This paper aims to contribute to the current debate about Posthumanism in archaeology, arguing for the potential that Posthumanism can have for the study of rock art. Through a case study in San Luis Potosí, Mexico, this work seeks to explore a posthuman approach to rock art as vibrant and relational assemblages, through affects as relational agencies and non-human personhood and ritual landscape as theoretical tools, articulated with aspects from indigenous ontologies explored from archaeological, ethnographic and documentary information. It is proposed that this approach can help interpret hunter-gatherer rock art created between 1000 and 1500 ce in the northern region of Mexico. Through this exercise it is considered that Mexican archaeology of rock art can embrace posthumanism for a more complex and comprehensive understanding of the painted memory of hunter-gatherers from this part of the world.