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Modified Calgary score in differential diagnosis between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope in children

Published online by Cambridge University Press:  09 October 2012

Jinyan Yang
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Lulu Zhu
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Stella Chen
Affiliation:
Department of Biological Sciences, University of California, San Diego, La Jolla, CA, United States
Xueying Li
Affiliation:
Department of Medical Statistics, Peking University First Hospital, Beijing, China
Qingyou Zhang
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Fengwen Zhang
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Li Chen
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Chaoshu Tang
Affiliation:
Department of Physiology and Pathophysiology, Peking University Health Science Centre, Beijing, China Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, China
Junbao Du
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
Hongfang Jin*
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing, China
*
Correspondence to: Prof. H. Jin, Department of Pediatrics, Peking University First Hospital, Beijing 100034, P. R. China. Tel: +8610 83573209; Fax: +8610 66530532; E-mail: jinhongfang51@126.com

Abstract

The present study was designed to analyse the usefulness of a modified Calgary score system during differential diagnosis between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope through a large sample sized clinical investigation. The study included 213 children, including 101 boys and 112 girls, with cardiac syncope or postural orthostatic tachycardia syndrome-associated syncope in the age group of 2–19 years (mean 11.8 ± 2.9 years). A modified Calgary score was created, which was analysed to predict differential diagnoses between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope using a receiver operating characteristic curve. The median of modified Calgary scores for cardiac syncope was −5.0, which significantly differed from that of postural orthostatic tachycardia syndrome (0.0; p < 0.01). The sensitivity and specificity of a differentiation score of less than −2.5 was 96.3% and 72.7%, respectively. Owing to the fact that the modified Calgary score was an integer, when less than −3.0 the diagnosis could be considered as cardiac syncope. The modified Calgary score could be used to make an initial differential diagnosis between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope in the clinic.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2012 

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