Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-26T15:24:20.309Z Has data issue: false hasContentIssue false

Underuse of prehospital strategies to reduce time to reperfusion for ST-elevation myocardial infarction patients in 5 Canadian provinces

Published online by Cambridge University Press:  21 May 2015

Michael J. Schull
Affiliation:
Institute for Clinical Evaluative Sciences, Toronto, Ont. the Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ont. Sunnybrook Health Sciences Centre, Toronto, Ont.
Samuel Vaillancourt
Affiliation:
the Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ont.
Linda Donovan
Affiliation:
Institute for Clinical Evaluative Sciences, Toronto, Ont.
Lucy J. Boothroyd
Affiliation:
Agence d'évaluation des technologies et des modes d'intervention en santé, Montréal, Que.
Dug Andrusiek
Affiliation:
Institute for Clinical Evaluative Sciences, Toronto, Ont. Emergency and Health Services Commission, Vancouver, BC
John Trickett
Affiliation:
Base Hospital Program, Ottawa Hospital, Ottawa, Ont.
Sunil Sookram
Affiliation:
the Department of Emergency Medicine, University of Alberta, Calgary, Alta.
Andrew Travers
Affiliation:
Emergency Health Services, Halifax, NS
Marian J. Vermeulen
Affiliation:
Institute for Clinical Evaluative Sciences, Toronto, Ont.
Jack V. Tu
Affiliation:
Institute for Clinical Evaluative Sciences, Toronto, Ont. Agence d'évaluation des technologies et des modes d'intervention en santé, Montréal, Que. Department of Medicine, University of Toronto, Toronto, Ont.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

Timely reperfusion therapy for ST-elevation myocardial infarction (STEMI) is an important determinant of outcome, yet targets for time to treatment are frequently unmet in North America. Prehospital strategies can reduce time to reperfusion. We sought to determine the extent to which emergency medical services (EMS) use these strategies in Canada.

Methods:

We carried out a cross-sectional survey in 2007 of ground EMS operators in British Columbia, Alberta, Ontario, Quebec and Nova Scotia. We focused on the use of 4 prehospital strategies: 1) 12-lead electrocardiogram (ECG), 2) routine expedited emergency department (ED) transfer of STEMI patients (from a referring ED to a percutaneous coronary intervention [PCI] centre), 3) prehospital bypass (ambulance bypass of local EDs to transport patients directly to PCI centres) and 4) prehospital fibrinolysis.

Results:

Ninety-seven ambulance operators were surveyed, representing 15 681 paramedics serving 97% of the combined provincial populations. Of the operators surveyed, 68% (95% confidence interval [CI] 59%–77%) had ambulances equipped with 12-lead ECGs, ranging from 40% in Quebec to 100% in Alberta and Nova Scotia. Overall, 47% (95% CI 46%-48%) of paramedics were trained in ECG acquisition and 40% (95% CI 39%–41%) were trained in ECG interpretation. Only 18% (95% CI 10%–25%) of operators had prehospital bypass protocols; 45% (95% CI 35%–55%) had protocols for expedited ED transfer. Prehospital fibrinolysis was available only in Alberta. All EMS operators in British Columbia, Alberta and Nova Scotia used at least 1 of the 4 prehospital strategies, and one-third of operators in Ontario and Quebec used 0 of 4. In major urban centres, at least 1 of the 3 prehospital strategies 12-lead ECG acquisition, bypass or expedited transfer was used, but there was considerable variation within and across provinces.

Conclusion:

The implementation of widely recommended prehospital STEMI strategies varies substantially across the 5 provinces studied, and relatively simple existing technologies, such as prehospital ECGs, are underused in many regions. Substantial improvements in prehospital services and better integration with hospital-based care will be necessary in many regions of Canada if optimal times to reperfusion, and associated outcomes, are to be achieved.

Type
Original Research • Recherche originale
Copyright
Copyright © Canadian Association of Emergency Physicians 2009

