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Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea

Published online by Cambridge University Press:  09 December 2022

Tao Thi Tran ,
Madhawa Gunathilake ,
Jeonghee Lee ,
Il Ju Choi ,
Young-Il Kim  and
Jeongseon Kim Open the ORCID record for Jeongseon Kim [Opens in a new window]
Tao Thi Tran
Affiliation:
Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
Madhawa Gunathilake
Affiliation:
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
Jeonghee Lee
Affiliation:
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
Il Ju Choi
Affiliation:
Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea
Young-Il Kim
Affiliation:
Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea
Jeongseon Kim*
Affiliation:
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea
*
*Corresponding author: Jeongseon Kim, email jskim@ncc.re.kr
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Abstract

Mineral consumption has been suggested to have an impact on gastric cancer (GC) prevention. However, the protective effect of potassium against gastric carcinogenesis remains inconclusive. The causal link between inflammation and cancer is well established. Notably, potassium intake and potassium channels may play certain roles in regulating the production of TNF-α (TNF-α). We aimed to determine whether dietary potassium intake is related to the risk of GC. We further observed whether this association was modified by TNF-α rs1800629. We designed a case–control study comprising 377 GC cases and 756 controls. Information on dietary potassium intake was collected using a semiquantitative food frequency questionnaire. Genotyping was performed by the Affymetrix Axiom Exom 319 Array platform. Unconditional logistic regression models were used to assess associations. A significantly reduced GC risk was found for those who consumed higher dietary potassium levels (OR = 0·63, 95 % CI = 0·45, 0·89, P for trend = 0·009). In the dominant model, we observed a non-significant association between TNF-α rs1800629 and GC risk (OR = 1·01, 95 % CI = 0·68, 1·49). In females, those who were homozygous for the major allele (G) of rs1800629 with a higher intake of dietary potassium exhibited a decreased risk of GC (OR = 0·40, 95 % CI = 0·20, 0·78, P interaction = 0·041). This finding emphasises the beneficial effect of potassium intake on GC prevention. However, this association could be modified by TNF-α rs1800629 genotypes. A greater protective effect was exhibited for females with GG homozygotes and high potassium intake.

Keywords

PotassiumTNF-α rs1800629Gastric cancerCase–control study
Type
Research Article
Information
British Journal of Nutrition , Volume 130 , Issue 5 , 14 September 2023 , pp. 887 - 894
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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