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Olive oil and rapeseed oil differ in their effect on plasma low-density lipoprotein metabolism in the guinea-pig

Published online by Cambridge University Press:  09 March 2007

Maria Luz Fernandez ,
Anthony E. Soscia ,
Gwo-Shing Sun ,
Mark Tosca ,
Donald J. McNamara  and
Bruce E. McDonald
Maria Luz Fernandez
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Anthony E. Soscia
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Gwo-Shing Sun
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Mark Tosca
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Donald J. McNamara
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Bruce E. McDonald
Affiliation:
Department of Foods and Nutrition, University of Manitoba, Winnipeg, CanadaR3T 2N2
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Abstract

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The effects of olive oil and rapeseed oil, two different high-o1eic-acid oils, on plasma LDL and hepatic cholesterol metabolism were compared in guinea-pigs. Animals were fed on semipurified diet containing 150 g fat/kg as either olive oil (OL), rapeseed oil plus 100 g palm oil/kg (C-P) or olive oil plus 350 g safflowerseed oil/kg (OL-S). Olive oil was enriched with safllowerseed oil (OL-S diet) to increase linoleic acid and to decrease palmitic acid concentrations, in order to evaluate whether differences in plasma LDL concentrations were due to intrinsic effects of the specific oil (rapeseed or olive oil) or to differences in the content of specific fatty acids. No differences due to dietary fat source were found in plasma total and HDL-cholesterol levels or in LDL composition. Plasma LDL-cholesterol levels were lower on the C-P diet than the OL diet (P < 0·05) while plasma LDL-cholesterol levels in animals fed on the OL-S diet were not significantly different from either dietary group (P > 0·05). The number of hepatic apo B/E (LDL) receptors was on average 25% higher in animals fed on the C-P diet compared with those fed on diets containing olive oil. Likewise, cardiac muscle lipoprotein lipase (EC 3.1.1.34) activity was significantly higher in the C-P group than in the OL and OL-S dietary groups. Dietary fat source had no effect on hepatic cholesterol levels or 3-hydroxy-3-methylglutaryl (HMG) CoA reductase (EC 1.1.1.34) activity. The results indicate that olive oil and rapeseed oil, both rich sources of monoumaturated fatty acids, differ in their effect on LDL metabolism in the guinea-pig.

Keywords

Low-density lipoproteinRapeseed oilLipoprotein lipase
Type
General Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 6 , December 1996 , pp. 869 - 880
Copyright
Copyright © The Nutrition Society 1997

References

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