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Brainstem auditory-evoked responses among children afflicted by severely hypoxic CHD

Published online by Cambridge University Press:  05 September 2022

F. Bernardo Pliego-Rivero ,
Keila Isaac-Olivé  and
Gloria A. Otero Open the ORCID record for Gloria A. Otero [Opens in a new window]
F. Bernardo Pliego-Rivero
Affiliation:
Laboratory of Neurochemistry, Universidad Autonoma del Estado de Mexico, Toluca, Mexico
Keila Isaac-Olivé
Affiliation:
Laboratory of Theragnostics Research, Universidad Autonoma del Estado de Mexico, Toluca, Mexico
Gloria A. Otero*
Affiliation:
Laboratory of Neurophysiology, Universidad Autonoma del Estado de Mexico, Toluca, Mexico
*
Author for correspondence: Dr. Gloria A. Otero, Universidad Autonoma del Estado de Mexico, Toluca, 50000, Mexico. Tel: + 52 722 350 8866. Email: oeog45@gmail.com
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Abstract

Main aim:

To electrophysiologically determine the impact of moderate to severe chronic hypoxia (H) resulting from a wide array of CHD (HCHD) conditions on the integrity of brainstem function.

Materials and methods:

Applying brainstem auditory-evoked response methodology, 30 chronically afflicted HCHD patients, who already had undergone heart surgery, were compared to 28 healthy control children (1–15 yo) matched by age, gender and socioeconomic condition. Blood oxygen saturation was clinically determined and again immediately before brainstem auditory-evoked response testing.

Results:

Among HCHD children, auditory wave latencies (I, III and V) were significantly longer (medians: I, 2.02 ms; III, 4.12 ms, and; V, 6.30 ms) compared to control (medians: I, 1.67ms; III, 3.72 ms, and; V, 5.65 ms), as well as interpeak intervals (HCHD medians: I-V, 4.25 ms, and; III-V, 2.25ms; control medians: I-V, 3.90 ms and, III-V, 1.80 ms) without significant differences in wave amplitudes between groups. A statistically significant and inverse correlation between average blood oxygen saturation of each group (control, 94%; HCHD, 78%) and their respective wave latencies and interpeak intervals was found.

Conclusions:

As determined by brainstem auditory-evoked responses, young HCHD patients manifestly show severely altered neuronal conductivity in the auditory pathway strongly correlated with their hypoxic condition. These observations are strongly supported by different brainstem neurological and image studies showing that alterations, either in microstructure or function, result from the condition of chronic hypoxia in CHD. The non-altered wave amplitudes are indicative of relatively well-preserved neuronal relay nuclei.

Keywords

Congenital heart diseasebrain stem auditory-evoked responseschronic hypoxiachildren
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 9 , September 2023 , pp. 1569 - 1573
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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