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Endocrine and physiological events from ovulation to establishment of pregnancy in cattle

Published online by Cambridge University Press:  27 February 2018

W.W. Thatcher ,
M. Binelli ,
D. Arnold ,
R. Mattos ,
L. Badinga ,
F. Moreira ,
C.R. Staples  and
A. Guzeloglu
W.W. Thatcher
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
M. Binelli
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
D. Arnold
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
R. Mattos
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
L. Badinga
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
F. Moreira
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
C.R. Staples
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
A. Guzeloglu
Affiliation:
University of Florida, Department of Dairy and Poultry Sciences, IFAS, PO Box 110920, Gainesville Florida, USA
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Abstract

A series of in vitro and in vivo experiments were conducted to characterise the dialogue between embryo and maternal units relative to the mechanisms controlling embryo survival in dairy cattle. Endometrial explants from pregnant cows had an attenuated PGF2α secretory response following treatment with melittin (stimulator of PLA2) and phorbol 12, 13 dibutyrate (PDBu). Thus previous exposure to the conceptus appears to regulate the endometrial synthetic pathway at a point coincident with or distal to PLA2 as well as inhibit PKC or PKC mediated events. Endometrial explants collected from cows receiving intrauterine infusions of rblFN-τ had a reduced secretory response following stimulation with PDBu indicating attenuation in PKC activity. Based upon tyrosine-phosphorylation of STAT-proteins and their translocation to the nucleus after treatment with rbIFN-τ, the JAK-STAT pathway is functional in immortalised bovine endometrial cells (BEND cells). Bend cells, exposed to rblFN-τ, reduced PDBu induction of PGF2α secretion and also decreased protein expression of Cox-2 and PLA. RblFN-τ clearly reduced PKC mediated events leading to an antiluteolytic response in endometrial cells. Feeding diets containing 2.6, 5.2 and 7.8% Menhaden fish meal to lactating dairy cows reduced uterine secretion of PGF2α following sequential injections of oestradiol and oxytocin. Thus antiluteolytic effects in early pregnancy may be amplified by feeding by-pass fats. Pregnancy rate to a timed insemination at first service post-partum is increased in association with injection of bST(500 mg; sc) given at insemination. Furthermore injection of bST at time of insemination in superovulated donor cows increased the number of blastocysts and reduced number of unfertilised embryos. Prospects of integrating novel strategies to improve embryo development and survival into reproductive management systems appear to be attainable in high producing dairy cows.

Type
Invited Papers
Information
BSAP Occasional Publication , Volume 26 , Issue 1: Fertility in the High Producing Dairy Cow , January 2001 , pp. 81 - 91
Copyright
Copyright © British Society of Animal Science 2001

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