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Kounis syndrome following allergy injection in a paediatric patient

Published online by Cambridge University Press:  26 July 2022

Maria Mason  and
Matthew D. Campbell Open the ORCID record for Matthew D. Campbell [Opens in a new window]
Maria Mason
Affiliation:
University of Oklahoma Health Science Center, Department of Pediatrics, Oklahoma City, United States of America
Matthew D. Campbell*
Affiliation:
University of Oklahoma Health Science Center, Department of Pediatrics, Oklahoma City, United States of America
*
Author for correspondence: Matthew D. Campbell, MD, University of Oklahoma Health Science Center, Department of Pediatrics, Section of Cardiology, 1200 Children’s Avenue, #NP 2350, Oklahoma City, OK 73104, United States of America. Tel: +1 405 271 4411; Fax: +1 405 271 5055. E-mail: matthew-campbell@ouhsc.edu
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Abstract

Kounis syndrome is the concurrence of acute coronary syndrome or coronary vasospasm with conditions associated with the release of inflammatory cytokines through mast cell activation in the setting of allergic or anaphylactic reactions. Many identified triggers have been identified in paediatric patients including exposures, drugs, and immunisations; however, to our knowledge this is the first case report of Kounis syndrome linked to immunotherapy. We present a case of a 9-year-old with seasonal allergies presenting with clinical symptoms of Kounis syndrome following her weekly subcutaneous injection of allergens. Clinicians need a high index of suspicion for Kounis syndrome in patients who develop systemic signs of anaphylaxis with clinical, laboratory, electrocardiographic, and echocardiographic findings of acute coronary syndrome to help direct therapy and improve outcomes.

Keywords

Kounispediatric cardiologyallergy immunotherapyanaphylaxis
Type
Brief Report
Information
Cardiology in the Young , Volume 33 , Issue 2 , February 2023 , pp. 331 - 333
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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