborative Study Group. Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 1991:48:730738.CrossRefGoogle Scholar
42.The Expert Consensus Panel for Obsessive-Compulsive Disorder. Treatment of obsessive-compulsive disorder. J Clin Psychiatry. 1997;58(suppl 4):272.Google Scholar
43.Black, DW. Compulsive buying: a review. J Clin Psychiatry. 1996;57:5054.Google ScholarPubMed
44.Moskowitz, JA. Lithium and lady luck: use of lithium carbonate in compulsive gambling. NY State J Med. 1980;80:785788.Google ScholarPubMed
45.Rocha, FL, Rocha, ME. Kleptomania, mood disorder and lithium. Arq Neuropsiquiatr. 1992;50:543546.CrossRefGoogle ScholarPubMed
46.Christenson, GA, Popkin, MK, Mackenzie, TB, Realmuto, GM. Lithium treatment of chronic hair pulling. J Clin Psychiatry. 1991;52:116120.Google ScholarPubMed
47.Young, JL, Hillbrand, M. Carbamazepine lowers aggression: a review. Bull Am Acad Psychiatry Law. 1994;22:5361.Google ScholarPubMed
48.de Dios Perrino, C, Santo-Domingo Carrasco, J, Lozano Suarez, M. Pharmacological treatment of the intermittent explosive disorder: report of three cases and literature review. Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1995;23:7477.Google ScholarPubMed
49.Cowdry, RW, Gardner, DL. Pharmacotherapy of borderline personality disorder: alprazolam, carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry. 1988;45:111119.CrossRefGoogle ScholarPubMed
50.Haller, R, Hinterhuber, H. Treatment of pathological gambling with carbamazepine. Pharmacopsychiatry. 1994;27:129.CrossRefGoogle ScholarPubMed
51.Soubrie, P. Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci. 1986;9:319364.CrossRefGoogle Scholar
52.Eichelman, B, Thoa, NB, Ng, KY. Facilitated aggression in the rat following 6-hydroxydopamine administration. Physiol Behav. 1972;8:13.CrossRefGoogle ScholarPubMed
53.Thoa, NB, Eichelman, B, Richardson, JS, et al.6-Hydroxydopa depletion of brain norepinephrine and the function of aggressive behavior. Science. 1972:178:7577.CrossRefGoogle ScholarPubMed
54.Eichelman, B, Thoa, NB, Perez-Cruzet, J. Rubidium and cesium: effects on aggression, adrenal enzymes, and amine turnover. Fed Proc. 1972;31:289. Abstract 429.Google Scholar
55.Geyer, MA, Segal, DS. Shock-induced aggression: opposite effects of intraventricularly infused dopamine and norepinephrine. Behav Biol. 1974;10:99104.CrossRefGoogle ScholarPubMed
56.Petty, F, Davis, LL, Kabel, D, Kramer, GL. Serotonin dysfunction disorders: a behavioral neurochemistry perspective. J Clin Psychiatry. 1996;57:1116.Google ScholarPubMed
57.Carlton, PL, Manowitz, P, McBride, H, Nora, R, Swartzburg, M, Goldstein, LJ. Attention deficit disorder and pathological gambling. Clin Psychiatry. 1987:48:487488.Google ScholarPubMed
58.Marston, AR, Jacobs, DF, Singer, RD, Widaman, KF, Little, TD. Characteristics of adolescents at risk for compulsive overeating on a brief screening test. Adolescence. 1988;23:5965.Google ScholarPubMed
59.Lesieur, HR, Blume, SB. Evaluation of patients treated for pathological gambling in a combined alcohol, substance abuse and pathological gambling treatment unit using the Addiction Severity Index. Br J Addict. 1991:86:10171028.CrossRefGoogle Scholar
60.Lesieur, HR, Blume, SB, Zoppa, RM. Alcoholism, drug abuse, and gambling. Alcohol Clin Exp Res. 1986:10:3338.CrossRefGoogle Scholar
61.Feigelman, W, Kleinman, PH, Lesieur, HR, Millman, RB, Lesser, ML. Pathological gambling among methadone patients. Drug Alcohol Depend. 1995;39:7581.CrossRefGoogle ScholarPubMed
62.Silva, H. Trichotillomania: clinical case [in Spanish]. Rev Med Chil. 1997;125:457459.Google Scholar
63.Casals-Ariet, C, Cullen, K. Exhibitionism treated with clomipramine. Am J Psychiatry. 1993;150:12731274.Google ScholarPubMed
64.Hollander, E, Benzaquen, S. Is there a distinct OCD spectrum? CNS Spectrums. 1996; 1:1726.CrossRefGoogle Scholar
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