Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-23T16:23:55.239Z Has data issue: false hasContentIssue false
  • English
  • Français

The Role of EMS in Regionalized Systems of Care

Published online by Cambridge University Press:  15 June 2015

Ian R. Drennan  and
P. Richard Verbeek
Ian R. Drennan*
Affiliation:
Rescu, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON York Region Emergency Medical Services, York Region, ON Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON.
P. Richard Verbeek
Affiliation:
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON.
*
Correspondence to: Ian R. Drennan, Rescu, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 30 Bond St., Toronto, ON, M5B 1W8; Email: drennanI@smh.ca

Abstract

The parallel advancement of prehospital and in-hospital patient care has provided impetus for the development and implementation of regionalized systems of health care for patients suffering from acute, life-threatening injury and illness. Regardless of the patient’s clinical condition, regionalized systems of care revolve around the premise of providing the right care to the right patient at the right time. Current regionalization strategies have shown improvements in the time to patient treatment and in patient outcome, with the incorporation of emergency medical services (EMS) bypass as a key component of the system of care. This article discusses the emerging role of EMS as a critical component of regionalized systems essential to ensure effective and efficient use of resources to improve patient outcome. We also examine some of the benefits and barriers to implementation of regionalized systems of care and avenues for future research.

Résumé

L’évolution en parallèle des soins préhospitaliers et hospitaliers a donné une impulsion à l’élaboration et à la mise en place de systèmes régionalisés de soins de santé pour les patients souffrant de blessures ou de maladies aiguës potentiellement mortelles. Peu importe l’état clinique du patient, les systèmes régionalisés de soins de santé ont pour prémisse la prestation de soins appropriés au bon patient, au bon moment. Les stratégies actuelles de régionalisation ont déjà permis d’améliorer les délais de traitement et les résultats cliniques, grâce à l’incorporation du programme auxiliaire des services médicaux d’urgence (SMU) en tant que l’un des principaux constituants du système de soins. Il sera question dans l’article du nouveau rôle des SMU en tant qu’élément crucial des systèmes régionaux et maillon essentiel à l’utilisation efficace et efficiente des ressources en vue de l’amélioration des résultats cliniques. Les auteurs examineront également certains avantages de la mise en place des systèmes régionalisés de soins de santé, ainsi que certains obstacles, et proposeront de nouvelles voies de recherche à explorer dans l’avenir.

Keywords

EMSParamedicSystems of Care
Type
Editorial/Commentary
Information
Canadian Journal of Emergency Medicine , Volume 17 , Issue 4 , July 2015 , pp. 468 - 474
Copyright
Copyright © Canadian Association of Emergency Physicians 2015 

EDITORIAL

Patients suffering from life-threatening illness and trauma require specialized, time-sensitive interventions to ensure the best possible outcome and return to a high quality of life. This concept is well established throughout medicine, perhaps most notably with regards to trauma, the “golden hour.” Although there is nothing magical about the one-hour mark in trauma, it does represent an important concept; rapid, specialized treatment results in improved clinical outcomes.Reference Kajino, Iwami and Daya 1 This time-sensitive concept is applied to a number of high-intensity, critical conditions, including ST-elevation myocardial infarction (STEMI)Reference O'Connor, Brady and Brooks 2 , cerebrovascular accident (CVA)Reference Wardlaw, Murray and Berge 3 , out-of-hospital cardiac arrest (OHCA)Reference Callaway, Schmicker and Kampmeyer 4 , and sepsis.Reference Dellinger, Levy and Rhodes 5 , Reference Kumar, Roberts and Wood 6

Since the era of bed rest for the treatment of STEMI in the 1960sReference Braunwald 7 , the treatment of this and many other life-threatening conditions has undergone profound changes, leading to the development of “regionalized systems of care” using hospital-based “centres of excellence,” which provide advanced diagnostics, interventions, and expertise not routinely available in typical referral hospitals. Only recently has the importance of emergency medical services (EMS) been recognized as a key component.

Historically, despite regionalized systems of care, patients were transported by EMS to the closest emergency department (ED) regardless of their clinical condition. It was thought, due to the potential risk of deterioration during longer transports, and a lack of evidence that paramedics could safely identify and treat these patients, that initial stabilization at the local ED was necessary prior to transfer to a higher level of medical care. This often resulted in significant delays to definitive care.Reference Doumouras, Haas and Gomez 8 - Reference Carstensen, Nelson and Hansen 10 It may have inadvertently also resulted in some patients never being transferred to a known centre of excellence.

