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The prognostic value of the controlling nutritional status (CONUT) score on patients undergoing nephrectomy for upper tract urothelial carcinoma or renal cell carcinoma: a systematic review and meta-analysis

Published online by Cambridge University Press:  02 August 2021

Junhao Chen
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
Dehong Cao
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Zhufeng Peng
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Pan Song
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
Zhenghuan Liu
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
Luchen Yang
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
Linchun Wang
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
Jing Zhou
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
Qiang Wei*
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Qiang Dong*
Affiliation:
Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
*
# Corresponding authors: Department of Urology, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan, P.R. China. Post Code: 610041, Tel: +86 19181978796, Fax: +86 19181978796, E-mail: Qiang Wei, weiqiang933@126.com ; Qiang Dong, dqiang666@163.com
# Corresponding authors: Department of Urology, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan, P.R. China. Post Code: 610041, Tel: +86 19181978796, Fax: +86 19181978796, E-mail: Qiang Wei, weiqiang933@126.com ; Qiang Dong, dqiang666@163.com
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Abstract

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Background & aims:

In recent years, the controlling nutritional status (CONUT) score has increasingly became an effective indicator associated with tumor prognosis. This study was conducted to synthesise data on the prognostic value of CONUT score on patients with upper tract urothelial carcinoma (UTUC) or renal cell carcinoma (RCC) undergoing nephrectomy.

Methods:

We designed and performed a systematic analysis of studies that verified the correlation between preoperative CONUT score and prognosis for UTUC and RCC using PubMed, Web of Science and Embase. The conclusion was clarified by pooled hazard ratios (HR) and 95% confidence intervals (95% CI). Subgroup analysis were further conducted in accordance with different primary tumor.

Results:

Six studies involving 3529 patients were included in this evidence synthesis, which revealed that the CONUT score had a potential role to predict the survival of UTUC and RCC patients accepting surgery. Pooled analysis showed that the overall survival (OS, HR 2.32, p<0.0001), cancer-special survival (CSS, HR 2.68, p<0.0001) and disease-free survival (DFS, HR 1.62, p<0.00001) were inferior in the high CONUT score group when compared with low score group. Subgroup analysis revealed that this result was in line with UTUC (OS: HR 1.86, P=0.02; CSS: HR 2.24, P=0.01; DFS: HR 1.54, P<0.00001) and RCC (OS: HR 3.05, P<0.00001; CSS: HR 3.47, P<0.00001; DFS: HR 2.21, P=0.0005) patients respectively.

Conclusion:

The CONUT score is a valuable preoperative index to predict the survival of patients with UTUC or RCC undergoing nephrectomy.

Type
Full Papers
Copyright
© The Authors 2021

Footnotes

*

Equal study contribution

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The prognostic value of the controlling nutritional status (CONUT) score on patients undergoing nephrectomy for upper tract urothelial carcinoma or renal cell carcinoma: a systematic review and meta-analysis
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