Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-24T19:50:29.270Z Has data issue: false hasContentIssue false
  • English
  • Français

Prevalence of Lifestyle Risk Factors in Myotonic Dystrophy Type 1

Published online by Cambridge University Press:  23 September 2014

Cynthia Gagnon ,
Maud-Christine Chouinard ,
Luc Laberge ,
Diane Brisson ,
Daniel Gaudet ,
Mélissa Lavoie ,
Nadine Leclerc  and
Jean Mathieu
Cynthia Gagnon*
Affiliation:
Faculty of Medicine and Health Sciences, Université de Sherbrooke Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Neuromuscular Clinic, Centre de réadaptation en déficience physique de Jonquière, Centre de santé et de services sociaux de Jonquière
Maud-Christine Chouinard
Affiliation:
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Neuromuscular Clinic, Centre de réadaptation en déficience physique de Jonquière, Centre de santé et de services sociaux de Jonquière Health Science department, Université du Québec à Chicoutimi, Québec, Canada
Luc Laberge
Affiliation:
ÉCOBES Recherche et transfert, Cégep de Jonquière Health Science department, Université du Québec à Chicoutimi, Québec, Canada
Diane Brisson
Affiliation:
University of Montreal Community Genomic Medicine Center, Department of medicine, Université de Montréal
Daniel Gaudet
Affiliation:
University of Montreal Community Genomic Medicine Center, Department of medicine, Université de Montréal
Mélissa Lavoie
Affiliation:
Faculty of Medicine and Health Sciences, Université de Sherbrooke Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Neuromuscular Clinic, Centre de réadaptation en déficience physique de Jonquière, Centre de santé et de services sociaux de Jonquière
Nadine Leclerc
Affiliation:
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Neuromuscular Clinic, Centre de réadaptation en déficience physique de Jonquière, Centre de santé et de services sociaux de Jonquière
Jean Mathieu
Affiliation:
Faculty of Medicine and Health Sciences, Université de Sherbrooke Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Neuromuscular Clinic, Centre de réadaptation en déficience physique de Jonquière, Centre de santé et de services sociaux de Jonquière
*
Faculty of Medicine and Health Sciences, Université de Sherbrooke, Centre de santé et de services sociaux de Jonquière, 2230 de l'Hôpital, C.P. 1200, Jonquière, Québec G7X 7X2, Canada Email: cynthia.gagnon4@usherbrooke.ca
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background:

The prevalence of unhealthy lifestyle habits such as smoking has seldom been described in neuromuscular disorders, including myotonic dystrophy type 1 (DM1). However, it is essential to document the unhealthy lifestyle habits as they can exacerbate existing impairments and disabilities. The objectives are: 1) To determine the prevalence of risk factors among individuals with DM1; 2) To compare the prevalence among classic and mild phenotypes.

Method:

A survey was done on a sample of two-hundred (200) patients with DM1 as part of a larger study. Lifestyle risk factors included being overweight or obese, tobacco smoking, illicit drug use, excessive alcohol consumption and physical inactivity. A registered nurse administered the validated public health survey. Categorization of risk factors were based on national standards and compared with provincial and regional prevalences.

Results:

50% of DM1 patients were overweight or obese, 23.6% were regular smokers, and 76% were physically inactive. Except for overweight and obesity, significant differences were observed between patients with classic and mild phenotypes for all the other lifestyle risk factors: those with the classic phenotype being more often regular smokers, consuming more often illicit drugs and being less physically active.

Conclusions:

The results of this study will provide guidance for the development of better adapted and focussed health promotion interventions in the future.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 1 , January 2013 , pp. 42 - 47
Copyright
Copyright © The Canadian Journal of Neurological 2013

