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Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians

Published online by Cambridge University Press:  17 June 2015

Alexander V. Sorokin ,
Kazuhiko Kotani ,
Olga Y. Bushueva  and
Alexey V. Polonikov
Alexander V. Sorokin*
Affiliation:
Department of Internal Medicine, Kursk State Medical University, Kursk, Russia
Kazuhiko Kotani
Affiliation:
Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
Olga Y. Bushueva
Affiliation:
Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russia
Alexey V. Polonikov
Affiliation:
Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russia
*
Correspondence to: A. Sorokin, MD, PhD, Department of Internal Medicine, Kursk State Medical University, K. Marx St.3, 305041 Kursk, Russia. Tel: +7 471 258 8132; Fax: +7 471 256 7399; E-mail: drsorokin@hotmail.com
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Abstract

The cardio-ankle vascular index is a measure of arterial stiffness, whereas oxidative stress underlies arterial pathology. This study aimed to investigate the association between the cardio-ankle vascular index and antioxidant-related gene polymorphisms in young Russians. A total of 89 patients (mean age, 21.6 years) were examined by the cardio-ankle vascular index and for 15 gene polymorphisms related to antioxidant enzymes including FMO3 (flavin-containing monooxygenase 3), GPX1 (glutathione peroxidase 1), and GPX4 (glutathione peroxidase 4). A higher cardio-ankle vascular index level was detected in carriers with the KK-genotype of FMO3 polymorphism rs2266782 than in those without (mean levels: 6.2 versus 5.6, respectively, p<0.05). Similarly, a higher cardio-ankle vascular index level was seen in carriers with the CC-genotype of GPX4 polymorphism rs713041 than in those without (6.0 versus 5.5, respectively, p<0.05). We did not observe significant associations between the cardio-ankle vascular index levels and the other gene polymorphisms. Although carriers with the LL-genotype of GPX1 polymorphism rs1050450 showed a higher diastolic blood pressure level than those without, the polymorphism did not affect the cardio-ankle vascular index level. This study showed a significant association between rs2266782 and rs713041 polymorphisms and arterial stiffness, as measured by the cardio-ankle vascular index, in young Russians. The pathways utilised by antioxidant enzymes may be responsible for early arterial stiffening in the Russian population.

Keywords

Ankle-brachial indexcardio-ankle vascular indexarterial stiffnessantioxidant enzymesgene polymorphisms
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 4 , April 2016 , pp. 677 - 682
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Copyright
© Cambridge University Press 2015 

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