EMS providers combine increased skill in patient assessment and diagnostics with life-saving interventions to provide high-quality prehospital emergency care. Paramedics are now able to appropriately manage a wide variety of critically ill patients whom they previously would not have had the equipment, training, or expertise to handle. 11 Furthermore, recent research examining the effect of EMS transport interval on patient outcome suggests that longer transport times (up to 35 minutes) are not associated with adverse patient outcomes for both severe trauma and OHCA.Reference Newgard, Schmicker and Hedges 12 - Reference Spaite, Stiell and Bobrow 14 This new appreciation for advancements in EMS care has provided the impetus to expand the reach of centres of excellence into the prehospital setting. The parallel advancement of in-hospital and prehospital patient care has provided the opportunity to integrate prehospital bypass programs into regionalized systems of care, resulting in a systems-based approach that we see in many areas of health care today.

Components of regionalized systems of care

There is a mounting body of evidence that shows improvements in patient morbidity and mortality with regionalized systems of care.Reference Cameron, Gabbe and Cooper 15 - Reference MacKenzie, Rivara and Jurkovich 17 The importance of developing regionalized systems is further supported by a number of national organizations in Canada and the United States.Reference Acker, Pancioli and Crocco 18 - Reference Welsh, Travers and Huynh 21 Historically, the drivers of regionalized systems of care have been trauma and STEMI; however, other systems include stroke, traumatic brain injury (TBI)Reference Spaite, Bobrow and Stolz 22 , OHCAReference Callaway, Schmicker and Kampmeyer 4 , Reference Nichol, Aufderheide and Eigel 23 , and burnsReference Ahmed, Van Heukelom and Harland 24 (Table 1). Regardless of the specific illness or injury, regional strategies designed around systems of care require the integration of a number of common key components in order to be successfully implemented, provide optimal patient care, and maximize health care efficiency. There are a number of priority stakeholders impacted by regionalized systems of care that must all be involved in the planning and implementation to ensure success. A priori agreements must be arranged between EMS services, referral hospitals, and receiving facilities, to allow for seamless transitions in patient care, and to ensure that the patient is cared for at the most appropriate destination.

Table 1 Typical and potential regionalized systems of care.

Some of the common elements of an effective regionalized system of care include:

  1. (i) The Public, who must recognize a life-threatening condition and appropriately activate the 911 response, as opposed to going on their own to an ED of their choice.

  2. (ii) EMS Agencies and EMS Medical Direction, including expertly trained paramedics, EMS personnel, and medical dispatchers, as well as medical oversight by medical committees and EMS physicians.

  3. (iii) EMS Bypass Criteria/Protocols, specific for each illness/injury, to aid in patient identification, bypass of closest EDs, and advance notification of centres of excellence by EMS.

  4. (iv) Interfacility Transfer Protocols, between EMS and referral hospitals, to ensure rapid transfer by appropriately trained personnel to the centre of excellence.

  5. (v) Regional Centres of Excellence, equipped with facilities, staff, and resources to provide optimal and definitive care 24/7 for critically injured or ill patients.

  6. (vi) Rehabilitation Systems, which must be in place to ensure appropriate care during the recovery process.

  7. (vii) Quality Assurance Programs, to monitor and continually assess/improve/ report system of care performance.

Emergency medical services impact on patient care

There are a number of personnel and health care practitioners involved in the different components required for an effective EMS system of care. This commentary focuses on the impact of advancements made with frontline paramedics that have allowed bypass programs to develop and integrate into our health care system. EMS providers can have a significant impact on patient outcomes. Perhaps the most important responsibility of EMS providers is determining the “right place” for patient care. Rapid and accurate triage by paramedics to appropriate destinations can have a significant impact on patient outcome, more so than intravenous therapy, endotracheal intubation, and most other interventions applied in the field.Reference Liberman, Mulder and Sampalis 27 Prehospital bypass has been shown to significantly reduce the time to arrival at a trauma centre, which in turn is directly related to improved patient outcome.Reference Haas, Stukel and Gomez 28 , Reference Haas, Gomez and Zagorski 29 A recent study by Gomez et al concluded that prehospital bypass was associated with a 3.5 hour (IQR 1.7 to 4.5 hours) reduction in time to arrival at a trauma centre, compared to transport and subsequent transfer from a non-trauma centre;Reference Gomez, Haas and de Mestral 30 this reduction in time is important, considering that the majority of deaths from trauma occur within the first 24 hours after injury.Reference Acosta, Yang and Winchell 31 Similarly, prehospital stroke bypass has improved patient access to thrombolytics,Reference Gladstone, Rodan and Sahlas 32 and STEMI bypass programs have significantly reduced the time from initial medical contact to percutaneous coronary intervention (PCI), compared to initial transportation to the nearest EDReference Cheskes, Turner and Foggett 9 , Reference Le May, Davies and Dionne 33 . These cardiac programs have been shown to be associated with a decrease in short-term mortality.Reference Nam, Caners and Bowen 34

