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Alzheimer's Disease: Metabolic Uncoupling of Associative Brain Regions

Published online by Cambridge University Press:  18 September 2015

Stanley I. Rapoport ,
Barry Horwitz ,
James V. Haxby  and
Cheryl L. Grady
Stanley I. Rapoport*
Affiliation:
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
Barry Horwitz
Affiliation:
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
James V. Haxby
Affiliation:
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
Cheryl L. Grady
Affiliation:
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
*
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD U.S.A. 20892
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Abstract:

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Evidence indicates that Alzheimer's disease (AD) causes functional disconnection of neocortical association areas. In mildly demented AD patients without measurable neocortically-mediated cognitive abnormalities, positron emission tomography demonstrates reduced parietal lobe glucose metabolism and left/right metabolic asymmetries in neocortical association areas. Similar metabolic abnormalities occur in moderately demented patients, but are accompanied by appropriate language and visuospatial discrepancies. Left/right metabolic asymmetries correspond with reduced numbers of partial correlations between metabolic rates in homologous right and left regions, and in the frontal and parietal cortices, indicating metabolic uncoupling among these regions. The affected association regions are those which demonstrate Alzheimer-type neuropathology post-mortem.

Type
Imaging of Demented Subjects
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 540 - 545
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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