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Atherosclerosis—a disease that begins in childhood

Published online by Cambridge University Press:  19 August 2008

David S. Celermajer ,
Keld E. Sorensen  and
John E. Deanfield
David S. Celermajer
Affiliation:
Cardiothoracic UnitHospital for Sick ChildrenGreat Ormond StreetLondon, WCIN3JH, United Kingdom Tel. 071 4045094; Fax. 071 831 4850
Keld E. Sorensen
Affiliation:
Cardiothoracic UnitHospital for Sick ChildrenGreat Ormond StreetLondon, WCIN3JH, United Kingdom Tel. 071 4045094; Fax. 071 831 4850
John E. Deanfield
Affiliation:
Cardiothoracic UnitHospital for Sick ChildrenGreat Ormond StreetLondon, WCIN3JH, United Kingdom Tel. 071 4045094; Fax. 071 831 4850
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Abstract

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Type
Editorials
Information
Cardiology in the Young , Volume 4 , Issue 3 , July 1994 , pp. 224 - 227
Copyright
Copyright © Cambridge University Press 1994

References

Ruffer, MA.On arterial lesions found in Egyptian mummies. J Pathol Bacreriol 1911; 15: 453–462.CrossRefGoogle Scholar
Stary, HC.Evolution and progression of atherosclerotic lesions in coronary arteries in children and young adults. Arteriosclerosis 1989; 99(SuppI Iyes): I 19–I 32.Google Scholar
Enos, WF, Holmes, RH, Beyer, J.Coronary disease among United States soldiers killed in action in Korea: preliminary report. J Am Med Assoc 1953; 152: 1090–1093.CrossRefGoogle ScholarPubMed
PDAY investigators. Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determi nants of Atherosclerosis in Youth (PDAY) Research Group. J Am Med Assoc 1990; 264: 3018–3024.CrossRefGoogle Scholar
Klag, MJ, Ford, DE, Mead, LA, He, J, Whelton, PK, Liang, K-Y, Levine, DM.Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993; 328: 313–318.CrossRefGoogle ScholarPubMed
Cambien, F, Poirier, O, Lecerf, L, Evans, A, Cambou, J-P, Arveiler, D, Luc, G, Bard, J-M, Bara, L, Richard, S, Tiret, L, Amouyel, P, Alhenc-Gelas, F, Soubrier, F.Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for niyocardial infiirction. Nature 1992; 359: 641–644.CrossRefGoogle Scholar
Barker, DJP.Fetal and Infant Origins of Adult Disease. BMJ publications, London, 1992.Google Scholar
Celermajer, DS, Sorensen, KE, Gooch, VM, Spiegeihalter, DJ, Miller, OI, Sullivan, ID, Lloyd, JE, Deanfield, JE.Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111–1115.CrossRefGoogle ScholarPubMed
Petty, RG, Pearson, JD.Endothelium—the axis of vascular health and disease. J Royal Coil Phys 1989; 23: 92–101.Google ScholarPubMed
Ross, R.The pathogenesis of atheroscierosis—an update. N EngI J Med 1986; 8: 488–500.CrossRefGoogle Scholar
Henderson, AH.Endothelium in control. Br Heart J 1991; 65: 116–125.CrossRefGoogle ScholarPubMed
Harrison, DG, Armstong, ML, Freiman, PC, Heistad, DD.Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. J Clin Invest 1987; 80: 1808–1811.CrossRefGoogle ScholarPubMed
McLenachan, JM, Vita, J, Fish, RD, Yeung, AC, Ganz, P, Selwyn, AP.Early evidence of endothelial vasodilator dysfunction at coronary branch points. Circulation 1990; 82: 1169–1173.CrossRefGoogle ScholarPubMed
Moncada, S, Palmer, RMJ, Higgs, EA.Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Reviews 1991;43: 109–142.Google ScholarPubMed
Cooke, JP, Singer, AH, Zera, P, Rowan, RA, Billingharn, ME.Antiatherogenic effects of L-arginine in the hypercholester olemic rabbit J Clin Invest 1992; 90: 1168–1172.CrossRefGoogle Scholar
Cohen, M, Fuster, V, Steele, PM, Driscoll, D, McGoon, DC.Coarctation of the aorta: Long-term follow-up and prediction of outcome after surgical correction. Circulation 1989; 80: 840–845.CrossRefGoogle ScholarPubMed