References

REFERENCES

1.Nallamothu, BK, Bates, ER, Herrin, J, et al Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 analysis. Circulation 2005;111:761–7.Google Scholar
2.Boersma, E, Maas, AC, Deckers, JW, et al Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet 1996;348:771–5.Google Scholar
3.De Luca, G, Ernst, N, Suryapranata, H, et al Relation of interhospital delay and mortality in patients with ST-segment elevation myocardial infarction transferred for primary coronary angioplasty. Am J Cardiol 2005;95:1361–3.Google Scholar
4.McLellan, CS, Le May, MR, Labinaz, M. Current reperfusion strategies for ST elevation myocardial infarction: a Canadian perspective. Can J Cardiol 2004;20:525–33.Google Scholar
5.Steg, PG, Bonnefoy, E, Chaubaud, S, et al Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trial. Circulation 2003;108:2851–6.Google Scholar
6.Nallamothu, BK, Bates, ER. Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything? Am J Cardiol 2003;92:824–6.Google Scholar
7.Antman, EM, Hand, M, Armstrong, PW, et al 2007 Focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2008;117:296329.Google Scholar
8.Nallamothu, BK, Bradley, EH, Krumholz, HM. Time to treatment in primary percutaneous coronary intervention. N Engl J Med 2007;357:1631–8.Google Scholar
9.Eagle, KA, Goodman, SG, Avezum, A, et al Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE). Lancet 2002;359:373–7.Google Scholar
10.Tu, JV. Quality of cardiac care in Ontario. Toronto (ON): Institute for Clinical Evaluative Sciences; 2005.Google Scholar
11.Welsh, RC, Ornato, J, Armstrong, PW. Prehospital management of acute ST-elevation myocardial infarction: a time for reappraisal in North America. Am Heart J 2003;145:18.Google Scholar
12.The Macstrack Project Office. ACO — understanding time to treatment. Macstrak Quarterly 2004;11:12.Google Scholar
13.The Macstrack Project Office. Practice guidelines — acute coronary occlusion (ACO). Macstrak Quarterly 2005;12:12.Google Scholar
14.The Macstrack Project Office. Reperfusion therapy time reports updated. Macstrak Quarterly 2007;14:12.Google Scholar
15.Brainard, AH, Raynovich, W, Tandberg, D, et al The prehospital 12-lead electrocardiogram’s effect on time of initiation of reperfusion therapy: a systematic review and meta-analysis of existing literature. Am J Emerg Med 2005;23:351–6.Google Scholar
16.Garvey, JL, MacLeod, BA, Sopko, G, et al Pre-hospital 12-lead electrocardiography programs: a call for implementation by emergency medical services systems providing advanced life support — National Heart Attack Alert Program (NHAAP) Coordinating Committee; National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health. J Am Coll Cardiol 2006;47:485–91.Google Scholar
17.Morrison, LJ, Brooks, S, Sawadsky, B, et al Prehospital 12-lead electrocardiography impact on acute myocardial infarction treatment times and mortality: a systematic review. Acad Emerg Med 2006;13:84–9.Google Scholar
18.Adams, GL, Campbell, PT, Adams, JL. Effectiveness of prehospital wireless transmission of electrocardiograms to a cardiologist via hand-held device for patients with acute myocardial infarction. Am J Cardiol 2006;98:1160–4.Google Scholar
19.American Heart Association. D2B: an alliance for quality. Available: http://www.d2balliance.org (accessed 2009 Jul 28).Google Scholar
20.de Villiers, JS, Anderson, T, McMeekin, JD, et al Expedited transfer for primary percutaneous coronary intervention: a program evaluation. CMAJ 2007;176:1833–8.Google Scholar
21.Jollis, JG, Roettig, ML, Aluko, AO, et al Implementation of a statewide system for coronary reperfusion for ST-segment elevation myocardial infarction. JAMA 2007;298:2371–80.Google Scholar
22.Le May, MR, Davies, RF, Dionne, R, et al Comparison of early mortality of paramedic-diagnosed ST-segment eleveation myocardial infarction with immediate transport to a designated primary percutaneous coronary intervention center to that of similar patients transported to the nearest hospital. Am J Cardiol 2006;98:1329–33.Google Scholar
23.Ortolani, P, Marzocchi, A, Marrozzini, C, et al Clinical impact of direct referral to primary percutaneous coronary intervention following pre-hospital diagnosis of ST-elevation myocardial infarction. Eur Heart J 2006;27:1550–7.Google Scholar
24.Dorsch, MF, Greenwood, JP, Priestley, C. Direct ambulance admission to the cardiac catheterization laboratory significantly reduces door-to-balloon times in primary percutaneous coronary intervention. Am Heart J 2008;155:1054–8.Google Scholar
25.Armstrong, PW. A comparison of pharmacological therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study. Eur Heart J 2006;27:1530–8.Google Scholar
26.Bjorklund, E, Stenestrand, U, Lindback, J, et al Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction. Eur Heart J 2006;27:1146–52.Google Scholar
27.Bonnefoy, E, Lapostolle, F, Leizorovicz, A, et al Primary angioplasty versus prehospital fibrinolysis in acute myocar-dial infarction: a randomised study. Lancet 2002;360:825–9.Google Scholar
