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A Double-Blind Cross-over Trial of Amantadine Hydrochloride in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

A. Filla ,
G. De Michele ,
G. Orefice ,
F. Santarelli ,
L. Trombetta ,
S. Banfi ,
F. Squitieri ,
G. Napolitano ,
D. Puma  and
G. Campanella
A. Filla*
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. De Michele
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. Orefice
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
F. Santarelli
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
L. Trombetta
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
S. Banfi
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
F. Squitieri
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. Napolitano
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
D. Puma
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. Campanella
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
*
Prof. Filla, Clinica Neurologica, Seconda Facoltà di Medicina, via Pansini 5, 80131, Napoli, Italy
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Abstract:

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We performed a double-blind cross-over study with amantadine hydrochloride in 12 patients with Friedreich's disease and 2 with autosomal dominant cerebellar ataxia. Patients were randomly assigned to a placebo-amantadine or amantadine-placebo sequence. The interval between the treatments was two weeks. Patients were graded according to a functional ataxia scoring scale and videotaped in basal conditions and 90 min after a single oral dose of 100 mg amantadine or placebo. Three evaluators independently scored the videotapes. Statistical analysis showed no significant effect of amantadine in Friedreich's disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 1 , February 1993 , pp. 52 - 55
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

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