References

1. Emery, AE. Population frequencies of inherited neuromuscular diseases: a world survey. Neuromuscul Disord. 1991;1(1):19–29.Google Scholar
2. Mathieu, J, De Braekeleer, M, Prévost, C. Genealogical reconstruction of myotonic dystrophy in the Saguenay-Lac-Saint-Jean area (Quebec, Canada). Neurology. 1990 May;40(5):839–42.Google Scholar
3. Fu, YH, Pizzuti, A, Fenwick, RG Jr., et al. An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science (New York, NY. 1992 Mar 6;255(5049):1256–8.Google Scholar
4. Harper, P. Myotonic dystrophy: a multisystemic disorder. In: Harper, P, Van Engelen, B, Eymard, B, Wilcox, D, editors. Myotonic Dystrophy: present management, future therapy. Oxford: Oxford University Press; 2004. p. 3–13.Google Scholar
5. Mathieu, J, Boivin, H, Richards, CL. Quantitative motor assessment in myotonic dystrophy. Can J Neurol Sci. 2003 May;30(2):129–36.Google Scholar
6. Laberge, L, Begin, P, Richer, L, Jean, S, Mathieu, J. Fatigue and daytime sleepiness in patients with myotonic dystrophy type 1: to lump or split? Neuromuscul Disord. 2009;19(6):397–402.Google Scholar
7. Meola, G, Sansone, V, Perani, D, et al. Executive dysfunction and avoidant personality trait in myotonic dystrophy type 1 (DM-1) and in proximal myotonic myopathy (PROMM/DM-2). Neuromuscul Disord. 2003 Dec;13(10):813–21.Google Scholar
8. Antonini, G, Soscia, F, Giubilei, F, et al. Health-related quality of life in myotonic dystrophy type 1 and its relationship with cognitive and emotional functioning. J Rehabil Med. 2006 May;38(3):181–5.Google Scholar
9. Gagnon, C, Mathieu, J, Jean, S, et al. Predictors of disrupted social participation in myotonic dystrophy type 1. Arch Phys Med Rehabil. 2008;89(7):1246–55.CrossRefGoogle ScholarPubMed
10. Gagnon, C, Mathieu, J, Noreau, L. Life habits in myotonic dystrophy type 1. J Rehabil Med. 2007 Sep;39(7):560–6.CrossRefGoogle ScholarPubMed
11. Gagnon, C, Noreau, L, Moxley, RT, et al. Towards an integrative approach to the management of myotonic dystrophy type 1. J Neurol Neurosurg Psychiatry. 2007 Aug;78(8):800–6.Google Scholar
12. Laberge, L, Veillette, S, Mathieu, J, Auclair, J, Perron, M. The correlation of CTG repeat length with material and social deprivation in myotonic dystrophy. Clin Genet. 2007 Jan;71(1):59–66.CrossRefGoogle ScholarPubMed
13. Perron, M, Veillette, S, Mathieu, J. [Myotonic dystrophy: I. Socioeconomic and residential characteristics of the patients]. Can J Neurol Sci. 1989;16(1):109–13.CrossRefGoogle ScholarPubMed
14. Gagnon, C, Chouinard, MC, Jean, S, et al. Health supervision and anticipatory guidance in adult myotonic dystrophy type 1. Neuromuscul Disord. 2010 July 7;20(12):847–51.Google Scholar
15. Stuifbergen, AK, Rogers, S. Health promotion: an essential component of rehabilitation for persons with chronic disabling conditions. ANS Adv Nurs Sci. 1997 Jun;19(4):1–20.Google Scholar
16. Gagnon, C, Chouinard, M, Lavoie, M, Champagne, F. Analyse du rôle de l’infirmière dans le suivi des personnes atteintes de maladies neuromusculaires. Can J Neurosci Nurs. 2010;32(4):22–30.Google Scholar
17. World Health Organization. Ottawa Charter for Health Promotion. Health Promotion. 1986;1(4):iii–v.Google Scholar
18. Pender, NJ. Health Promotion in Nursing Practice. 2nd ed. Stamford: Appleton & Lange; 1987.Google Scholar
19. Stuifbergen, AK, Seraphine, A, Harrison, T, Adachi, E. An explanatory model of health promotion and quality of life for persons with post-polio syndrome. Soc Sci Med. 2005 Jan;60(2):383–93.Google Scholar
20. Harrisson, T. Health promotion for persons with disabilities: What does litterature reveal? Fam Community Health. 2006;29(1S):12s–9s.Google Scholar
21. Stuifbergen, AK. Building health promotion interventions for persons with chronic disabling conditions. Fam Community Health. 2006 Jan-Mar;29(1 Suppl):28S–34S.CrossRefGoogle ScholarPubMed
22. Stuifbergen, AK, Becker, H, Blozis, S, Timmerman, G, Kullberg, V. A randomized clinical trial of a wellness intervention for women with multiple sclerosis. Arch Phys Med Rehabil. 2003 Apr;84(4):467–76.Google Scholar
23. Wilkinson, R, Marmot, M. Social determinants of health: the solid facts. 2nd ed. Copenhagen (Denmark): World Health Organization; 2003.Google Scholar
24. Aitkens, S, Kilmer, DD, Wright, NC, McCrory MA. Metabolic syndrome in neuromuscular disease. Arch Phys Med Rehabil. 2005 May;86(5):1030–6.Google Scholar
25. Koch, MC, Grimm, T, Harley, HG, Harper, PS. Genetic risks for children of women with myotonic dystrophy. Am J Hum Genet. 1991 Jun;48(6):1084–91.Google Scholar