Identification of patients who would benefit from prehospital bypass protocols should be a major focus for EMS systems, and should be based upon a number of important endpoints, such as death, disease (morbidity), disability, discomfort, dissatisfaction, and destitution (cost).Reference Cone, Brooke Lerner and Band 35 In order to be effective, paramedics and other EMS providers must be provided with and trained in validated, evidence-based tools to assess the need for centre of excellence care, whether based on signs and symptoms of a stroke,Reference Chenkin, Gladstone and Verbeek 36 - Reference Kothari, Pancioli and Liu 38 a 12-lead electrocardiogram (ECG) for identification of STEMI,Reference Le May, Davies and Dionne 33 or criteria to indicate severe trauma 39 . With training and quality improvement programs in place, and using these validated tools, it has been shown that EMS recognition of life-threatening conditions can be extremely accurate, mimicking ED physicians.Reference O'Connor, Brady and Brooks 2 , Reference Camp-Rogers, Dante and Kontos 40 - Reference Feldman, Brinsfield and Bernard 42

Ideal bypass protocols should use validated, objective criteria to help minimize both over- and under-triage. Ineffective bypass systems can lead to increased costs, inefficient use of both hospital-based and EMS resources, and over-crowding of regional-based centres.Reference Gladstone, Rodan and Sahlas 32 Prehospital bypass activates a significant number of resources dedicated to the care of individual patients, decreasing the resources available to care for other patients. Each disease-specific system is unique, and it is therefore difficult to quantify a universal number of false-positives that would be deemed “acceptable.” It is important for each system to decide what is acceptable for their specific situation. For example, there are substantial in-hospital costs associated with PCI.Reference Le May, Davies and Labinaz 43 Activation during “off hours” can result in a number of members of the PCI team being called in from home, placing considerable stress on these individuals. In general, criteria for EMS bypass protocols should aim for high specificity (i.e., not bypassing patients that do not require specialized care). However, as EMS systems aim to limit false-positive activations and achieve a high specificity, there will inevitably be a larger number of patients requiring specialized care that will not undergo bypass and will instead be transported to the closest ED. Validated, easy to apply protocols would allow for accurate, rapid, and safe application by paramedics in high-intensity, chaotic emergency situations.

The development of prehospital bypass programs can have a significant impact on EMS service delivery. EMS systems must invest substantial time dedicated to training and continued quality assurance of program performance. This can be a significant barrier to implementation. Furthermore, regional strategies require ambulances to transport patients to centres of excellence, often bypassing the closest hospital and transporting to hospitals outside their region of coverage. This could result in extended periods of time where ambulances are not available for other 911 responses, and ultimately may result in a larger number of ambulances required to maintain consistent levels of local emergency coverage. There is currently a lack of research examining the impact that bypass programs and ambulance diversion have on ambulance resource utilization, and this is an area that requires further investigation.

Emergency department and in-hospital impact

Implementation of regional patient care strategies can have a major impact on ED and in-hospital care. Redistribution of patients across hospitals means that centres of excellence must maintain sufficient bed capacity to care for patients that are transported from within their catchment area. The centre must be capable of offering specialized care at all times, above and beyond the care patients would receive in community hospitals. There is strong evidence that the number of cases treated at a particular institution, or by a particular practitioner, is directly correlated with patient outcome, providing further evidence in support of centres of excellence.Reference Callaway, Schmicker and Kampmeyer 4 , Reference Granger, Henry and Bates 44 - Reference Nathens, Jurkovich and Maier 47

There are a number of reasons why patients requiring specialized care may not be bypassed to a centre of excellence, including: a) a substantial proportion of patients do not live within the catchment area and are not eligible for prehospital bypass programs;Reference Hameed, Schuurman and Razek 48 , Reference Patel, Tu and Waters 49 b) a significant number of patients do not call 911 and instead seek medical attention on their own; and c) a paramedic may not identify a patient who qualifies for prehospital bypass, or the condition of interest may not develop until after the patient has arrived at the general ED.

