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Successful treatment of disseminated adenovirus infection with cidofovir and intravenous immunoglobulin in an infant following heart transplant

Part of: Infectious

Published online by Cambridge University Press:  25 April 2018

Ryan M. Serrano*
Affiliation:
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN, USA
Robert K. Darragh
Affiliation:
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN, USA
John J. Parent
Affiliation:
Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN, USA
*
Author for correspondence: R. M. Serrano, Pediatric Cardiology, 705 Riley Hospital Drive, RR 127, Indianapolis, IN 46202, USA. Tel: +317 274 8906; Fax: +317 274 4022; E-mail: rserran@iupui.edu

Abstract

For most patients, adenoviruses cause few acute health concerns and are often self-limiting. Patients who are immunocompromised or immunosuppressed, however, are at risk for disseminated adenovirus and suffer high morbidity and mortality, without well-defined treatment options. We report the case of a 9-month-old boy who was successfully treated for disseminated adenovirus infection with intravenous immunoglobulin and cidofovir 3 months post heart transplant, tailored to serum adenoviral load and clinical response. We emphasise the importance of early identification, monitoring, and a potentially novel treatment in the paediatric cardiac transplant population with disseminated adenovirus infection.

Type
Brief Report
Copyright
© Cambridge University Press 2018 

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References

1. Ison, M. Adenovirus infections in transplant recipients. Clin Infect Dis 2006; 43: 331339.CrossRefGoogle ScholarPubMed
2. Munoz, F, Piedra, P, Demmler, G. Disseminated adenovirus disease in immunocompromised and immunocompetent children. Clin Infect Dis 1998; 27: 11941200.CrossRefGoogle ScholarPubMed
3. Yusuf, U, Hale, G, Gu, Z, et al. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation 2006; 81: 13981404.CrossRefGoogle ScholarPubMed
4. Carter, B, Karpen, S, Quiros-Tejeira, R, et al. Intravenous cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation 2002; 74: 10501052.CrossRefGoogle Scholar
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