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Observations on obesity patterns in tetralogy of Fallot patients from childhood to adulthood

Published online by Cambridge University Press:  22 September 2016

David A. Briston
Division of Pediatric Cardiology, Children’s Hospital at Montefiore, Montefiore Medical Center, Bronx, New York, United States of America
Aarthi Sabanayagam
Einstein Montefiore Center for Heart and Vascular Care, Montefiore Medical Center, Bronx, New York, United States of America
Ali N. Zaidi*
Division of Pediatric Cardiology, Children’s Hospital at Montefiore, Montefiore Medical Center, Bronx, New York, United States of America Einstein Montefiore Center for Heart and Vascular Care, Montefiore Medical Center, Bronx, New York, United States of America Montefiore Adult Congenital Heart Disease (MAtCH) Program, Einstein Montefiore Center for Heart and Vascular Care, Montefiore Medical Center, Bronx, New York, United States of America
Correspondence to: A. N. Zaidi, MD, Montefiore Adult Congenital Heart Disease (MAtCH) Program, Montefiore Einstein Center for Heart and Vascular Care, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, NY 10467, United States of America. Tel: +1 718 920 5882; Fax: +1 718 920 6798; E-mail:


Obesity is increasingly prevalent, and abnormal body mass index is a risk factor for cardiovascular disease. There are limited data published regarding body mass index and CHD. We tested the hypothesis that body mass index and obesity prevalence are increasing in patients with tetralogy of Fallot over time by analysing time since surgery, age, height, weight, and body mass index among tetralogy of Fallot patients and demographic data from age-matched controls. NYHA class and left ventricular ejection fraction were analysed in adults. Body mass index was categorised into normal, overweight, and obese in this single-centre, retrospective chart review. Data were collected from 137 tetralogy of Fallot patients (71 men:66 women), of whom 40 had body mass index >25 kg/m2. Tetralogy of Fallot patients aged <6 years had lower body mass index (15.9 versus 17.1; p=0.042) until 16–20 years of age (27.4 versus 25.4; p=0.43). For adult tetralogy of Fallot patients, the mean body mass index was 26.5 but not statistically significantly different from the control cohort. Obese adult patients had significantly higher average NYHA class compared with those of normal weight (p=0.03), but no differences in left ventricular ejection fraction by echocardiography (p=0.55) or cardiac MRI (p=0.26) were noted. Lower body mass index was observed initially in tetralogy of Fallot patients, but by late adolescence no significant difference was observed. As adults, tetralogy of Fallot patients with higher body mass index had increased NYHA class but similar left ventricular ejection fraction.

Original Articles
© Cambridge University Press 2016 

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