Skip to main content Accessibility help
×
Home
Hostname: page-component-cf9d5c678-h2mp8 Total loading time: 0.498 Render date: 2021-07-27T21:45:39.055Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

On the Urgent Need for Successful Randomized Controlled Trials in Neurosciences

Published online by Cambridge University Press:  02 December 2014

Samuel Wiebe
Affiliation:
University of Calgary, Calgary, Alberta, Canada
Michael D. Hill
Affiliation:
University of Calgary, Calgary, Alberta, Canada
Rights & Permissions[Opens in a new window]

Abstract

Image of the first page of this article. For PDF version, please use the ‘Save PDF’ preceeding this image.
Type
Editorial
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1 Sackett, DL. Bias in analytic research. J Chronic Dis. 1979;32: 5163.CrossRefGoogle ScholarPubMed
2 MRC Streptomycin in Tuberculosis Trials Committee. Streptomycin treatment for pulmonary tuberculosis. Br Med J. 1948;ii:769–82.Google Scholar
3 Schulz, KF, Chalmers, I, Hayes, RJ, Altman, DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273(5):408–12.CrossRefGoogle ScholarPubMed
4 The EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. N Engl J Med. 1985;313:1191–200.CrossRefGoogle ScholarPubMed
5 Sackett, DL, Hoey, J. Why randomized controlled trials fail but needn’t: a new series is launched. CMAJ. 2000 May 2;162(9): 1301–2.Google Scholar
6 Hebert, PC, Fergusson, DA. Are we keeping research participants safe enough? CMAJ. 2010 July 13;182(10):E428.CrossRefGoogle ScholarPubMed
7 Lehrer, J. The truth wears off. Is there something wrong with the scientific method? The New Yorker. 2010 December 13.Google Scholar
8 Ioannidis, JP. Contradicted and initially stronger effects in highly refd clinical research. JAMA. 2005 July 13;294(2):218–28.CrossRefGoogle ScholarPubMed
You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

On the Urgent Need for Successful Randomized Controlled Trials in Neurosciences
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

On the Urgent Need for Successful Randomized Controlled Trials in Neurosciences
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

On the Urgent Need for Successful Randomized Controlled Trials in Neurosciences
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *