Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-18T15:00:43.117Z Has data issue: false hasContentIssue false
  • English
  • Français

Compliance with aspirin in paediatric CHD post-percutaneous transcatheter occlusion: a cross-sectional study

Published online by Cambridge University Press:  03 September 2020

Qing-Qing Song Open the ORCID record for Qing-Qing Song [Opens in a new window] ,
Li-Hui Zhu ,
Ou-Ying Chen ,
Zhi-Rong Xiao ,
Zhi Chen ,
Yun-Bin Xiao ,
Jian-Chao Meng ,
Chao Zuo  and
Jos M. Latour
Qing-Qing Song
Affiliation:
Department of Cardiology, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Li-Hui Zhu*
Affiliation:
Department of Nursing, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Ou-Ying Chen
Affiliation:
Department of Nursing, Hunan University of Chinese Medicine, Changsha, Hunan Province, People’s Republic of China
Zhi-Rong Xiao
Affiliation:
Department of Cardiology, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Zhi Chen
Affiliation:
Department of Cardiology, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Yun-Bin Xiao
Affiliation:
Department of Cardiology, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Jian-Chao Meng
Affiliation:
Department of Cardiology, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Chao Zuo
Affiliation:
Department of Cardiology, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China
Jos M. Latour
Affiliation:
Department of Nursing, Hunan Children’s Hospital, Changsha, Hunan Province, People’s Republic of China School of Nursing and Midwifery, Faculty of Health, University of Plymouth, Plymouth, UK
*
Author for correspondence: Li-Hui Zhu, Nursing Department, Hunan Children’s Hospital, No. 82 Ziyuan Road, Changsha41007, Hunan Province, People’s Republic of China. Tel: +8613548578258; Fax: +8673185356666. E-mail: 877845375@qq.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Predictors of compliance with aspirin in children following cardiac catheterisation have not been identified. The aim of this study is to identify the caregivers’ knowledge, compliance with aspirin medication, and predictors of compliance with aspirin in children with Congenital Heart Disease (CHD) post-percutaneous transcatheter occlusion.

Methods:

A cross-sectional explorative design was adopted using a self-administered questionnaire and conducted between May 2017 and May 2018. Recruited were 220 caregivers of children with CHD post-percutaneous transcatheter occlusion. Questionnaires included child and caregivers’ characteristics, a self-designed and tested knowledge about aspirin scale (scoring scale 0–2), and the 8-item Morisky Medication Adherence Scale (scoring scale 0–8). Data were analysed using multivariate binary logistic regression analysis to identify predictors of compliance with aspirin.

Results:

Of the 220 eligible children and caregivers, 210 (95.5%) responded and 209 surveys were included in the analysis. The mean score of knowledge was 7.25 (standard deviation 2.27). The mean score of compliance was 5.65 (standard deviation 1.36). Child’s age, length of aspirin use, health insurance policies, relationship to child, monthly income, and knowledge about aspirin of caregivers were independent predictors of compliance with aspirin (p < 0.05).

Conclusion:

Caregivers of children with CHD had an adequate level of knowledge about aspirin. Compliance to aspirin medication reported by caregivers was low. Predictors of medium to high compliance with aspirin were related to the child’s age and socio-economic reasons. Further studies are needed to identify effective strategies to improve knowledge, compliance with medication, and long-term outcomes of children with CHD.

