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Amiodarone-induced pulmonary toxicity in an adolescent

Published online by Cambridge University Press:  19 August 2008

Shyam S. Kothari ,
Sharada Balijepally  and
Karuna Taneja
Shyam S. Kothari*
Affiliation:
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
Sharada Balijepally
Affiliation:
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
Karuna Taneja
Affiliation:
Department of Cardiac-Radiology, All India Institute of Medical Sciences, New Delhi, India
*
Dr. SS Kothari, MD, DM, Department of Cardiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi – 110 029, India. Tel: 661123–2824851; Fax 91–011–686–2663; e-mail: kothari@medinst.ernet.in
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Abstract

We report amiodarone-induced pulmonary toxicity in an 18-year-old who had undergone corrective surgery for tetralogy of Fallot 4 years earlier, and was treated with amiodarone because of recurrent malignant postoperative ventricular tachyarrhythmias. Toxicity was recognized on the basis of clinical features, chest X-ray, high-resolution contrast enhanced computerized tomography, and resolution of the findings subsequent to withdrawal of amiodarone and treatment with steroids. pulmonary toxicity due to amiodarone, as far as we know, has not been reported in children and young adults, and its occurence even in young adults requires wider appreciation.

Keywords

Amiodaronelungdrug toxicity
Type
Brief Reports
Information
Cardiology in the Young , Volume 9 , Issue 2 , March 1999 , pp. 194 - 196
Copyright
Copyright © Cambridge University Press 1999

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References

1.Dusman, RE, Stanton, MS, Miles, WM, Klein, LS, Zipes, DP, Fineberg, NS, Heger, JJ. Clinical features of amiodaroneinduced pulmonary toxicity. Circulation 1990; 82: 51–59.Google Scholar
2.Guccione, PPaul, T, Garson, A. Long-term follow-up of amiodarone therapy in the young:continued efficacy, unimpaired growth, moderate side effects. J Am Coll cardiol 1990; 15: 1118–1124.Google Scholar
3.Garson, A, Gillette, PC, McVey, P, Hesslein, PS, Porter, CJ, Angell, LK, Kaldis, LC, Hittner, HM. Amiodarone treatment of critical arrhythimas in children and young adults. J Am Coll cardiol 1984; 4: 749–755.CrossRefGoogle Scholar
4.Valle, JM, Alvarez, D, Antunez, J, Valdes, L. Bronchiolitis obliterans organizing pneumonia secondary to amiodarone:a rare aetiology. Eur Respir J 1995; 8: 470–471.CrossRefGoogle Scholar
5.Herre, JM, Ross, BA. Amiodarone in children: borrowing from the future? J Am Coll Cardiol 1990; 15: 1125–1126.CrossRefGoogle ScholarPubMed
6.Reasor, MJ, Kacew, S. An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity. Proc Soc Exp Biol Med 1996; 212: 297–304.CrossRefGoogle ScholarPubMed
7.vander, Zeyden H, Zandstra, D, van Hengstum, M. Low dose amiodarone pulmonary toxicity in a patient with a history of pneumonectomy. Intensive Care Med 1992; 18: 422–423.CrossRefGoogle Scholar