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The effect of cortisone acetate on the course of development of experimental protein-energy malnutrition in rats

Published online by Cambridge University Press:  09 March 2007

P. G. Lunn ,
R. G. Whitehead ,
B. A. Baker  and
S. Austin
P. G. Lunn
Affiliation:
University of Cambridge and Medical Research Council, Dunn Nutrition Unit, Milton Road, Cambridge CB4 1XJ
R. G. Whitehead
Affiliation:
University of Cambridge and Medical Research Council, Dunn Nutrition Unit, Milton Road, Cambridge CB4 1XJ
B. A. Baker
Affiliation:
University of Cambridge and Medical Research Council, Dunn Nutrition Unit, Milton Road, Cambridge CB4 1XJ
S. Austin
Affiliation:
University of Cambridge and Medical Research Council, Dunn Nutrition Unit, Milton Road, Cambridge CB4 1XJ
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Abstract

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1. The role of corticosteroids in determining which clinical features of protein-energy malnutrition develop on a deficient diet has been studied by the administration of cortisone acetate to experimentally malnourished rats fed ad lib. on a mixture containing 31 g protein/kg.

2. Daily administration of 1.25 mg cortisone acetate did not affect dietary intake, which remained the same as in saline (9 g sodium chloride/l)-injected controls. Plasma albumin concentrations, however, increased from a low value of 25.7 g/1 to 47.2 g/l and this was accompanied by an increase both in liver weight and protein content. On the other hand, the protein content of muscle decreased.

3. These changes in the protein contents of liver and muscle were associated with alterations in the corresponding free amino acid pools. The free amino acid content of muscle generally decreased, but in liver many amino acids were increased.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 36 , Issue 3 , November 1976 , pp. 537 - 550
Copyright
Copyright © The Nutrition Society 1976

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