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Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass

Published online by Cambridge University Press:  10 October 2013

Costan G. Magnussen*
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Terence Dwyer
Murdoch Childrens Research Institute, Melbourne, Australia
Alison Venn
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
Correspondence to: Dr C. G. Magnussen, Menzies Research Institute Tasmania, University of Tasmania, MS2 17 Liverpool St, Hobart 7000, Tasmania, Australia. Tel: +61 3 6226 7762; Fax: +61 3 6226 7704; E-mail:


In a prospective cohort of 181 individuals followed up since childhood – when aged 9, 12 and 15 years – patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood – at mean age of 31 years – compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m2.7, p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=−0.03, p=0.75; pdiff=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; pdiff=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.

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Copyright © Cambridge University Press 2013 

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