Keywords

CHDmedicationadherencecatheterisationaspirinchildren
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 10 , October 2020 , pp. 1462 - 1468
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Calcagni, G, Unolt, M, Digilio, MC, et al. Congenital heart disease and genetic syndromes: new insights into molecular mechanisms. Expert Rev Mol Diagn 2017; 17: 861–870.CrossRefGoogle ScholarPubMed
Hoffman, JI. Congenital heart disease: incidence and inheritance. Pediatr Clin North Am 1990; 37: 25–43.CrossRefGoogle ScholarPubMed
Methlouthi, J, Mahdhaoui, N, Bellaleh, M, et al. Incidence of congenital heart disease in newborns after pulse oximetry screening introduction. La Tunisie Medicale 2016; 94: 231–234.Google ScholarPubMed
Ladak, LA, Hasan, BS, Gullick, J, Gallagher, R. Health-related quality of life in congenital heart disease surgery in children and young adults: a systematic review and meta-analysis. Arch Dis Child 2019; 104: 340–347.CrossRefGoogle Scholar
McClung, N, Glidewell, J, Farr, SL. Financial burdens and mental health needs in families of children with congenital heart disease. Congenit Heart Dis 2018; 13: 554–562.CrossRefGoogle ScholarPubMed
Wernovsky, G, Licht, DJ. Neurodevelopmental outcomes in children with congenital heart disease-what can we impact? Pediatr Crit Care Med 2016; 17: S232–S242.CrossRefGoogle ScholarPubMed
Serinelli, S, Arunkumar, P, White, S. Undiagnosed congenital heart defects as a cause of sudden, unexpected death in children. J Forensic Sci 2018; 63: 1750–1755.CrossRefGoogle ScholarPubMed
Abdulkadir, M, Abdulkadir, Z. A systematic review of trends and patterns of congenital heart disease in children in Nigeria from 1964–2015. Afr Health Sci 2016; 16: 367–377.CrossRefGoogle Scholar
Zhao, QM. Implementation and Application Study of Newborn Screening Approach for Congenital Heart Disease in China [Doctor of Philosophy], Fudan University; 2013.Google Scholar
Rahkonen, OP, Lee, KJ, Chaturvedi, RC, Benson, LN. The first ten of everything: a review of past and current practice in pediatric cardiac percutaneous interventions. Congenit Heart Dis 2015; 10: 292–301.CrossRefGoogle ScholarPubMed
Cinteza, EE, Butera, G. Complex ventricular septal defects. Update on percutaneous closure. Rom J Morphol Embryol 2016; 57: 1195–1205.Google ScholarPubMed
Jang, SI. Procedural, early and long-term outcomes after percutaneous closure of atrial septal defect: comparison between large and very large atrial septal defect groups. Korean Circ J 2019; 49: 987–989.CrossRefGoogle Scholar
Pan, G, Xie, ZF, Zhang, Y, Long, SC, Xu, XP, Zhang, ZW. Platelet activation through the efficacy of aspirin in congenital heart disease patients undergoing transcatheter closure of atrial septal defects or ventricular septal defects. Genet Test Mol Biomarkers 2014; 18: 832–838.CrossRefGoogle ScholarPubMed
Orford, JL, Berger, PB. Modulating thrombotic potential in catheter-based percutaneous coronary and peripheral vascular interventions. J Thromb Thrombolysis 2004; 17: 11–20.CrossRefGoogle ScholarPubMed
Feltes, TF, Bacha, E, Beekman, RH, et al. Indications for cardiac catheterization and intervention in pediatric cardiac disease: a scientific statement from the American Heart Association. Circulation 2011; 123: 2607–2652.CrossRefGoogle ScholarPubMed
Krumsdorf, U, Ostermayer, S, Billinger, K, et al. Incidence and clinical course of thrombus formation on atrial septal defect and patient foramen ovale closure devices in 1,000 consecutive patients. J Am Coll Cardiol 2004; 43: 302–309.CrossRefGoogle ScholarPubMed
