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Meta-Analysis of the ACE Gene Polymorphism in Cerebral Infarction

Published online by Cambridge University Press:  02 December 2014

Hong-miao Tao ,
Bei Shao  and
Guo-zhong Chen
Hong-miao Tao
Affiliation:
School of Medicine, Jinhua College of Profession and Technology, Wenzhou 325000, Zhejiang Province, The People's Republic of China
Bei Shao*
Affiliation:
Cerebrovascular Department, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, The People's Republic of China
Guo-zhong Chen
Affiliation:
School of Medicine, Jinhua College of Profession and Technology, Wenzhou 325000, Zhejiang Province, The People's Republic of China
*
Cerebrovascular Department, the First Affiliated Hospital, Wenzhou Medical College,Wenzhou 325000, Zhejiang Province, The People's Republic of China.
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Abstract

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Background:

The angiotensin-1 converting enzyme (ACE) gene is known to have two polymorphic alleles insertion/deletion(I/D). People with the DD genotype have been shown to be at greater risk of cerebral infarction, but only in some studies. Identification of cerebral infarction susceptibility genes and quantification of associated risks have been hampered by conflicting results from underpowered case-control studies. This meta-analysis was made to look specifically into the genetics of cerebral infarction among Han Chinese population.

Methods:

Genetic associations studies published from January 1, 1990 to December 30, 2007 were collected from databases of MEDLINE, EMBASE, CBM and CNKI. Data were extracted using standardised forms and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

Results:

Twenty-nine original case-control studies of Han Chinese population, comprising 3654 patients with cerebral infarction and 3058 controls were included in the meta-analysis. Using the random effects model, the pooled ORs of ACE DD genotype VS ID+ II was 1.91 (95% CI 1.56 to 2.34, P<0.00001).

Conclusions:

These data suggest that the ACE DD genotype may be a risk factor for cerebral infarction in Han Chinese population. A large scale case-control study is needed to clarify the functional effect of the polymorphism of the ACE I/D gene in the pathogenesis of cerebral infarction in Han Chinese population.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 36 , Issue 1 , January 2009 , pp. 20 - 25
Copyright
Copyright © The Canadian Journal of Neurological 2009

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