Since many patients are initially assessed and treated at non-specialized centres, referral hospitals are essential in optimizing efficiency in a regionalized system. Interfacility transfer agreements must be developed to ensure that there is comprehensive region-wide access to a centre of excellence. EMS agencies must be able to quickly respond to requests from referral hospitals for patient transfers, sending appropriately trained paramedics to manage the patient’s condition. To ensure efficient use of health care resources, interfacility agreements must consider repatriation of patients back to their community hospital, either because they were ineligible to receive specialized treatment, or once stable post-procedure, to continue in their recovery process. Repatriation will help to ensure that health care resource consumption is redistributed back to referral hospitals and that centres of excellence do not become over-burdened.

Barriers to implementation

Despite the success of regionalized systems of care, there are a number of barriers to implementation of these systems across Canada.

All systems of care require lay bystanders to rapidly recognize a potential life-threatening emergency and to activate the 911 system. Delays in activation of 911 often account for the largest delay from symptom onset to definitive care.Reference Millin, Brooks and Travers 50 Average delays to hospital arrival for STEMI patients have been shown to be between 1.5 and six hours from symptom onset.Reference Moser, Kimble and Alberts 51 Furthermore, once a patient decides to seek medical care, a substantial number of patients with concerning symptoms do not utilize 911. Improvements in public awareness and educational campaigns regarding signs and symptoms and the benefits of 911-based care may help to improve this vital link.

Geographic barriers can limit the effectiveness of regionalized systems of care. As Canada is a large and mostly rural country, a significant proportion of the population lives outside of the catchment area of centres of excellence, and is unable to be transported by EMS within a reasonable timeframe. In Canada, it is estimated that 23% of the population (> seven million people) live beyond a one-hour drive from a level I or level II trauma centre,Reference Hameed, Schuurman and Razek 48 and since current bypass protocols in some provinces limit ambulance bypass travel time to just 30 minutes, this percentage becomes even greater. Similarly, only 85% of patients having an ischemic stroke live within 100 km of a centre capable of treating with thrombolytics.Reference Scott, Temovsky and Lawrence 16

There are also many unknowns regarding the indirect consequences of establishing regionalized systems of care and EMS bypass protocols. For instance, it is not known how implementation of EMS bypass protocols affects the length of time EMS are tied up on a call, the availability of ambulances for future 911 calls, and the impact that extended transport times have on the overall delivery of 911 services. It is critical that further research is done to evaluate the impact that regionalized care may have on the entire 911 system, beyond individual patient outcomes.

Finally, although bypass programs may be implemented into EMS practice, not all patients will be bypassed to a specialized care facility. A recent study of one Canadian EMS agency showed that, despite meeting all inclusion criteria for bypass to a trauma centre, and a median time of transport to the regional trauma centre of 10 minutes, only 53% of eligible patients were transported directly to the trauma centre.Reference Doumouras, Haas and Gomez 8 Furthermore, it was noted that the relationship was dependent upon the differential distance between closest ED and trauma centre.Reference Doumouras, Haas and Gomez 8

Research, or lack thereof, continues to be a major barrier to successful systems of care. Life-threatening conditions are relatively infrequent, and due to the emergent nature, the unpredictable prehospital environment, and the resources required to follow patients over a continuum of care, there are many ethical and logistic challenges to conducting high-quality clinical research in the prehospital setting. As a result, the science behind the who, what, where, when, and why of regionalized systems of care may rely on expert consensus opinion and lower-quality evidence. This means that science may not always be able to drive systems of care.

Future of regionalized emergency care

One can imagine a number of other low-frequency, resource-intensive clinical conditions readily identifiable by paramedics where patients might benefit from direct transport to a centre of excellence. As a result of the success of current regionalized systems, other models of care are being investigated as potential regionalization strategies for OHCA,Reference Kajino, Iwami and Daya 1 , Reference Callaway, Schmicker and Kampmeyer 4 , Reference Carr, Kahn and Merchant 45 sepsis,Reference Kahn, Branas and Schwab 52 and isolated TBI. These strategies, yet to be inducted into widespread clinical practice, have shown promise in improving care and patient outcome. Burns, toxicologic emergencies, amputations, and procurement of donor tissue and organs are other potential indications for care at specialized centres that deserve future consideration.

