Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-23T23:06:26.268Z Has data issue: false hasContentIssue false
  • English
  • Français

Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians

Published online by Cambridge University Press:  17 June 2015

Alexander V. Sorokin ,
Kazuhiko Kotani ,
Olga Y. Bushueva  and
Alexey V. Polonikov
Alexander V. Sorokin*
Affiliation:
Department of Internal Medicine, Kursk State Medical University, Kursk, Russia
Kazuhiko Kotani
Affiliation:
Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
Olga Y. Bushueva
Affiliation:
Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russia
Alexey V. Polonikov
Affiliation:
Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russia
*
Correspondence to: A. Sorokin, MD, PhD, Department of Internal Medicine, Kursk State Medical University, K. Marx St.3, 305041 Kursk, Russia. Tel: +7 471 258 8132; Fax: +7 471 256 7399; E-mail: drsorokin@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

The cardio-ankle vascular index is a measure of arterial stiffness, whereas oxidative stress underlies arterial pathology. This study aimed to investigate the association between the cardio-ankle vascular index and antioxidant-related gene polymorphisms in young Russians. A total of 89 patients (mean age, 21.6 years) were examined by the cardio-ankle vascular index and for 15 gene polymorphisms related to antioxidant enzymes including FMO3 (flavin-containing monooxygenase 3), GPX1 (glutathione peroxidase 1), and GPX4 (glutathione peroxidase 4). A higher cardio-ankle vascular index level was detected in carriers with the KK-genotype of FMO3 polymorphism rs2266782 than in those without (mean levels: 6.2 versus 5.6, respectively, p<0.05). Similarly, a higher cardio-ankle vascular index level was seen in carriers with the CC-genotype of GPX4 polymorphism rs713041 than in those without (6.0 versus 5.5, respectively, p<0.05). We did not observe significant associations between the cardio-ankle vascular index levels and the other gene polymorphisms. Although carriers with the LL-genotype of GPX1 polymorphism rs1050450 showed a higher diastolic blood pressure level than those without, the polymorphism did not affect the cardio-ankle vascular index level. This study showed a significant association between rs2266782 and rs713041 polymorphisms and arterial stiffness, as measured by the cardio-ankle vascular index, in young Russians. The pathways utilised by antioxidant enzymes may be responsible for early arterial stiffening in the Russian population.

