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Analysis of the influencing factors associated with dyssynchrony and cardiac dysfunction in children with ventricular pre-excitation

Published online by Cambridge University Press:  16 June 2022

Yi Zhang Open the ORCID record for Yi Zhang [Opens in a new window] ,
Xiao-mei Li Open the ORCID record for Xiao-mei Li [Opens in a new window] ,
Jian Cui ,
He Jiang ,
Jing-hao Li Open the ORCID record for Jing-hao Li [Opens in a new window]  and
Mei-ting Li
Yi Zhang
Affiliation:
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, People’s Republic of China
Xiao-mei Li*
Affiliation:
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, People’s Republic of China
Jian Cui
Affiliation:
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, People’s Republic of China
He Jiang
Affiliation:
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, People’s Republic of China
Jing-hao Li
Affiliation:
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, People’s Republic of China
Mei-ting Li
Affiliation:
Department of Pediatric Cardiology, Heart Center, First Hospital of Tsinghua University (Beijing Huaxin Hospital), Beijing, People’s Republic of China
*
Author for correspondence: Xiao-mei Li, Department of Pediatric Cardiology, Heart Center, the First Hospital of Tsinghua University (Beijing Huaxin Hospital), No.6 Jiuxianqiao 1st Road, Chaoyang District, Beijing 100016, People’s Republic of China. Tel: 00-86-13910847672; Fax: 00-86-010-64308260. E-mail: lixiaomei1368@sina.com
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Abstract

Objective:

To investigate the correlation between ventricular pre-excitation-related dyssynchrony, on cardiac dysfunction, and recovery.

Methods and Results:

This study included 76 children (39 boys and 37 girls) with a median age of 5.25 (2.67–10.75) years. The patients with pre-excitation-related cardiac dysfunction (cardiac dysfunction group, n = 34) had a longer standard deviation of the time-to-peak systolic strain of the left ventricle and larger difference between the maximum and minimum times-to-peak systolic strain than those with a normal cardiac function (normal function group, n = 42) (51.77 ± 24.70 ms versus 33.29 ± 9.48 ms, p < 0.05; 185.82 ± 92.51 ms versus 111.93 ± 34.27 ms, p < 0.05, respectively). The cardiac dysfunction group had a maximum time-to-peak systolic strain at the basal segments of the anterior and posterior septa and the normal function group at the basal segments of anterolateral and posterolateral walls. The prevalence of ventricular septal dyssynchrony in the cardiac dysfunction group was significantly higher than that in the normal function group (94.1% (32/34) versus 7.7% (3/42), p < 0.05). The patients with ventricular septal dyssynchrony (n = 35) had a significantly higher prevalence of intra-left ventricular systolic dyssynchrony than those with ventricular septal synchrony (n = 41) (57.1% (20/35) versus 14.6% (6/41), p < 0.05). During follow-up after pathway ablation, the patients who recovered from intra-left ventricular dyssynchrony (n = 29) had a shorter left ventricular ejection fraction recovery time than those who did not (n = 5) (χ2 = 5.94, p < 0.05). Among the patients who recovered, 93.1% (27/29) had a normalised standard deviation of the time-to-peak systolic strain and difference between the maximum and minimum times-to-peak systolic strain within 1 month after ablation.

Conclusion:

Ventricular pre-excitation may cause ventricular septal dyssynchrony; thus, attention must be paid to intra-left ventricular dyssynchrony and cardiac dysfunction. Whether intra-left ventricular systolic dyssynchrony can resolve within 1 month may be a new early predictor of patient prognosis.

Keywords

Ventricular pre-excitationdilated cardiomyopathychildrenspeckle-tracking technologyventricular dyssynchrony
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 5 , May 2023 , pp. 771 - 779
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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