CONCLUSION

As our health care system continues to evolve we will continue to explore avenues to better treat patients while ensuring efficient and effective use of health care resources. Regionalization of health care has shown promise in a number of time-sensitive critical conditions by improving patient outcomes and optimizing resource utilization. As we continue to make progress in this area of research, it is important to continually monitor and reassess these systems of care, while incorporating input from all stakeholders involved. Strategies incorporating EMS into regionalized systems of care have the potential to make a significant impact on the outcomes of the most critically ill patients.

Competing Interests: None declared.

References

1. Kajino, K, Iwami, T, Daya, M, et al. Impact of transport to critical care medical centers on outcomes after out-of-hospital cardiac arrest. Resuscitation 2010;81(5):549-554.CrossRefGoogle ScholarPubMed
2. O'Connor, RE, Brady, W, Brooks, SC, et al. Part 10: acute coronary syndromes: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010;122(18 Suppl 3):S787-S817.Google Scholar
3. Wardlaw, JM, Murray, V, Berge, E, et al. Thrombolysis for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2009:CD000213.CrossRefGoogle Scholar
4. Callaway, CW, Schmicker, R, Kampmeyer, M, et al. Receiving hospital characteristics associated with survival after out-of-hospital cardiac arrest. Resuscitation 2010;81(5):524-529.Google Scholar
5. Dellinger, RP, Levy, MM, Rhodes, A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41(2):580-637.CrossRefGoogle ScholarPubMed
6. Kumar, A, Roberts, D, Wood, KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34(6):1589-1596.CrossRefGoogle ScholarPubMed
7. Braunwald, E. The treatment of acute myocardial infarction: the Past, the Present, and the Future. Eur Heart J Acute Cardiovasc Care 2012;1(1):9-12.CrossRefGoogle ScholarPubMed
8. Doumouras, AG, Haas, B, Gomez, D, et al. The impact of distance on triage to trauma center care in an urban trauma system. Prehosp Emerg Care 2012;16(4):456-462.Google Scholar
9. Cheskes, S, Turner, L, Foggett, R, et al. Paramedic contact to balloon in less than 90 minutes: a successful strategy for st-segment elevation myocardial infarction bypass to primary percutaneous coronary intervention in a canadian emergency medical system. Prehosp Emerg Care 2011;15(4):490-498.CrossRefGoogle Scholar
10. Carstensen, S, Nelson, GC, Hansen, PS, et al. Field triage to primary angioplasty combined with emergency department bypass reduces treatment delays and is associated with improved outcome. Eur Heart J 2007;28(19):2313-2319.Google Scholar
11. Paramedic Association of Canada National Occupational Competency Profile For Paramedics; 2011. Available at: http://paramedic.ca/site/nocp?nav=02.Google Scholar
12. Newgard, CD, Schmicker, RH, Hedges, JR, et al. Emergency medical services intervals and survival in trauma: assessment of the “golden hour” in a North American prospective cohort. Ann Emerg Med 2010;55(3):235-246.e4.Google Scholar
13. Spaite, DW, Bobrow, BJ, Vadeboncoeur, TF, et al. The impact of prehospital transport interval on survival in out-of-hospital cardiac arrest: implications for regionalization of post-resuscitation care. Resuscitation 2008;79(1):61-66.Google Scholar
14. Spaite, DW, Stiell, IG, Bobrow, BJ, et al. Effect of transport interval on out-of-hospital cardiac arrest survival in the OPALS study: implications for triaging patients to specialized cardiac arrest centers. Ann Emerg Med 2009;54(2):248-255.CrossRefGoogle ScholarPubMed
15. Cameron, PA, Gabbe, BJ, Cooper, DJ, et al. A statewide system of trauma care in Victoria: effect on patient survival. Med J Aust 2008;189(10):546-550.Google Scholar
16. Scott, PA, Temovsky, CJ, Lawrence, K, et al. Analysis of Canadian population with potential geographic access to intravenous thrombolysis for acute ischemic stroke. Stroke 1998;29(11):2304-2310.Google Scholar