26. Mathieu, J, Boivin, H, Meunier, D, Gaudreault, M, Begin, P. Assessment of a disease-specific muscular impairment rating scale in myotonic dystrophy. Neurology. 2001 Feb 13;56(3):336–40.CrossRefGoogle ScholarPubMed
27. Direction Santé Québec. Enquěte générale sur la santé et le bienětre de la population. Québec: Institut de la statistique du Québec; 1998.Google Scholar
28. Direction Santé Québec. L’Enquěte québécoise sur les limitations d’activités 1998 Québec: Institut de la statistique du Québec; 1998.Google Scholar
29. Educalcool. Les niveaux de consommation d’alcool à faible risque 2-3-4-5-0. Montréal: Educalcool; 2007.Google Scholar
30. Santé Canada. Canadian guidelines for body weight classification in adults. Ottawa; 2003.Google Scholar
31. Bergeron, A, Clouston, M-C, Couture, R, Duplain, M, Lapierre, R. Enquěte de santé du Saguenay-Lac-St-Jean 2007 – Rapport sommaire. Saguenay: Direction de la santé publique, Agence de santé et de services sociaux du Saguenay-Lac-St-Jean; 2007.Google Scholar
32. Motlagh, B, MacDonald, JR, Tarnopolsky, MA. Nutritional inadequacy in adults with muscular dystrophy. Muscle Nerve. 2005 Jun;31(6):713–8.Google Scholar
33. Despres, JP. Cardiovascular disease under the influence of excess visceral fat. Crit Path Cardiol. 2007 Jun;6(2):51–9.CrossRefGoogle ScholarPubMed
34. Brisson, D, Houde, G, St-Pierre, J, Vohl, MC, Mathieu, J, Gaudet, D. The pleiotropic expression of the myotonic dystrophy protein kinase gene illustrates the complex relationships between genetic, biological and clinical covariates of male aging. Aging Male. 2002 Dec;5(4):223–32.Google Scholar
35. McCrory, MA, Wright, NC, Kilmer, DD. Nutritional aspects of neuromuscular diseases. Phys Med Rehabil Clin N Am. 1998 Feb;9(1):127–43.Google Scholar
36. Drewnowski, A, Specter, S. Poverty and obesity: the role of energy density and energy costs. Am J Clin Nutr. 2004;79(1):6–16.CrossRefGoogle ScholarPubMed
37. Kilmer, DD, Wright, NC, Aitkens, S. Impact of a home-based activity and dietary intervention in people with slowly progressive neuromuscular diseases. Arch Phys Med Rehabil. 2005 Nov;86 (11):2150–6.CrossRefGoogle ScholarPubMed
38. Mathieu, J, Allard, P, Potvin, L, Prévost C, Bégin P. A 10-year study of mortality in a cohort of patients with myotonic dystrophy. Neurology. 1999 May 12;52(8):1658–62.CrossRefGoogle Scholar
39. Gagnon, C, Mathieu, J, Noreau, L. Measurement of participation in myotonic dystrophy: reliability of the LIFE-H. Neuromuscul Disord. 2006 Apr;16(4):262–8.Google Scholar
40. Laberge, L, Begin, P, Dauvilliers, Y, et al. A polysomnographic study of daytime sleepiness in myotonic dystrophy type 1. J Neurol Neurosurg Psychiatry. 2009 February 11, 2009;80(6):642–6.Google Scholar
41. Cup, EH, Pieterse, AJ, ten Broek-Pastoor, JM, et al. Exercise therapy and other types of physical therapy for patients with neuromuscular diseases: a systematic review. Arch Phys Med Rehabil. 2007 Nov;88(11):1452–64.Google Scholar
42. Cup, EH, Pieterse, AJ, Knuijt, S, et al. Referral of patients with neuromuscular disease to occupational therapy, physical therapy and speech therapy: usual practice versus multidisciplinary advice. Disabil Rehabil. 2007 May 15;29(9):717–26.Google Scholar
43. Eagle, M. Report on the muscular dystrophy campaign workshop: exercise in neuromuscular diseases Newcastle, January 2002. Neuromuscul Disord. 2002 Dec;12(10):975–83.Google Scholar
44. Voet, NBM, van der Kooi, EL, Riphagen, II, Lindeman, E, van Engelen, BGM, Geurts, ACH. Strength training and aerobic exercise training for muscle disease. Cochrane Database Syst Rev. 2010 January 20(1):CD003907.Google Scholar
45. Régie régionale de la santé et des services sociaux du Saguenay-Lac-St-Jean. Tableau synoptique des indicateurs socio-sanitaires par territoire: Le Québec, le Saguenay-Lac-St-Jean et ses territoires de CLSC. Chicoutimi: Direction de la santé publique, Régie régionale de la santé et des services sociaux du Saguenay-Lac-St-Jean,; 2003.Google Scholar
46. Comité permanent sur la toxicomanie. Le point sur la situation de la toxicomanie au Québec en l’an 2000 Montréal: Ministère de la Santé et des Services Sociaux; 2000.Google Scholar
47. Galobardes, B, Costanza, MC, Bernstein, MS, Delhumeau, CH, Morabia, A. Trends in risk factors for the major “lifestyle-related diseases” in Geneva, Switzerland, 1993–2000. Ann Epidemiol. 2003 Aug;13(7):537–40.Google Scholar
48. Perron, M, Veillette, S, Mathieu, J. La dystrophie myotonique: I. Caractéristiques socio-économiques et résidentielles des malades. Can J Neurol Sci. 1989 Feb;16(1):109–13.Google Scholar