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Effects of chronic treprostinil treatment on experimental right heart hypertrophy and failure

Published online by Cambridge University Press:  18 April 2016

Sofie Axelgaard
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Sarah Holmboe
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Steffen Ringgaard
The MR Centre, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Thomas K. Hillgaard
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Stine Andersen
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Mona S. Hansen
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Asger Andersen
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Jens E. Nielsen-Kudsk*
Department of Cardiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Correspondence to: J. E. Nielsen-Kudsk, MD, DMSc, Department of Cardiology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200 Aarhus N, Denmark. Tel: +45 7845 2024; Fax: +45 7845 2117; E-mail:



Right heart function is an important predictor of morbidity and mortality in pulmonary arterial hypertension and many CHD. We investigated whether treatment with the prostacyclin analogue treprostinil could prevent pressure overload-induced right ventricular hypertrophy and failure.


Male Wistar rats were randomised to severe pulmonary trunk banding with a 0.5-mm banding clip (n=41), moderate pulmonary trunk banding with a 0.6-mm banding clip (n=36), or sham procedure (n=10). The banded rats were randomised to 6 weeks of treatment with a moderate dose of treprostinil (300 ng/kg/minute), a high dose of treprostinil (900 ng/kg/minute), or vehicle.


Pulmonary trunk banding effectively induced hypertrophy, dilatation, and decreased right ventricular function. The severely banded animals presented with decompensated heart failure with extracardial manifestations. Treatment with treprostinil neither reduced right ventricular hypertrophy nor improved right ventricular function.


In the pulmonary trunk banding model of pressure overload-induced right ventricular hypertrophy and failure, moderate- and high-dose treatment with treprostinil did not improve right ventricular function neither in compensated nor in decompensated right heart failure.

Original Articles
© Cambridge University Press 2016 

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