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The impact of the American Heart Association guidelines on patients treated for incomplete Kawasaki disease

Part of: Infectious

Published online by Cambridge University Press:  06 September 2021

Megan M. Blaney*
Affiliation:
Division of Pediatrics, University of Utah, Salt Lake City, UT, USA
Richard V. Williams
Affiliation:
Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT, USA
Igor A. Areinamo
Affiliation:
Division of Pediatrics, Children’s Mercy Kansas City, Kansas City, MO, USA
Michael Sauer
Affiliation:
Division of Pediatrics, University of Utah, Salt Lake City, UT, USA
Lloyd Y. Tani
Affiliation:
Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT, USA
Zhining Ou
Affiliation:
Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT, USA
L. LuAnn Minich
Affiliation:
Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT, USA
Dongngan T. Truong
Affiliation:
Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT, USA
*
Author for correspondence: M.M. Blaney, MD, Division of Pediatric Cardiology, University of Utah, 81 N. Mario Capecchi Drive, Salt Lake City, UT84113, USA. Tel: 801 662 1000. E-mail: megan.blaney@hsc.utah.edu

Abstract

Objectives:

To compare patients treated for incomplete Kawasaki disease whose practitioners followed versus did not follow American Heart Association criteria and to evaluate the association of cardiology consultation with adherence to these guidelines.

Study design:

Single centre retrospective cohort study of patients <18 years old who received ≥1 dose of intravenous immunoglobulin for Kawasaki disease between 01/2006 and 01/2018. We collected demographics, clinical and laboratory data, coronary artery abnormalities, and cardiology consultation status. Patients treated for incomplete Kawasaki disease were divided into two groups based on adherence versus nonadherence to American Heart Association guidelines and compared by Wilcoxon rank sum test and chi-squared or Fisher’s exact test.

Results:

Of the 357 patients treated for Kawasaki disease, 109 (31%) were classified as incomplete Kawasaki disease. The American Heart Association algorithm for identifying patients with incomplete Kawasaki disease was followed in 81/109 (74%). Coronary artery abnormalities were present in 46/109 (42%) of the patients who were treated for incomplete Kawasaki disease. Cardiology consultation was more frequent in those fulfilling American Heart Association criteria for the diagnosis of incomplete Kawasaki disease versus those who did not fulfill criteria (76% versus 48%, p = 0.005).

Conclusions:

Over 25% of patients treated for incomplete Kawasaki disease did not meet American Heart Association guidelines. Guidelines were more frequently followed when the paediatric cardiology team was consulted. Consulting physicians with experience and expertise in the evaluation and management of incomplete KD should be strongly considered in the care of these patients.

Type
Original Article
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

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