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No effect of copper supplementation on biochemical markers of bone metabolism in healthy adults

Published online by Cambridge University Press:  09 March 2007

Aimi Baker ,
Eithne Turley ,
Maxine P. Bonham ,
Jacqueline M. O'Connor ,
J. J. Strain ,
Albert Flynn  and
Kevin D. Cashman
Aimi Baker
Affiliation:
Department of Nutrition, University College, Cork, Republic of Ireland
Eithne Turley
Affiliation:
Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine BT52 1SA, UK
Maxine P. Bonham
Affiliation:
Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine BT52 1SA, UK
Jacqueline M. O'Connor
Affiliation:
Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine BT52 1SA, UK
J. J. Strain
Affiliation:
Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine BT52 1SA, UK
Albert Flynn
Affiliation:
Department of Nutrition, University College, Cork, Republic of Ireland
Kevin D. Cashman*
Affiliation:
Department of Nutrition, University College, Cork, Republic of Ireland
*
*Corresponding author: Dr Kevin D. Cashman, fax +353 21 270244, email k.cashman@ucc.ie
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Abstract

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The influence of Cu supplementation of the usual diet for 6 weeks on biochemical markers of bone turnover and on putative indices of Cu status was investigated in healthy adults (twelve male and twelve female) aged 22–46 years, who participated in a double-blind placebo-controlled repeated crossover study. The study consisted of three 6-week supplementation regimens of 3 mg CuSO4, 3 mg Cu–glycine chelate (CuGC), and 6 mg CuGC, each separated by placebo periods of equal length. During baseline and on the last day of each dietary period, fasting morning first-void urine and fasting blood serum, plasma and erythrocytes were collected. The habitual dietary Cu intakes in males and females were approximately 1·4 and 1·1 mg/d respectively. Females had significantly higher (50 %) plasma caeruloplasmin (Cp) protein concentrations than males at baseline. Cu supplementation had no effect on erythrocyte superoxide dismutase (SOD, EC 1.15.1.1) activity or plasma Cp protein (putative indices of Cu status) in the total group. Similarly, serum osteocalcin (a marker of bone formation), urinary creatinine (Cr) concentration, urinary pyridinoline : Cr or deoxypyridinoline : Cr excretion (markers of bone resorption) were unaffected in either the total group or in males and females separately, by any Cu supplementation regimen. It is concluded that Cu supplementation of the usual diet in healthy adult males and females had no effect on biochemical markers of bone formation or bone resorption over 6-week periods.

Keywords

CopperBoneBiochemical markers
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 4 , October 1999 , pp. 283 - 290
Copyright
Copyright © The Nutrition Society 1999

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