Davis, JW, Shelton, L, Eigenberg, DA, Hignite, CE, Watanabe, IS.Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. Clin Pharmacol Ther 1985; 37: 529–533.CrossRefGoogle ScholarPubMed
Ludmer, PL, Selwyn, AP, Shook, TL, Mudge, GW, Ganz, P.Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N EnglJ Med 1986; 315: 1046–1051.CrossRefGoogle ScholarPubMed
Nabel, EG, Selwyn, AP, Ganz, P.Large coronary arteries in humans are responsive to changing blood flow: an endorhelium dependent mechanism that fails in patients with atherosclerosis. J Am Coil Cardiol 1990; 16: 349–356.CrossRefGoogle ScholarPubMed
Pohl, U, Holtz, J, Busse, R, Bassenge, E.Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986; 8: 37–44.CrossRefGoogle ScholarPubMed
Rubanyi, GM, Romero, C, Vanhoutte, PM.Flow-induced release of endothelium-derived relaxing factor. AmJ Physiol 1986; 250: 1115–1119.Google ScholarPubMed
Sorensen, KE, Celermajer, DS, Georgakopoulos, D, Hatcher, G, Betteridge, DJ, Deanfield, JE.Impairment of endothelium dependent vasodilation is an early event in children with familial hypercholesterolemia, and is related to the Lp (a) level. J Chin Invest 1994; 93: 50–55.CrossRefGoogle Scholar
Celermajer, DS, Sorensen, KE, Ryalls, M, Robinson, J, Thomas, O, Leonard, JV, Deanfleld, JE.Endothelial dysfunction occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol 1993; 22: 834–838.CrossRefGoogle Scholar
Celermajer, DS, Sorensen, KE, Georgakopoulos, D, Bull, C, Thomas, O, Robinson, J, Deanfield, JE.Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993; 88: 2149–2155.CrossRefGoogle ScholarPubMed
Wendelhag, I, Gustavsson, T, Suurkula, M, Berglund, G, Wikstrand, U.Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of computerized analyzing system. Clin Physiol 1991; 11:565–577.CrossRefGoogle Scholar
Belcaro, G, Barsotti, A, Nicolaides, AN.Ultrasonic biopsy—a non-invasive screening technique. Vasa 1991; 20: 40–50.Google ScholarPubMed
Wendelhag, I, Wiklund, O, Wikstrand, J.Arterial wall thickness in familial hypercholesterolemia. Ultrasound measurement of intima thickness in thecommon carotid artery. Arterioscler Thromb 1992; 12: 70–77.CrossRefGoogle Scholar
ARIC investigators. The Atherosclerosis Risk in Communities (ARIC) study; design and objectives. Am J Epidemiol 1989; 129: 687–699.CrossRefGoogle Scholar
Salonen, R, Salonen, JT.Determinants of carotid intima-media thickness: a population based ultrasonography study in Eastern Finnish men. J Int Med 1991; 229: 225–231.CrossRefGoogle ScholarPubMed
Salonen, JT, Salonen, R.Ultrasound B-mode imaging in obser vational studies of atherosclerotic progression. Circulation 1993; 87(Suppl IIyes): II 56–I 65.Google Scholar
Kwiterovich, PO Jr. Diagnosis and management of familial dyslipoproteinemia in children and adolescents: current issues in pediatric and adolescent endocrinology. Pediatr Clin North Am 1990; 37: 1489–1523.CrossRefGoogle Scholar
Luscher, TF, Vanhoutte, PM, Raij, L.Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. Hypertension 1987; 9(Suppl IIIyes): 193–197.CrossRefGoogle ScholarPubMed
Creager, MA, Gallagher, SH, Girerd, XJ, Coleman, S, Dzau, VJ, Cooke, JP.L-arginine improves endothelium-dependentvasodi latation in hypercholesterolemic humans. J Clin Invest 1992; 90: 1248–1253.CrossRefGoogle ScholarPubMed
Drexler, H, Zeiher, AM, Meinzer, K, Just, H.Correction of endothelial dysfunction in coronary microcirculation of hyper cholesterolemic patients byL-arginine. Lancet 1991; 338: 1546–1550.CrossRefGoogle Scholar