Keywords

Ankle-brachial indexcardio-ankle vascular indexarterial stiffnessantioxidant enzymesgene polymorphisms
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 4 , April 2016 , pp. 677 - 682
Check for updates
Copyright
© Cambridge University Press 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Petrukhin, IS, Lunina, EY. Cardiovascular disease risk factors and mortality in Russia: challenges and barriers. Public Health Rev 2012; 33: 436–449.Google Scholar
2. Polonikov, AV, Vialykh, EK, Churnosov, MI, et al. The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension. Hypertens Res 2012; 35: 507–512.Google Scholar
3. Hulsmans, M, Van Dooren, E, Holvoet, P. Mitochondrial reactive oxygen species and risk of atherosclerosis. Curr Atheroscler Rep 2012; 14: 264–276.Google Scholar
4. Hulsmans, M, Holvoet, P. The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med 2010; 14: 70–78.Google Scholar
5. Li, H, Horke, S, Forstermann, U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 2014; 237: 208–219.Google Scholar
6. Shirai, K, Utino, J, Otsuka, K, Takata, M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb 2006; 13: 101–107.Google Scholar
7. Kotani, K, Miyamoto, M, Taniguchi, N. Clinical significance of the cardio-ankle vascular index (CAVI) in hypertension. Curr Hypertens Rev 2010; 6: 251–253.Google Scholar
8. Shirai, K, Hiruta, N, Song, M, et al. Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives. J Atheroscler Thromb 2011; 18: 924–938.Google Scholar
9. Sorokin, A, Kotani, K, Bushueva, O, Taniguchi, N, Lazarenko, V. The cardio-ankle vascular index and ankle-brachial index in young Russians. J Atheroscler Thromb 2015; 22: 211–218.Google Scholar
10. Cooper, DN, Nussbaum, RL, Krawczak, M. Proposed guidelines for papers describing DNA polymorphism-disease associations. Hum Genet 2002; 110: 207–208.Google Scholar
11. Abdel-Rahman, SZ, el-Zein, RA, Anwar, WA, Au, WW. A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies. Cancer Lett 1996; 107: 229–233.Google Scholar
12. Sachse, C, Ruschen, S, Dettling, M, et al. Flavin monooxygenase 3 (FMO3) polymorphism in a white population: allele frequencies, mutation linkage, and functional effects on clozapine and caffeine metabolism. Clin Pharmacol Ther 1999; 66: 431–438.Google Scholar
13. Hisamuddin, IM, Yang, VW. Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives. Pharmacogenomics 2007; 8: 635–643.CrossRefGoogle ScholarPubMed
14. Cashman, JR, Zhang, J, Leushner, J, Braun, A. Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms. Drug Metab Dispos 2001; 29: 1629–1637.Google Scholar
15. Bushueva, O, Solodilova, M, Churnosov, M, Ivanov, V, Polonikov, A. the flavin-containing monooxygenase 3 gene and essential hypertension: the joint effect of polymorphism E158K and cigarette smoking on disease susceptibility. Int J Hypertens 2014; 2014: 712169.Google Scholar
16. Hernandez, D, Addou, S, Lee, D, Orengo, C, Shephard, EA, Phillips, IR. Trimethylaminuria and a human FMO3 mutation database. Hum Mutat 2003; 22: 209–213.Google Scholar
17. Bennett, BJ, de Aguiar Vallim, TQ, Wang, Z, et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab 2013; 17: 49–60.Google Scholar
18. Shih, DM, Wang, Z, Lee, R, et al. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res 2015; 56: 22–37.Google Scholar
19. Wang, Z, Klipfell, E, Bennett, BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011; 472: 57–63.Google Scholar
20. Seiler, A, Schneider, M, Forster, H, et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab 2008; 8: 237–248.Google Scholar
21. Maiorino, M, Bosello, V, Ursini, F, et al. Genetic variations of gpx-4 and male infertility in humans. Biol Reprod 2003; 68: 1134–1141.Google Scholar
22. Villette, S, Kyle, JA, Brown, KM, et al. A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood Cells, Mol Dis 2002; 29: 174–178.Google Scholar
23. Serhan, CN. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 2007; 25: 101–137.Google Scholar
24. Karunasinghe, N, Han, DY, Zhu, S, et al. Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand. Genes Nutr 2012; 7: 179–190.Google Scholar
25. Prabhakar, R, Morokuma, K, Musaev, DG. Peroxynitrite reductase activity of selenoprotein glutathione peroxidase: a computational study. Biochemistry 2006; 45: 6967–6977.Google Scholar
26. Rybka, J, Kupczyk, D, Kedziora-Kornatowska, K, et al. Glutathione-related antioxidant defense system in elderly patients treated for hypertension. Cardiovasc Toxicol 2011; 11: 1–9.CrossRefGoogle ScholarPubMed
27. Espinola-Klein, C, Rupprecht, HJ, Bickel, C, et al. Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis. Am J Cardiol 2007; 99: 808–812.Google Scholar
28. Hamanishi, T, Furuta, H, Kato, H, et al. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. Diabetes 2004; 53: 2455–2460.CrossRefGoogle ScholarPubMed
29. Glagov, S, Zarins, CK, Masawa, N, Xu, CP, Bassiouny, H, Giddens, DP. Mechanical functional role of non-atherosclerotic intimal thickening. Front Med Biol Eng 1993; 5: 37–43.Google Scholar
30. Ando, J, Yamamoto, K. Effects of shear stress and stretch on endothelial function. Antioxid Redox Signal 2011; 15: 1389–1403.CrossRefGoogle ScholarPubMed
31. Vlachopoulos, C, Xaplanteris, P, Baou, K, et al. Common single nucleotide polymorphisms of the p22phox NADPH oxidase subunit do not influence aortic stiffness in young, healthy adults. Hellenic J Cardiol 2012; 53: 352–356.Google Scholar