28.Danchin, N, Blanchard, D, Steg, PG, et al Impact of prehospital thrombolysis for acute myocardial infarction on 1-year outcome: results from the French Nationwide USIC 2000 Registry. Circulation 2004;110:1909–15.Google Scholar
29.Lamfers, EJ, Schut, A, Hertzberger, DP, et al Prehospital versus hospital fibrinolytic therapy using automated versus cardiologist electrocardiographic diagnosis of myocardial infarction: abortion of myocardial infarction and unjustified fibrinolytic therapy. Am Heart J 2004;147:509–15.Google Scholar
30.Morrison, LJ, Verbeek, PR, McDonald, AC, et al Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis. JAMA 2000;283:2686–92.Google Scholar
31.Morrow, DA, Antman, EM, Sayah, A, et al Evaluation of the time saved by prehosptial initiation of reteplase for ST-elevation myocardial infarction: results of The Early Retavase-Thrombolysis in Myocardial Infarction (ER-TIMI) 19 trial. J Am Coll Cardiol 2002;40:71–7.Google Scholar
32.Welsh, RC, Travers, A, Senaratne, M, et al Feasibility and applicability of paramedic-based prehospital fibrinolysis in a large North American center. Am Heart J 2006;152:1007–14.Google Scholar
33.Armstrong, PW, Bogaty, P, Buller, CE, et al The 2004 ACC/AHA Guidelines: a perspective and adaptation for Canada by the Canadian Cardiovascular Society Working Group. Can J Cardiol 2004;20:1075–9.Google Scholar
34.Moyer, P, Ornato, JP, Brady, WJ Jr, et al Development of systems of care for ST-elevation myocardial infarction patients: the emergency medical services and emergency department perspective. Circulation 2007;116:e43–8.Google Scholar
35.Canto, JG, Rogers, WJ, Bowlby, LJ, et al The prehospital electrocardiogram in acute myocardial infarction: is its full potential being realized? National Registry of Myocardial Infarction 2 Investigators. J Am Coll Cardiol 1997;29:498505.Google Scholar
36.Census 2006. Ottawa (ON): Statistics Canada; 2006. Available: http://www12.statcan.gc.ca/census-recensement/2006/geo/index-eng.cfm (accessed 2009 Jul 24).Google Scholar
37.Williams, DM. 200 city survey: Is the status quo acceptable? JEMS 2008;33:4865.Google Scholar
38.Antman, EM, Anbe, DT, Armstrong, PW, et al ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction; A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of patients with acute myocardial infarction). J Am Coll Cardiol 2004;44:E1–211.Google Scholar
39.Adams, GL, Campbell, PT, Adams, JM, et al Effectiveness of prehospital wireless transmission of electrocardiograms to a cardiologist via hand-held device for patients with acute myocardial infarction (from the Timely Intervention in Myocardial Emergency, NorthEast Experience [TIME-NE]). Am J Cardiol 2006;98:1160–4.Google Scholar
40.Bradley, EH, Herrin, J, Wang, Y, et al Strategies for reducing the door-to-balloon time in acute myocardial infarction. N Engl J Med 2006;355:2308–20.Google Scholar
41.Clemmensen, P, Sejersten, M, Sillesen, M, et al Diversion of ST-elevation myocardial infarction patients for primary angioplasty based on wireless prehospital 12-lead electrocardiographic transmission directly to the cardiologist’s handheld computer. J Electrocardiol 2005;38:194–8.Google Scholar
42.Drew, BJ, Dempsey, ED, Joo, TH, et al Pre-hospital synthesized 12-lead ECG ischemia monitoring with trans-telephonic transmission in acute coronary syndromes: pilot study results of the ST SMART trial. J Electrocardiol 2004;37:214–21.Google Scholar
43.Gross, BW, Dauterman, KW, Moran, MG, et al An approach to shorten time to infarct patency in patients with ST-segment elevation myocardial infarction. Am J Cardiol 2007;99:1360–3.Google Scholar
44.Le May, MR, So, DY, Dionne, R, et al A citywide protocol for primary PCI in ST-segment elevation myocardial infarction. N Engl J Med 2008;358:231–40.Google Scholar
45.Sekulic, M, Hassunizadeh, B, McGraw, S, et al Feasibility of early emergency room notification to improve door-to-balloon times for patients with acute ST segment elevation myocardial infarction. Catheter Cardiovasc Interv 2005;66:316–9.Google Scholar
46.Strauss, DG, Sprague, PQ, Underhill, K, et al Paramedic transtelephonic communication to cardiologist of clinical and electrocardiographic assessment for rapid reperfusion of ST-elevation myocardial infarction. J Electrocardiol 2007;40:265–70.Google Scholar
47.Swor, R, Hegerberg, S, McHugh-McNally, A, et al Prehospital 12-lead ECG: Efficacy or effectiveness? Prehosp Emerg Care 2006;10:374–7.Google Scholar
48.Terkelsen, CJ, Lassen, JF, Norgaard, BL, et al Reduction in treatment delay in patients with ST-elevation myocardial infarction: Impact of pre-hospital diagnosis and direct referral to primary percutaneous coronary intervention. Eur Heart J 2005;26:770–7.Google Scholar
49.van’t Hof, AW, Rasoul, S, van de Wetering, H, et al Feasibility and benefit of prehospital diagnosis, triage, and therapy by paramedics only in patients who are candidates for primary angioplasty for acute myocardial infarction. Am Heart J 2006;151:1255 e1–5.Google Scholar
50.Alter, DA, Stukel, TA, Newman, A. The relationship between physician supply, cardiovascular health service use and cardiac disease burden in Ontario: supply-need mismatch. Can J Cardiol 2008;24:187–93.Google Scholar