17. MacKenzie, EJ, Rivara, FP, Jurkovich, GJ, et al. A national evaluation of the effect of trauma-center care on mortality. N Engl J Med 2006;354(4):366-378.Google Scholar
18. Acker, JE 3rd, Pancioli, AM, Crocco, TJ, et al. Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association Expert Panel on Emergency Medical Services Systems and the Stroke Council. Stroke 2007;38(11):3097-3115.Google Scholar
19. Sasser, SM, Hunt, RC, Faul, M, et al. Guidelines for field triage of injured patients: recommendations of the National Expert Panel on Field Triage, 2011. MMWR Recomm Rep 2012;61(RR01):1-20.Google Scholar
20. Lindsay, P, Bayley, M, McDonald, A, et al. Toward a more effective approach to stroke: Canadian Best Practice Recommendations for Stroke Care. CMAJ 2008;178(11):1418-1425.CrossRefGoogle Scholar
21. Welsh, RC, Travers, A, Huynh, T, et al. Canadian Cardiovascular Society Working Group: Providing a perspective on the 2007 focused update of the American College of Cardiology and American Heart Association 2004 guidelines for the management of ST elevation myocardial infarction. Can J Cardiol 2009;25(1):25-32.Google Scholar
22. Spaite, DW, Bobrow, BJ, Stolz, U, et al. Evaluation of the impact of implementing the emergency medical services traumatic brain injury guidelines in Arizona: the Excellence in Prehospital Injury Care (EPIC) study methodology. Acad Emerg Med 2014;21(7):818-830.Google Scholar
23. Nichol, G, Aufderheide, TP, Eigel, B, et al. Regional systems of care for out-of-hospital cardiac arrest: A policy statement from the American Heart Association. Circulation 2010;121(5):709-729.Google Scholar
24. Ahmed, A, Van Heukelom, P, Harland, K, et al. Characterizing demographics, injury severity, and intubation status for patients transported by air or ground ambulance to a rural burn center. J Burn Care Res 2014;35(3):e151-e158.Google Scholar
25. Gamez, P, Cordoba, M, Ussetti, P, et al. Lung transplantation from out-of-hospital non-heart-beating lung donors. one-year experience and results. J Heart Lung Transplant 2005;24(8):1098-1102.CrossRefGoogle Scholar
26. Fieux, F, Losser, MR, Bourgeois, E, et al. Kidney retrieval after sudden out of hospital refractory cardiac arrest: a cohort of uncontrolled non heart beating donors. Crit Care 2009;13(4):R141.Google Scholar
27. Liberman, M, Mulder, D, Sampalis, J. Advanced or basic life support for trauma: meta-analysis and critical review of the literature. J Trauma 2000;49(4):584-599.CrossRefGoogle ScholarPubMed
28. Haas, B, Stukel, TA, Gomez, D, et al. The mortality benefit of direct trauma center transport in a regional trauma system: a population-based analysis. J Trauma Acute Care Surg 2012;72(6):1510-1515, discussion 1515-7.CrossRefGoogle Scholar
29. Haas, B, Gomez, D, Zagorski, B, et al. Survival of the fittest: the hidden cost of undertriage of major trauma. J Am Coll Surg 2010;211(6):804-811.Google Scholar
30. Gomez, D, Haas, B, de Mestral, C, et al. Institutional and provider factors impeding access to trauma center care: an analysis of transfer practices in a regional trauma system. J Trauma Acute Care Surg 2012;73(5):1288-1293.Google Scholar
31. Acosta, JA, Yang, JC, Winchell, RJ, et al. Lethal injuries and time to death in a level I trauma center. J Am Coll Surg 1998;186(5):528-533.Google Scholar
32. Gladstone, DJ, Rodan, LH, Sahlas, DJ, et al. A citywide prehospital protocol increases access to stroke thrombolysis in Toronto. Stroke 2009;40(12):3841-3844.CrossRefGoogle ScholarPubMed
33. Le May, MR, Davies, RF, Dionne, R, et al. Comparison of early mortality of paramedic-diagnosed ST-segment elevation myocardial infarction with immediate transport to a designated primary percutaneous coronary intervention center to that of similar patients transported to the nearest hospital. Am J Cardiol 2006;98(10):1329-1333.Google Scholar