Bartakian, S, El-Said, HG, Printz, B, Moore, JW. Prospective randomized trial of transthoracic echocardiography versus transesophageal echocardiography for assessment and guidance of transcatheter closure of atrial septal defects in children using the Amplatzer septal occluder. JACC Cardiovasc Interv 2013; 6: 974–980.CrossRefGoogle ScholarPubMed
Du, ZD, Hijazi, ZM, Kleinman, CS, Silverman, NH, Larntz, K. Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults: results of a multicenter nonrandomized trial. J Am Coll Cardiol 2002; 39: 1836–1844.CrossRefGoogle ScholarPubMed
Tomar, M, Khatri, S, Radhakrishnan, S, Shrivastava, S. Intermediate and long-term follow up of percutaneous device closure of fossa ovalis atrial septal defect by the Amplatzer septal occluder in a cohort of 529 patients. Ann Pediatr Cardiol 2011; 4: 22–27.CrossRefGoogle Scholar
Vandenbroucke, JP, von Elm, E, Altman, DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Ann Intern Med 2007; 147: W163–194.CrossRefGoogle ScholarPubMed
van der Wurff, ISM, Meyer, BJ, de Groot, RHM. A review of recruitment, adherence and drop-out rates in omega-3 polyunsaturated fatty acid supplementation trials in children and adolescents. Nutrients 2017; 9: E474.CrossRefGoogle ScholarPubMed
Morisky, DE, Ang, A, Krousel-Wood, M, Ward, HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich) 2008; 10: 348–354.CrossRefGoogle Scholar
Ho, CP, Lee, TJF. The reliability and validity of the Chinese version of the eight-item Morisky medication adherence scale. Value Health 2014; 17: A730.CrossRefGoogle ScholarPubMed
Janezic, A, Locatelli, I, Kos, M. Criterion validity of 8-item Morisky Medication Adherence Scale in patients with asthma. PloS One 2017; 12: e0187835.CrossRefGoogle ScholarPubMed
Duffy, D, Kelly, E, Trang, A, Whellan, D, Mills, G. Aspirin for cardioprotection and strategies to improve patient adherence. Postgrad Med 2014; 126: 18–28.CrossRefGoogle ScholarPubMed
Lee, JL, Eaton, CK, Loiselle Rich, K, et al. The interactive effect of parent personality and medication knowledge on adherence in children awaiting solid organ transplantation. Health Psychol 2017; 36: 445–448.CrossRefGoogle ScholarPubMed
Basharat, S, Jabeen, U, Zeeshan, F, Bano, I, Bari, A, Rathore, AW. Adherence to asthma treatment and their association with asthma control in children. J Pak Med Assoc 2018; 68: 725–728.Google ScholarPubMed
Thornburg, CD, Calatroni, A, Telen, M, Kemper, AR. Adherence to hydroxyurea therapy in children with sickle cell anemia. J Pediatr 2010; 156: 415–419.CrossRefGoogle ScholarPubMed
Pye, S, Green, A. Parent education after newborn congenital heart surgery. Adv Neonatal Care 2003; 3: 147–156.CrossRefGoogle ScholarPubMed
Tregay, J, Wray, J, Crowe, S, et al. Going home after infant cardiac surgery: a UK qualitative study. Arch Dis Child 2016; 101: 320–325.CrossRefGoogle ScholarPubMed
Hester, C, Park, C, Chung, J, Balkrishnan, R, Feldman, S, Chang, J. Medication adherence in children and adolescents with acne vulgaris in Medicaid: a retrospective study analysis. Pediatr Dermatol 2016; 33: 49–55.CrossRefGoogle ScholarPubMed
Mickley, KL, Burkhart, PV, Sigler, AN. Promoting normal development and self-efficacy in school-age children managing chronic conditions. Nurs Clin North Am 2013; 48: 319–328.CrossRefGoogle ScholarPubMed
Bushnell, GA, Brookhart, MA, Gaynes, BN, Compton, SN, Dusetzina, SB, Sturmer, T. Examining parental medication adherence as a predictor of child medication adherence in pediatric anxiety disorders. Med Care 2018; 56: 510–519.CrossRefGoogle ScholarPubMed
Yang, C, Hao, Z, Yu, D, Xu, Q, Zhang, L. The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: a systematic review and meta analysis. Epilepsy Res 2018; 142: 88–99.CrossRefGoogle ScholarPubMed