Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-24T04:03:43.830Z Has data issue: false hasContentIssue false
  • English
  • Français

Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy and Skin Changes (Poems) Syndrome

Published online by Cambridge University Press:  18 September 2015

I. Milanov  and
D. Georgiev
I. Milanov*
Affiliation:
University Hospital IV kilometer, III Neurological Clinic, Sofia
D. Georgiev
Affiliation:
University Hospital IV kilometer, III Neurological Clinic, Sofia
*
Medical University Hospital-IV kilometer, III Neurological Clinic, Blvd. Tzarigradsko shosse - IV kilometer, Sofia 1113, Bulgaria
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A patient with a three year history of POEMS syndrome-polyneuropathy, hepatosplenomegaly M-protein, skin changes, optic disc edema, peripheral oedema, pleuritis, lymphadenopathy, and osteosclerotic myeloma is described. The patient had a twenty year history of psoriasis and impotence was the first sign of the disease. The pathophysiology of this multisystem disorder is unknown, although the M-protein is essential. No improvement was found after radiation, chemotherapy and steroid treatment.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue 1 , February 1994 , pp. 60 - 63
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

References

REFERENCES

1.Bardwick, PA, Zvaifler, NJ, Gill, GN, et al. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes - the POEMS syndrome: report on cases and a review of the literature. Medicine 1980; 59: 311–322.CrossRefGoogle Scholar
2.Nakanishi, T, Sobue, I, Toyokura, Y, et al. The Crow-Fukase syn- drome: a study of 102 cases in Japan. Neurology 1984; 34: 712–720.CrossRefGoogle Scholar
3.Boiling, JP, Brazis, PW. Optic disk swelling with peripheral neu-ropathy, organomegaly, endocrinopathy, monoclonal gammopa-thy, and skin changes (POEMS syndrome). Am J Ophthalmol 1990; 109: 503–510.CrossRefGoogle Scholar
4.Bourdette, DN, Rosenberg, NL. Infiltrative orbitopathy, optic disk edema, and POEMS. Neurology (Clev) 1984; 34: 532–533.CrossRefGoogle ScholarPubMed
5.Resnick, D, Greenway, GD, Bardwick, PA, et al. Plasma cell dyscra-sia with polyneuropathy, organomegaly, endocrinopathy, m-pro-tein, and skin changes: the POEMS syndrome: distinctive radiographic abnormalities. Radiology 1981; 140: 17–;22.CrossRefGoogle ScholarPubMed
6.Iwashita, H, Ohnishi, A, Asada, M, Kanazawa, Y, Juroiwa, Y. Polyneuropathy, skin hyperpigmentation, edema and hyper-trychosis in localised osteosclerotic myeloma. Neurology 1977; 27: 675–681.CrossRefGoogle ScholarPubMed
7.Kelly, JJ, Kyle, RA, Miles, JM, O’Brein, PC, Dyck, PJ. The spectrum of peripheral neuropathy in myeloma. Neurology 1981; 31: 31–34.CrossRefGoogle ScholarPubMed
8.Kelly, JJ, Kyle, RA, Miles, JM, Dyck, PJ. Osteosclerotic myeloma and peripheral neuropathy. Neurology 1983; 33: 202–210.Google ScholarPubMed
9.Waldenstorm, JG, Adner, A, Gydell, K, Zettervall, O. Osteosclerotic-plasmocytoma- with polyneuropathy, hypertrichosis, and diabetes. Acta Med Scand 1978; 203: 297–303.Google Scholar
10.Driedger, H, Pruzanski, W. Plasma cell neoplasia with peripheral polyneuropathy: a study of five cases and a review of the literature. Medicine (Baltimore) 1980; 59: 301–310.CrossRefGoogle Scholar
11.Libeert, P, Van Hoof, A, Louwagie, A, Marchau, M, Dehaene, I. The POEMS-syndrome: an unusual form of plasma cell dyscrasia. Acta Clin Belg 1987; 42: 188–192.CrossRefGoogle ScholarPubMed
12.Reitan, JB, Pape, E, Fossa, SD, et al. Osteosclerotic myeloma with polyneuropathy. Acta Med Scand 1980; 208: 137–144.CrossRefGoogle ScholarPubMed
13.Vidakovic, A, Simic, P, Stojisavljevic, N, et al. Polyneuropathy with osteosclerotic myeloma-POEMS syndrome. Neurology 1992; 239: 49–52.CrossRefGoogle ScholarPubMed
14.Miralles, GD, O’Fallon, JR, Talley, NJ. Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome.? Engl J Med 1992; 327: 1919–1923.CrossRefGoogle ScholarPubMed
15.Lach, B, Rippstein, P, Atack, D, Afar, DEH, Gregor, A. Immunoelectron microscopic localization of monoclonal IgM antibodies in gammopathy associated with peripheral demyelina-tive neuropathy. Acta Neuropathol 1993; 85: 298–307.CrossRefGoogle ScholarPubMed
16.Monaco, S, Bonetti, B, Ferrari, S, et al. Complement-mediated demyeiination in patients with IgM monoclonal gammopathy and polyneuropathy. ? Engl J Med 1990; 322: 649–652.CrossRefGoogle ScholarPubMed
17.Reulecke, M, Dumas, M, Meier, C. Specific antibody activity against neuroendocrine tissue in a case of POEMS syndrome with IgG gammopathy. Neurology 1988; 38: 614–616.CrossRefGoogle Scholar
18.Matsumine, H. Accelerated conversion of androgen to estrogen in plasma cell dyscrasia associated with polyneuropathy, anasarca, and skin pigmentation. Engl J Med 1985; 313: 1025–1026.Google ScholarPubMed
19.Shelly, WB, Shelly, ED. The skin changes in the Crow-Fukase (POEMS) syndrome. Arch Dermatol 1987; 123: 85–87.CrossRefGoogle Scholar
20.Ishikawa, O, Nihei, I, Ishikawa, H. The skin changes of POEMS syn-drome. Br J Dermatol 1987; 117: 523–526.CrossRefGoogle Scholar
21.Kanitakis, J, Roger, H, Soubrier, M, Dubost, JJ, Chouvet, B, Souteyrand, P. Cutaneous angiomas in POEMS syndrome. Arch Dermatol 1988; 124: 695–698.CrossRefGoogle ScholarPubMed
22.Trentham, DE, Masi, AT, Marker, HW. Polyneuropathy and anasarca: evidence for a new connective-tissue syndrome and vasculo-pathic contribution. Ann Intern Med 1976; 84: 271–274.CrossRefGoogle ScholarPubMed
23.Dyck, PJ, Low, PA, Windebank, AJ, et al. Plasma exchange in polyneuropathy associated with monoclonal gammopathy of undetermined significance. ? Engl J Med 1991; 325: 1482–1486.CrossRefGoogle ScholarPubMed