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Importance of adhesion molecules for children with congenital heart disease

Published online by Cambridge University Press:  16 April 2012

Ayşe Yıldırım ,
Aysu T. Karaağaç ,
Fusun Güzelmeriç ,
Nihat Çine  and
Naci C. Öner
Ayşe Yıldırım*
Affiliation:
Department of Pediatric Cardiology, Istanbul, Turkey
Aysu T. Karaağaç
Affiliation:
Department of Pediatry, Istanbul, Turkey
Fusun Güzelmeriç
Affiliation:
Department of Anesthesiology and Reanimation, Istanbul, Turkey
Nihat Çine
Affiliation:
Department of Cardiovascular Surgery, Istanbul, Turkey
Naci C. Öner
Affiliation:
Department of Pediatric Cardiology, Istanbul, Turkey
*
Correspondence to: A. Yıldırım, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Denizer Caddesi Cevizli Kavşağı No: 2, 34846 Kartal/Istanbul, Turkey. Tel: +90 2164594440; Fax: +90 2164596321; E-mail: ayildirimmd@yahoo.com
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Abstract

Background

The aim of our study was to compare the blood levels of adhesion molecules in children with different heart diseases and pulmonary flow rates.

Methods

In this study, we evaluated the levels of soluble intercellular adhesion molecule-1 and soluble vascular cellular adhesion molecule-1 in blood samples of 65 children with different congenital heart diseases. The patients were divided into four groups according to their pulmonary blood flow. The first group had increased pulmonary blood flow with pulmonary hypertension and left-to-right shunt. The second group had increased pulmonary blood flow without pulmonary hypertension and left-to-right shunt. The third group had decreased pulmonary blood flow with cyanotic congenital heart disease and the fourth group had normal pulmonary blood flow with left ventricle outflow tract obstruction and aortic stenosis.

Result

The highest soluble intercellular and vascular cellular adhesion molecule-1 levels with the mean values of 420.2 nanograms per millilitre and 1382.1 nanograms per millilitre, respectively, were measured in the first group and the lowest levels with the mean values of 104.4 and 358.6 nanograms per millilitre, respectively, were measured in the fourth group. The highest pulmonary blood pressure levels were found in the first group.

Conclusion

Endothelial activity is influenced not only by left-to-right shunt with pulmonary hypertension, but also by decreased pulmonary blood flow in cyanotic heart diseases. Adhesion molecules are valuable markers of endothelial activity in congenital heart diseases, and they are influenced by pulmonary blood flow rate.

Keywords

Endothelial activitypulmonary blood flowcardiac failure
Type
Original Article
Information
Cardiology in the Young , Volume 23 , Issue 1 , February 2013 , pp. 35 - 40
Copyright
Copyright © Cambridge University Press 2012

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