34. Nam, J, Caners, K, Bowen, JM, et al. Systematic review and meta-analysis of the benefits of out-of-hospital 12-lead ECG and advance notification in ST-segment elevation myocardial infarction patients. Ann Emerg Med 2014;64(2):176-186.CrossRefGoogle ScholarPubMed
35. Cone, DC, Brooke Lerner, E, Band, RA, et al. Prehospital care and new models of regionalization. Acad Emerg Med 2010;17(12):1337-1345.Google Scholar
36. Chenkin, J, Gladstone, DJ, Verbeek, PR, et al. Predictive value of the Ontario prehospital stroke screening tool for the identification of patients with acute stroke. Prehosp Emerg Care 2009;13(2):153-159.Google Scholar
37. Kidwell, CS, Starkman, S, Eckstein, M, et al. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke 2000;31(1):71-76.CrossRefGoogle ScholarPubMed
38. Kothari, RU, Pancioli, A, Liu, T, et al. Cincinnati Prehospital Stroke Scale: reproducibility and validity. Ann Emerg Med 1999;33(4):373-378.Google Scholar
39. Centers for Disease Control and Prevention. Guidelines for Field Triage of Injured Patients: Recommendations of the National Expert Panel on Field Triage. MMWR Surveill Summ 2012;61(1):1-23.Google Scholar
40. Camp-Rogers, T, Dante, S, Kontos, MC, et al. The impact of prehospital activation of the cardiac catheterization team on time to treatment for patients presenting with ST-segment-elevation myocardial infarction. Am J Emerg Med 2011;29(9):1117-1124.CrossRefGoogle Scholar
41. Cantor, WJ, Hoogeveen, P, Robert, A, et al. Prehospital diagnosis and triage of ST-elevation myocardial infarction by paramedics without advanced care training. Am Heart J 2012;164(2):201-206.Google Scholar
42. Feldman, JA, Brinsfield, K, Bernard, S, et al. Real-time paramedic compared with blinded physician identification of ST-segment elevation myocardial infarction: results of an observational study. Am J Emerg Med 2005;23(4):443-448.Google Scholar
43. Le May, MR, Davies, RF, Labinaz, M, et al. Hospitalization costs of primary stenting versus thrombolysis in acute myocardial infarction: cost analysis of the Canadian STAT Study. Circulation 2003;108(21):2624-2630.CrossRefGoogle ScholarPubMed
44. Granger, CB, Henry, TD, Bates, WE, et al. Development of systems of care for ST-elevation myocardial infarction patients: the primary percutaneous coronary intervention (ST-elevation myocardial infarction-receiving) hospital perspective. Circulation 2007;116(2):e55-e59.Google Scholar
45. Carr, BG, Kahn, JM, Merchant, RM, et al. Inter-hospital variability in post-cardiac arrest mortality. Resuscitation 2009;80(1):30-34.Google Scholar
46. Carr, BG, Goyal, M, Band, RA, et al. A national analysis of the relationship between hospital factors and post-cardiac arrest mortality. Intensive Care Med 2009;35(3):505-511.Google Scholar
47. Nathens, AB, Jurkovich, GJ, Maier, RV, et al. Relationship between trauma center volume and outcomes. JAMA 2001;285(9):1164-1171.Google Scholar
48. Hameed, SM, Schuurman, N, Razek, T, et al. Access to trauma systems in Canada. J Trauma 2010;69(6):1350-1361, discussion 1361.Google Scholar
49. Patel, AB, Tu, JV, Waters, NM, et al. Access to primary percutaneous coronary intervention for ST-segment elevation myocardial infarction in Canada: a geographic analysis. Open Med 2010;4(1):e13-e21.Google Scholar
50. Millin, MG, Brooks, SC, Travers, A, et al. Emergency medical services management of ST-elevation myocardial infarction. Prehosp Emerg Care 2008;12(3):395-403.Google Scholar
51. Moser, DK, Kimble, LP, Alberts, MJ, et al. Reducing delay in seeking treatment by patients with acute coronary syndrome and stroke: a scientific statement from the American Heart Association Council on cardiovascular nursing and stroke council. Circulation 2006;114(2):168-182.Google Scholar
52. Kahn, JM, Branas, CC, Schwab, CW, et al. Regionalization of medical critical care: what can we learn from the trauma experience? Crit Care Med 2008;36(11):3085-3088.CrossRefGoogle ScholarPubMed
Figure 0

Table 1 Typical and potential regionalized systems of care.