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Experimental Study of NADPH-Diaphorase Positive Neurons in Nucleus Accumbens of Rats

Published online by Cambridge University Press:  18 September 2015

Yan Zhao  and
Ke-Wei Huang
Yan Zhao*
Affiliation:
Neuropathology Laboratory, Chinese Pia General Hospital, Beijing
Ke-Wei Huang
Affiliation:
Neuropathology Laboratory, Chinese Pia General Hospital, Beijing
*
Neuropathology Laboratory, Chinese Pia General Hospital, Beijing, 100853 People’s Republic of China
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Abstract

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Background

In order to explain the mechanism for the sparing of the nucleus accumbens in several pathologic conditions, the accumbens, caudate and putamen were examined in an experimental model.

Methods

The neurons in these regions from twenty adult rats were stained for the enzyme nicotinamide adenine dinucleotide phosphate (NADPH-diaphorase) and quantified.

Results

Positive neurons in the nucleus accumbens were more abundant than in the caudate and putamen.

Conclusions

Since these neurons have been shown to be resistant to ischemia and degeneration, it is suggested that the mechanism for the sparing of the nucleus accumbens is related to the presence of a large number of NADPH-diaphorase positive neurons.

Résumé

Résumé<span class='italic'><span class='bold'>Introduction</span></span>

Afin d’expliquer le mécanisme responsable de l’épargne sélective du noyau accumbens (Ace) dans plusieurs états pathologiques, nous avons examiné l’Ace, le noyau caudé et le putamen (Ca-Pu) d’un modèle expérimental.

<span class='italic'><span class='bold'>Méthodes</span></span>

Nous avons coloré et quantifié les neurones de ces régions pour l’enzyme nicotinamide adenine dinucléotide phosphate diaphorase (NADPH-diaphorase) chez 20 rats adultes.

<span class='italic'><span class='bold'>Résultats</span></span>

Les neurones positifs étaient plus nombreux dans l’Ace que dans le Ca-Pu, ce qui n’avait jamais été documenté antérieurement.

<span class='italic'><span class='bold'>Conclusions</span></span>

Comme il est connu que ces neurones sont résistants à l’ischémie et à la dégénérescence, nous suggérons que l’épargne de l’Ace est due à la présence d’un grand nombre de neurones NADPH-diaphorase positifs.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 22 , Issue 4 , November 1995 , pp. 294 - 296
Copyright
Copyright © Canadian Neurological Sciences Federation 1995

References

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